2016
DOI: 10.1002/ijc.30067
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Tumour angiogenesis—Origin of blood vessels

Abstract: The conventional view of tumour vascularization is that tumours acquire their blood supply from neighbouring normal stroma. Additional methods of tumour vascularization such as intussusceptive angiogenesis, vasculogenic mimicry, vessel co-option and vasculogenesis have been demonstrated to occur. However, the origin of the endothelial cells and pericytes in the tumour vasculature is not fully understood. Their origin from malignant cells has been shown indirectly in lymphoma and neuroblastoma by immuno-FISH ex… Show more

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Cited by 126 publications
(64 citation statements)
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“…Moreover, the density of the inflammatory infiltrate in OTSCC is significantly correlated with cancer‐associated fibroblasts (CAFs) . Vascular endothelial growth factor and other growth factors such as epidermal growth factor are derived from stromal cells and endothelial cells, and promote tumour angiogenesis, which enhances tumour growth, survival, and metastasis . In OTSCC, CAFs identified by the use of α‐smooth muscle actin have been reported as key players in tumour progression, and they serve as an important prognostic marker in oral cancers, including all stages of OTSCC .…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, the density of the inflammatory infiltrate in OTSCC is significantly correlated with cancer‐associated fibroblasts (CAFs) . Vascular endothelial growth factor and other growth factors such as epidermal growth factor are derived from stromal cells and endothelial cells, and promote tumour angiogenesis, which enhances tumour growth, survival, and metastasis . In OTSCC, CAFs identified by the use of α‐smooth muscle actin have been reported as key players in tumour progression, and they serve as an important prognostic marker in oral cancers, including all stages of OTSCC .…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, the stromal cells can promote the infiltration and migration of tumor cells into the blood and lymph circulatory system; thus, tumor cells widely spread in the body. The stromal cells also promote metastasis by advancing angiogenesis and lymphangiogenesis, thus producing a significant negative effect on prognosis [42, 43]. …”
Section: Discussionmentioning
confidence: 99%
“…Increasing evidence indicates that enhanced expression of VEGF-A increases tumor relapse and poor prognosis. Therefore, VEGF-A represents a potential target for preventing angiogenesis and metastasis [31]. This study describes the clinical significance of WISP-3 and VEGF-A in patients with chondrosarcoma.…”
Section: Discussionmentioning
confidence: 99%