Tumour Necrosis Factor Enhances induction by beta-Interferon of a Ubiquitin Cross-reactive Protein

Restricted replication of respiratory syncytial virus in human alveolar macrophages

“…TNF~ inhibits RSV infection of blood monocytes (Midulla et al, 1989) as well as other cell types (Wong & Goeddel, 1986;Mestan et al, 1986;Ahrens et al, 1990) and, as shown here, restricted RSV replication in alveolar macrophages although not as potently as in vitro differentiation. RSV rapidly induces TNFa expression by alveolar macrophages resulting in production of this cytokine up to levels comparable to those employed here (Panuska et al, 1990b;Becker et al, 1991).…”

Isolation of a Novel Ubiquitin-like Protein from Pleurotus ostreatus Mushroom with Anti-Human Immunodeficiency Virus, Translation-Inhibitory, and Ribonuclease Activities

“…This anti-HIV activity of Pleurotus ubiquitin-like protein is in line with its structural resemblance to ubiquitin, and ribosome inactivating protein and its RNase activity. In this connection, it is worth noting that interferon induces de novo synthesis of a 15 kDa protein structurally and immunologically related to ubiquitin, concurrently with the establishment of the antiviral state (34,35). From the mushroom Rozites caperata a (37).…”

Novel NEMO/IκB Kinase and NF-κB Target Genes at the Pre-B to Immature B Cell Transition

“…MyD118 is a mediator of growth suppression and apoptosis in differentiating cells (46). UCRP/ISG15, a novel 15-kDa ubiquitin homologue, is activated as part of the cellular response to viral infection, type I interferons, and TNF-␣ (47,48).…”

“…UCRP/ISG15 is a ubiquitin-like polypeptide that is transcriptionally induced by IFN␤-dependent antiviral responses and TNF-␣ (47,48). We found that NF-B activation was essential for UCRP/ISG15 expression by 70Z/3 pre-B cells (Figs.…”