Tumour banks: well-guarded treasures in the interest of patients

Oosterhuis, J. Wolter; Coebergh, Jan Willem; Veen, Evert-Ben van

doi:10.1038/nrc973

Cited by 131 publications

(96 citation statements)

References 10 publications

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“…First, the tissue can be used for future diagnosis and treatment of the patient and, second, it is a valuable resource for medical research (Ashburn et al, 2000;van Diest, 2002;Oosterhuis et al, 2003;Weir and Olick, 2004). Consent for use of stored tissue for research purposes can be obtained in a variety of ways, and there is on-going discussion about which procedure complies best with patients' wishes while also being feasible in clinical practice (Maschke, 2005).…”

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confidence: 99%

A trial of consent procedures for future research with clinically derived biological samples

et al. 2009

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BACKGROUND: The aims of this study were to determine which consent procedure patients prefer for use of stored tissue for research purposes and what the effects of consent procedures on actual consenting behaviour are. METHODS: We offered 264 cancer patients three different consent procedures: 'one-time general consent' (asked written informed consent), 'opt-out plus' (had the opportunity to opt out by a form), or the standard hospital procedure (control group). The two intervention groups received a specific leaflet about research with residual tissue and verbal information. The control group only received a general hospital leaflet including opt-out information, which is the procedure currently in use. Subsequently, all patients received a questionnaire to examine their preferences for consent procedures. RESULTS: In all, 99% of patients consented to research with their residual tissue. In the 'one-time consent' group 85% sent back their consent form. Patients preferred 'opt-out plus' (43%) above 'one-time consent' (34%) or 'opt-out' (16%), whereas 8% indicated that they did not need to receive information about research with residual tissues or be given the opportunity to make a choice. CONCLUSIONS: The 'opt-out plus' procedure, which places fewer demands on administrative resources than 'one-time consent', can also address the information needs of patients.

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confidence: 99%

A trial of consent procedures for future research with clinically derived biological samples

et al. 2009

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“…51 Biobanking always starts with a conversation with a donor, which commences a relationship. This fundamental act is at the core of all ongoing interactions with biobanking practice.…”

Section: Fundamental 3: Biobanking Is Founded On Relationshipsmentioning

confidence: 99%

Getting the message about biobanking: returning to the basics

Catchpoole¹

2017

BSAM

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Much has been written about biobanks and biobanking. Since biobanking rose to prominence in the 1990s and became a scientific discipline in its own right, the collection and distribution of human tissue samples or "biospecimens" has been the subject of much critique, debate, and assessment. However, what is the message these discussions provide the wider research community? Are they reflective of progression of a new discipline? Do they represent clarity in the field or confusion? At one point we are told that biobanks are vital infrastructure, yet in the next breath we are told that biobanks are complex, full of risk, inefficient, and unsustainable. Biobanks struggle to receive sustainable funding with many restructuring or closing down, producing dilemmas about what to do with the legacy resources. This review critiques five key messages being relayed by the biobanking community, identifying the five messages that are actually being received by the research community. It also presents a "back to basics" view for biobanking that will return our attention back to five fundamental principles that should guide the ongoing discussion. This includes that biobanking is about the active provision of tissue for research that is vital for improved health outcomes. This activity is founded in human interrelationships, is already performed routinely within hospitals, and is driven by the opportunity to learn from the information contained within the biospecimens. The examples provided will be drawn from New South Wales, Australia, where building a state-wide biobanking infrastructure has been implemented, and which highlight areas where back to basics approach will be beneficial. A back to basics view of biobanking will highlight that the current positions proposed to deal with these issues are mere "straw men" solutions and that the need for a fundamental shift in our thinking is the real issue that needs to be addressed.

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“…For this reason, it is of great importance to build a tumor collection in good storage conditions (2).…”

Section: Commentsmentioning

confidence: 99%

“…According to the Council of Europe, (1997), in Commentary 137 to article 22, "a tumor bank is an organization responsible for collecting, cataloging, storing and disseminating samples of tissues, cells and fluids for the investigation of diagnostic molecular markers, definition of prognosis and identification of therapeutic targets (1), for facilitating the discovery of Basi�� an�� Translational Urology Basi�� an�� Translational Urology ��oi: 10.1590/S1677-55382010000300012 new therapies and new drugs, and for other applications yet to be discovered" (2).…”

Section: Introductionmentioning

confidence: 99%

Tumor banks: the cornerstone of basic research in urology

et al. 2010

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Purpose: Tumor banks have the primary responsibility for collecting, cataloging, storing and disseminating samples of tissues, cells and fluids, which are used by researchers to identify diagnostic molecular markers, prognostic indicators and therapeutic targets. The objective of this review was to describe a simple, reliable and reproducible protocol for obtaining and storing samples of urological tumors. Materials and Methods: Urogenital tumor tissues were collected by the surgeons from the Urology Division of University of Sao Paulo Medical School. The obtained surgical specimens were immediately placed in liquid nitrogen, dry ice or in a tube containing RNAlater ® , and then stored by cryopreservation (-80°C). A mirror fragment was fixed in 10% formalin processed routinely and embedded in Paraplast ® . Results:We developed a protocol for the collection, cataloging, storage, conservation and use of tumor samples. During a period of one year the Urological Tumor Bank of the Urology Division stored 274 samples of prostate, bladder, kidney, penis and testicle tumors of different histological types, 74 urine and 271 serum samples. Conclusions: Having biological materials characterized and available along with the clinical patient information provides an integrated portrait of the patients and their diseases facilitating advances in molecular biology. It also promotes the development of translational research improving methods of diagnosis and cancer treatment.

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Tumour banks: well-guarded treasures in the interest of patients

Cited by 131 publications

References 10 publications

A trial of consent procedures for future research with clinically derived biological samples

A trial of consent procedures for future research with clinically derived biological samples

Getting the message about biobanking: returning to the basics

Tumor banks: the cornerstone of basic research in urology

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