Tumour inflammatory infiltrate predicts survival following curative resection for node-negative colorectal cancer

Roxburgh, Campbell S.D.; Salmond, Jonathan; Horgan, Paul G.; Oien, Karin A.; McMillan, Donald C.

doi:10.1016/j.ejca.2009.04.011

Cited by 64 publications

(90 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent urological study is in agreement with our work having found no prognostic significance of Klintrup-Makinen scoring in renal cancer [22]. The lack of association may be tissue-specific as this scoring system has previously only been found to be of prognostic value in neoplastic tissue of non-prostate origin [17,23]. In addition, the clinical relevance of the local inflammatory cell infiltrate in BPH has been examined previously with varying results [24,25].…”

Section: Discussionsupporting

confidence: 79%

Body Mass Index Predicts Failure of Surgical Management in Benign Prostatic Hyperplasia

Willder

Walker²,

Halbert³

et al. 2012

Urol Int

Self Cite

View full text Add to dashboard Cite

Introduction: Inflammation is postulated to link obesity and benign prostatic hyperplasia (BPH). The role of inflammation and the prognostic significance of body mass index (BMI) was investigated in BPH patients. Subjects and Methods: Consecutive patients with histological BPH were identified from 1996 to 2005. Systemic inflammation was assessed by modified Glasgow Prognostic Score (mGPS) and local inflammation by Klintrup-Makinen criteria. Results: In 392 patients, BMI was associated with cardiovascular disease (p = 0.033), type 2 diabetes mellitus (p = 4.45 × 10^-8), aspirin usage (p = 0.018) and failure of surgical treatment (p = 0.001). mGPS and Klintrup-Makinen scores were not associated with clinical variables or outcome measures. On multivariate analysis BMI was an independent predictor of time to failure of surgical management of BPH, HR 1.56 (95% CI 1.11-2.19), p = 0.010. Conclusions: The mGPS and Klintrup-Makinen scores were not associated with BMI in BPH patients. High BMI is associated with failure of surgical management of BPH. Preoperative weight loss should be strongly encouraged in these patients.

show abstract

Section: Discussionsupporting

confidence: 79%

Body Mass Index Predicts Failure of Surgical Management in Benign Prostatic Hyperplasia

Willder

Walker²,

Halbert³

et al. 2012

Urol Int

Self Cite

View full text Add to dashboard Cite

show abstract

“…A recent urological study is in agreement with the remainder of our work having found no prognostic significance of Klintrup-Makinen scoring in renal cancer [11]. The lack of association may be related to tissue type as this scoring system has previously only been found to be of prognostic value in non-prostate cancerous tissue [12,16]. Other studies have examined the local inflammatory cell infiltrate in BPH, with varying results.…”

Section: Discussionsupporting

confidence: 76%

The Prognostic Use of Inflammation and Tissue Necrosis in Benign Prostatic Hyperplasia

et al. 2013

Self Cite

View full text Add to dashboard Cite

Introduction: Evidence for the role of inflammation in benign prostatic hyperplasia (BPH) is conflicting. Establishing the prognostic significance of local and systemic inflammation and tissue necrosis scoring systems in BPH may elucidate the potential of inflammatory pathways as a target of therapeutic intervention in these patients. Patients and Methods: Consecutive patients with histological BPH diagnosed between 1996 and 2005 were identified. Systemic inflammation was assessed by the modified Glasgow prognostic score (mGPS), local inflammation by the Klintrup-Makinen criteria and tissue necrosis was evaluated by an extent-based classification. Results: In 392 BPH patients, there was a trend for increased local inflammation and tissue necrosis to be associated with shorter time to failure of pre-operative medical treatment of BPH (p = 0.096 and 0.088, respectively). High modified Glasgow prognostic score was associated with older age (p = 0.002) and higher levels of deprivation (measured by the Scottish Index of Multiple Deprivation) (p = 0.021). Conclusions: The prognostic use of established scoring systems of systemic and local inflammation and tissue necrosis in BPH requires further investigation. It remains unclear as to whether targeting inflammation in BPH has therapeutic potential.

show abstract

“…6 The latter scheme has been demonstrated to be associated with survival of colorectal cancer patients in several studies. 6,11,22,23 Herein, Roxburgh et al 22 have compared both scoring systems and found an independent association with patients' survival in node-negative colorectal cancers only for the Klintrup-Mäkinen scheme. Furthermore, the inter-observer concordance was superior for the Klintrup-Mäkinen scheme.…”

Section: Discussionmentioning

confidence: 99%

Peritumoral eosinophils predict recurrence in colorectal cancer

et al. 2015

View full text Add to dashboard Cite

In colorectal cancer, the presence and extent of eosinophil granulocyte infiltration may render important prognostic information. However, it remains unclear whether an increasing number of eosinophils might simply be linked to the overall inflammatory cell reaction or represent a self-contained, antitumoral mechanism that needs to be documented and promoted therapeutically. Peri-and intratumoral eosinophil counts were retrospectively assessed in 381 primary colorectal cancers from randomly selected patients. Tumors were diagnosed in American Joint Committee on Cancer (AJCC)/Union Internationale Contre le Cancer (UICC) stage I in 21%, stage II in 32%, stage III in 33%, and stage IV in 14%. Presence and extent of eosinophils was related to various histopathological parameters as well as patients' outcome. Overall, peri-and intratumoral eosinophils were observed in 86 and 75% cancer specimens. The peritumoral eosinophil count correlated strongly with the intratumoral eosinophil count (R ¼ 0.69; Po0.001) and with the intensity of the overall inflammatory cell reaction (R ¼ 0.318; Po0.001). Both increasing peri-and intratumoral eosinophil counts were significantly associated with lower T and N classification, better tumor differentiation, absence of vascular invasion, as well as improved progression-free and cancer-specific survival. However, only peritumoral eosinophils, but not intratumoral, were an independent prognosticator of favorable progression-free (hazard ratio 0.75; 95% confidence interval 0.58-0.98; P ¼ 0.04) and cancer-specific survival (hazard ratio 0.7; 95% confidence interval 0.52-0.93; P ¼ 0.01)-independent of the intensity of overall inflammatory cell reaction. This was also found for patients with AJCC/ UICC stage II disease, wherein the presence of peritumoral eosinophils was significantly associated with favorable outcome. In conclusion, the number of peritumoral eosinophils had a significant favorable impact on prognosis of colorectal cancer patients independent of the overall tumor-associated inflammatory response. Evaluation of peritumoral eosinophils represents a promising readily assessable tool and should therefore routinely be commented on in the pathology report.

show abstract

Tumour inflammatory infiltrate predicts survival following curative resection for node-negative colorectal cancer

Cited by 64 publications

References 21 publications

Body Mass Index Predicts Failure of Surgical Management in Benign Prostatic Hyperplasia

Body Mass Index Predicts Failure of Surgical Management in Benign Prostatic Hyperplasia

The Prognostic Use of Inflammation and Tissue Necrosis in Benign Prostatic Hyperplasia

Peritumoral eosinophils predict recurrence in colorectal cancer

Contact Info

Product

Resources

About