Tumors of the anterior mediastinum

O’Gara, Roger W.; Horn, Robert C.; Enterline, Horatio T.

doi:10.1002/1097-0142(195805/06)11:3<562::aid-cncr2820110318>3.0.co;2-t

Cited by 60 publications

(16 citation statements)

References 17 publications

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“…This was in agreement with the studies done by Shrivastava et al, 11 Conkle and Adkins, 12 Rubush & colleagues, 13 Dubashi et al 14 and Azarow & colleagues 15 who found that thymomas were the most common mediastinal lesions. Studies done by Davis et al, 16 Cohen & colleagues, 17 Mullen & Richardson, 18 and Gara et al 19 found that thymomas were the most common anterior mediastinal lesions lending support to similar findings in the present study.…”

Section: Discussionsupporting

confidence: 91%

A clinicopathologic study of mediastinal lesions with special emphasis on thymomas

et al. 2015

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Section: Discussionsupporting

confidence: 91%

A clinicopathologic study of mediastinal lesions with special emphasis on thymomas

et al. 2015

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“…This has even been suggested as a sign in its differentiation from malignant lymphoma (O'Gara et al, 1958). Castleman (1955) stated that 'degeneration with haemorrhage within a thymoma can be so extensive that only a fibrous shell with small remnants of thymoma clinging to its surface is seen'.…”

Section: Discussionmentioning

confidence: 99%

“…Hubbell and Liebow (1952) have postulated that proliferation of lymphatics with infiltration of the gland stroma and subsequent distension occurs. However, O'Gara et al (1958) demonstrated that the cysts do not arise from blood vessels or lymphatics. Yamakawa, Tsuchiya, Naito, and Kawaguchi (1961) suggested that neoplastic change could occur in a simple thymic cyst.…”

Section: *mentioning

confidence: 99%

“…Pallisading of cells surrounding a cavity can occur (Seybold et al, 1950;O'Gara et al, 1958), and true epithelial-lined cysts have been reported, in which the lining may be squamoid, flat, or low columnar (Andritsakis and Sommers, 1959;Lattes, 1962;Legg and Brady, 1965). In true thymomas, cystic change is probably not influenced by the histological variant, since Bernatz et al (1961) recorded cysts in all four of their histological groups.…”

Section: *mentioning

confidence: 99%

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Cystic thymomas and thymic cysts: A Review

Dyer

1967

Thorax

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Six cases of large thymic cyst are described; five were cystic thymomas and one was nonneoplastic. Two of the thymomas were not only grossly degenerate but showed severe chronic inflammatory change, so that the diagnosis might be missed. (Davis, 1956). Although the clinical diagnosis of thymic cyst must ultimately await histological examination, it is hoped that a review of the subject will help the clinician in the differential diagnosis of mediastinal masses, especialiy as these cysts do not appear to be as rare as the literature suggests. MATERIALThe records of the Institute of Pathology and Department of Thoracic Surgery at the London Hospital were examined over the 16-year period from 1950 to 1965. Mediastinal tumours and cysts that were surgically treated during this period were reviewed. All cases of lymphoma and retrosternal goitre were excluded. The different lesions encountered are shown in Table I. The tumours classified as neurogenous included neurofibroma, ganglioneuroma, and neurilemmoma or their malignant counterparts. 'Present address:

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“…Of these 14, three were classified as atypical epithelial thymomas with granulomatous focuses, seven as granulomatous thymomas, and four as seminoma-like turnours. (OGara (29) found that among 51 tumours from the anterior mediastinum, in addition to 16 lymphoepitheliomas, there were three cases of thymic carcinoma, 10 malignant lymphomas, 10 teratomas (five benign cystic, five malignant), and eight unclassified tumours. Both these authors have noted the occurrence of malignant teratomas in the thymus and in the anterior mediastinum.…”

Section: Bernatz Et Al (4)mentioning

confidence: 99%

Tumours of the Thymus

Sundström

1975

Upsala Journal of Medical Sciences

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A series of 22 consecutive cases of thymic tumour was collected and the tumours were reclassified according to a modified classification scheme. Two-thirds of them were benign lympho-epitheliomas, though in one case pleural implants were noted. One-third of the tumours were clearly malignant (carcinomas, lymphomas and seminomas). In one of the seminomas and in a case of Hodgkin's disease of the thymus no signs of recurrence or metastases have been observed in 10 and 8 years respectively. The sex distribution was fairly equal except that all three seminomas were detected in young men. The malignant tumours usually gave rise to symptoms, while the benign ones did not. Four of the lympho-epitheliomas were associated with myasthenia gravis. No other associated syndrome was observed. The possibility that lympho-epitheliomas may be malignant is discussed.

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Tumors of the anterior mediastinum

Cited by 60 publications

References 17 publications

A clinicopathologic study of mediastinal lesions with special emphasis on thymomas

A clinicopathologic study of mediastinal lesions with special emphasis on thymomas

Cystic thymomas and thymic cysts: A Review

Tumours of the Thymus

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