2000
DOI: 10.1016/s0190-9622(00)90136-1
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Tumors arising in nevus sebaceus: A study of 596 cases☆, ☆☆

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Cited by 385 publications
(380 citation statements)
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“…Majority occur in the genital skin and perineum (34.5%), followed by trunk (26.4%), head and neck (18.3%) and lower extremities (13.9%). 4 Apocrine carcinomas manifest as non-tender single or multiple, firm, rubbery or cystic masses with red to purple overlying skin. 5 Tumour cells are PAS (periodic acid-schiff stain) positive due to glycogen granules and diastase resistant Eccrine gland carcinomas possess no distinctive clinical features making diagnosis by gross appearance virtually impossible.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Majority occur in the genital skin and perineum (34.5%), followed by trunk (26.4%), head and neck (18.3%) and lower extremities (13.9%). 4 Apocrine carcinomas manifest as non-tender single or multiple, firm, rubbery or cystic masses with red to purple overlying skin. 5 Tumour cells are PAS (periodic acid-schiff stain) positive due to glycogen granules and diastase resistant Eccrine gland carcinomas possess no distinctive clinical features making diagnosis by gross appearance virtually impossible.…”
Section: Discussionmentioning
confidence: 99%
“…Some authors advocate prophylactic regional lymph node dissection, especially in patients with recurrent lesions after wide excision or with highly undifferentiated tumours. 4 Sweat gland carcinomas are radio resistant, and chemotherapy has been infrequently employed. Prognostic factors for sweat gland carcinoma are difficult to identify, again owing to the small number of reported cases.…”
Section: Discussionmentioning
confidence: 99%
“…However, this view was revised in several critical reviews stating that most of these basal cell carcinomas actually represented trichoblastomas. 6,7 Interestingly, the majority of basaloid tumors arising in nevus sebaceus are negative for PHLDA1, a follicular stem cell marker. PHLDA1 is generally positive in trichoepithelioma and trichoblastoma and negative in primary basal cell carcinoma.…”
Section: Discussionmentioning
confidence: 99%
“…Syringocystadenoma papilliferum (30 cases) and trichoblastoma (28 cases) were the most frequent benign tumors. (6) Other types of benign neoplasms are trichilemmoma, sebaceoma, seborrheic keratosis, syringoma, poroma, nodular hidradenoma, apocrine cystadenoma, and nonepithelial proliferations such as melanocytic nevi. (7) The true incidence of malignant tumors occurring in lesions of NS is difficult to determine.…”
Section: Discussionmentioning
confidence: 99%
“…(2) The proportion of malignant tumors occurring on NS is highly variable among the published series. Amongst malignant tumors, the most common is basal cell carcinoma.…”
Section: Introductionmentioning
confidence: 99%