Tumour necrosis factor may contribute to the anaemia of malaria by causing dyserythropoiesis and erythrophagocytosis

Clark, Ian A.; Chaudhri, Geeta

doi:10.1111/j.1365-2141.1988.tb02440.x

Cited by 224 publications

(152 citation statements)

References 21 publications

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“…8 Proinflammatory cytokines such as TNF, IL-1, and IL-6 are released by monocytes and suppress erythropoietin synthesis in adults with symptomatic malaria. [9][10] Similar observations have been made in children with persistent, asymptomatic Plasmodium falciparum malaria. 11 Reduced erythropoietin production or action might possibly explain reports 12 of reduced numbers of red cell precursors in acute malaria.…”

Section: Introductionsupporting

confidence: 64%

Malarial anemia leads to adequately increased erythropoiesis in asymptomatic Kenyan children

Verhoef

West

Kraaijenhagen

et al. 2002

Blood

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Malarial anemia is associated with a shift in iron distribution from functional to storage compartments. This suggests a relative deficit in erythropoietin production or action similar to that observed in other infections. Our study in Kenyan children with asymptomatic malaria aimed at investigating whether malaria causes increased erythropoiesis, and whether the erythropoietic response appeared appropriate for the degree of resulting anemia. Longitudinal and baseline data were used from a trial with a 2 ؋ 2 factorial design, in which 328 anemic Kenyan children were randomly assigned to receive either iron or placebo, and sulfadoxinepyrimethamine or placebo. Erythropoiesis was evaluated by serum concentrations of erythropoietin and soluble transferrin receptor. Prospectively collected data showed that malarial infection resulted in decreased hemoglobin concentrations, and increased serum concentrations of erythropoietin and transferrin receptor. Conversely, disappearance of malarial antigenemia resulted in increased hemoglobin concentrations, and decreased concentrations of these serum indicators. Additionally, our baseline data showed that current or recent malarial infection is associated with increased serum concentrations of erythropoietin and transferrin receptor, and that these were as high as or perhaps even higher than values of children without malarial infection and without inflammation. Our findings indicate that in asymptomatic malaria, the erythropoietic response is adequate for the degree of anemia, and that inflammation probably plays no or only a minor role in the pathogenesis of the resulting anemia. Further research is needed to demonstrate the role of deficient erythropoietin production or action in the pathogenesis of the anemia of symptomatic malaria. (Blood. 2002;100: 3489-3494)

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Section: Introductionsupporting

confidence: 64%

Malarial anemia leads to adequately increased erythropoiesis in asymptomatic Kenyan children

Verhoef

West

Kraaijenhagen

et al. 2002

Blood

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“…Other contributory factors may include decreased red cell deformability, splenic phagocytosis and/or pooling, so they have an increased rate of clearance from the circulation. [10][11][12] Brooks et al 13 had reported the correlation of serum potassium, and the hemolysis of red blood cells in patients infected with malaria which agrees with the present study. According to the present study, a statistically lower plasma sodium level mean of 131.56±6.63 against the mean control level of 134.14±5.955 was observed.…”

Section: Discussionsupporting

confidence: 83%

The profiles of packed cells volume, plasma electrolytes and glucose levels in malarial infected patients

Udoh

Olaniran

Udo

et al. 2017

Microbiol Res (Pavia)

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Fifty patients (18 males, 32 females) with malaria infection and 50 apparently healthy control subjects (22 males, 28 females) were recruited for the study. Hematocrit level (PCV) was determined using Heco C haematology analyzer. Plasma electrolytes (Na + , K + , HCO 3 -, Cl -), and glucose were respectively analyzed by SM23A Spectrophotometer, using TECO DIAGNOSTICS and RANDOX enzymatic glucose methods respectively. The results showed a significant reduction in the mean values of PCV (30.04±5.31%), Na + (131.56±6.63 mmol/L), and glucose (85.92±13.85 mg/dL) in the malaria-infected subjects compared with the mean values of PCV (38.74±3.12%), Na + (134.14±5.95 mmol/L), and glucose (92.40±13.99 mg/dL) (P<0.05) obtained from the control subjects. We observed higher significant mean values of K + (3.93±0.79 mmol/L) and HCO 3 -(23.56±2.55 mmol/L) in the malariainfected subjects compared with the control mean values of K + (3.62±0.51mmol/L) and HCO 3 -(23.48±2.02 mmol/L) (P<0.05). The mean values for chloride observed in the malaria-infected subjects, Cl -(99.52±7.44) was higher than the observed mean in the control subjects, Cl -(99.50±6.33), but was not statistically significant P>0.05. The mean (±standard deviation) of PCV, Na + , K + , HCO 3 -, Cl -and glucose in malariainfected patients of different age groups were compared with the age-matched controls, and there were significant differences only in the age groups involving PCV and potassium in the 1-20 and >40 age brackets. This study has shown the importance of electrolyte management in patients with severe malaria to prevent attendant physiological failure during complications.

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“…The different values may be associated with environmental factors, socioeconomic status, or malaria immunity, among other factors (12)(13)(14). The study has further revealed that there were no statistically significant differences in granulocyte and lymphocyte counts between malaria-infected and noninfected children, and these findings are in agreement with many earlier reports (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25) but disagree with the findings of George and Ewelike-Ezeani (17). In some cases of acute malaria, however, lymphopenia has been reported, but this has been associated with redistribution of lymphocytes with sequestration in the spleen (26,27).…”

Section: Discussionsupporting

confidence: 82%

“…In this study, significantly lower values of haematocrit and haemoglobin concentration have been observed in malaria-infected children compared to the controls, and these findings are in agreement with previous reports (6,11,17). Anaemia in malaria, however, is associated with a combination of haemolysis of parasitised red blood cells, accelerated removal of both parasitised and innocently unparasitised red blood cells, depressed and ineffective erythropoiesis due to tumour necrosis factor alpha, anaemia of chronic disease, and splenic phagocytosis or pooling (18)(19)(20)(21).…”

Section: Discussionmentioning

confidence: 99%

Haematological changes in malaria-infected children in North-West Nigeria

Momodu¹,

Shehu²,

Ihesiulor³

et al. 2013

Turk J Med Sci

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Neodymium-titania/silica films were prepared by the sol-gel method with the addition of various amounts of hydroxy propyl cellulose (HPC) and 5.09 × 10 −5 g g −1 solution of carboxy methyl cellulose (CMC) in saturated conditions. The porous Nd-TiO 2 /SiO 2 was obtained after heat treatment for 2 h at 500 • C, with the surface area up to 276 m 2 g −1 , which was measured using the Brunauer, Emmett, and Teller (BET) method. Scanning electron microscopy (SEM) showed that the particle size of Nd-TiO 2 /SiO 2 decreased and the microstructure of the film became loose in suitable conditions with the addition of CMC to HPC. Subsequently, the photocatalytic activity of Nd-TiO 2 /SiO 2 film under visible light irradiation was achieved to an optimum when the concentrations became 3.825 × 10 −3 and 5.09 × 10 −5 g g −1 sol. for HPC and CMC, respectively.

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Tumour necrosis factor may contribute to the anaemia of malaria by causing dyserythropoiesis and erythrophagocytosis

Cited by 224 publications

References 21 publications

Malarial anemia leads to adequately increased erythropoiesis in asymptomatic Kenyan children

Malarial anemia leads to adequately increased erythropoiesis in asymptomatic Kenyan children

The profiles of packed cells volume, plasma electrolytes and glucose levels in malarial infected patients

Haematological changes in malaria-infected children in North-West Nigeria

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