Tumour-Associated Tissue Eosinophilia in Head and Neck Squamous-Cell Carcinoma

Abstract

The possible role of tumour-associated tissue eosinophilia (TATE) as a prognostic factor in epithelial tumours has been investigated before. TATE is supposed to be associated with good prognosis. In this study concerning 63 patients with laryngeal and/or pharyngeal squamous-cell carcinoma, we tried to verify this hypothesis. Of the 25 patients with TATE, 17 (68%) had a good outcome opposed to 8 (32%) with a poor outcome. This numerically better chance for a good outcome in case of TATE was however not statistically significant. Uniformity of research material, staining and classification of TATE together with more representative and larger series of patients should ascertain the real value of TATE as a valid prognostic factor in head and neck squamous-cell carcinoma.

Association of mast cell, eosinophil leucocyte and microvessel densities in actinic cheilitis and lip squamous cell carcinoma

“…In the case of EL, chemotactic factors such as eotaxin, which exert a selective action on EL, have also been claimed to play a role in the mechanism of in situ EL infiltration and maintenance. A number of other factors appear to regulate the expression of vascular cell adhesion molecule‐1 (VCAM‐1), which is an important receptor in EL transmigration through the endothelium 39,50,58 . In this manner, the results reported herein could be associated with the migration processes and the accumulation sites of MC and EL during lip carcinogenesis because, once located in the tumour microenvironment, these cells could exert pro‐tumourigenic activities that would serve to stimulate the progression of lip tumour.…”

“…EL can stimulate tumour angiogenesis through synthesis and release of potent angiogenic factors 23,35–37 . Additionally, tumour‐associated tissue eosinophilia (TATE) 38 has been claimed to be involved in the biological behaviour and prognosis of various human malignancies 39–42 …”

“…23,[35][36][37] Additionally, tumour-associated tissue eosinophilia (TATE) 38 has been claimed to be involved in the biological behaviour and prognosis of various human malignancies. [39][40][41][42] It is presumed that the histological identification and quantification of specific inflammatory cells and microvessel densities (MVD) in tumours could provide an estimate of the interaction between these biomarkers and tumour angiogenesis, and of their consequences in oncogenesis and tumour prognosis. Therefore, the aim of the present study was to evaluate the densities of MC, EL and microvessels, and the relationships between these biomarkers, at different stages of lip carcinogenesis.…”

Tumor-Associated Tissue Eosinophilia as a Prognostic Factor in Squamous Cell Carcinoma of the Larynx

“…In a series of 422 patients with nasopharyngeal carcinoma, the TATE ratio was 21%. The overall ratio of TATE for the head and neck cancers was 40% in which laryngeal cancers have not been considered separately [13]. A concrete consensus on qualifying the TATE categories is not available yet.…”

“…Recently, eosinophilia has been investigated in head and neck carcinomas, especially the oral cavity carcinomas [7][8][9][10][11]. Although it has been shown that the relationship between eosinophil count and prognosis is statistically significant, it still remains controversial [12][13][14][15].…”