Tumour necrosis factor ‐ physiology and pathology

May, S. A.; Knottenbelt, Derek C.

doi:10.1111/j.2042-3292.1992.tb01571.x

Cited by 3 publications

(2 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are few (if any) biochemical or haematological tests that will establish a general diagnosis of neoplasia, let alone a specific type; such a test would be a valuable clinical aid but would, in any case, itself be unlikely to confirm the type and location of the tumour. Recent advances in our understanding of neoplastic disease suggest that, at least in some cases, estimation of TNF-α, IL-1 and interferon-γ (May and Knottenbelt 1992;Cotchin et al 1998) may provide nonspecific information. Specific tumour markers are being identified in some human neoplastic diseases, such as prostate-specific antigen (PSA) in prostatic carcinoma and CA-15-3 in breast cancer, and this is clearly very helpful in these conditions.…”

Section: Fig 5: A) Disseminated Haemangiosarcoma Secondary Tumours Inmentioning

confidence: 99%

Unilateral hindlimb swelling may be a sign of serious disseminated neoplasia in horses

Knottenbelt

Clegg

2004

Equine Veterinary Education

Self Cite

View full text Add to dashboard Cite

Section: Fig 5: A) Disseminated Haemangiosarcoma Secondary Tumours Inmentioning

confidence: 99%

Unilateral hindlimb swelling may be a sign of serious disseminated neoplasia in horses

Knottenbelt

Clegg

2004

Equine Veterinary Education

Self Cite

View full text Add to dashboard Cite

“…Tumour necrosis factor is best known for its role in endotoxaemia and systemic infections. Endotoxins stimulate cells of monocyte/macrophage lineage to produce various inflammatory mediators and some of these act on other cells to produce the full spectrum of pathology associated with endotoxaemia and septicaemia (May and Knottenbelt 1992;Moms 1992). Tumour necrosis factor, with interleukin 1, interleukin 6 and gamma interferon, is one of the endogenous pyrogens, producing pyrexia associated with infection by resetting the body's thermal set-point.…”

Section: Equine Veterinary Journalmentioning

confidence: 99%

Tumour necrosis factor, equine arthritis and clinical research

May

1995

Equine Veterinary Journal

Self Cite

View full text Add to dashboard Cite

Effects of lidocaine on lipopolysaccharide-induced synovitis in horses

Campebell¹,

Peiró

Valadão

et al. 2004

Arq. Bras. Med. Vet. Zootec.

View full text Add to dashboard Cite

Lidocaine (100mg 2%) injected into the carpal joint was used to evaluate the inflammatory response induced by injection (1.5ng) of intra-articular E. coli lipopolysaccharide (LPS) endotoxin. Seventeen male Mangalarga horses aged two to three years were divided into three groups and in all animals was injected 0.9% saline (SAL) in the left carpus (LC), and in the right carpus (RC) one of the following combinations were injected: group A (n=6) LPS plus SAL; group B (n=6) LPS plus lidocaine; group C (n=5) lidocaine plus SAL. Synovial fluid and blood samples were collected immediately before the injection of LPS (T0), and at 1.5 (T1), 3 (T2), 6 (T3), 12 (T4) and 36 hours (T5) after the injection. Clinical and physical variables and cellular and biochemical characteristics of the synovial fluid were evaluated at the same time. The local and systemic inflammatory response was evaluated by measurement of mean serum and synovial fluid TNF-α concentration. A rise in TNF-α concentration in LPS injected joints at 3h in group A and from 1.5h to 3h in group B was observed. It is concluded that LPS triggered an inflammatory process and that lidocaine did not inhibit or attenuate the LPS-induced synovitis nor the synthesis and release of TNF-α.Keywords: horse, synovitis, lipopolysacharide, TNF-α, lidocaine RESUMO Injetou-se lidocaína (100mg 2%) na articulação do carpo para avaliar a resposta inflamatória induzida pela injeção (1,5ng) intra-articular de lipopolissacarídeo (LPS) de E. coli. Utilizaram-se 17 cavalos Mangalarga não castrados, entre dois e três anos, divididos em três grupos. No carpo esquerdo (CE) administrou-se solução fisiológica a 0,9% (SAL) e no carpo direito (CD) uma das seguintes combinações: grupo A (n=6) LPS mais SAL, grupo B (n=6) LPS mais lidocaína e grupo C (n=5) lidocaína mais SAL. Amostras do líquido sinovial e de sangue foram colhidas imediatamente antes da injeção de LPS (T0) e às 1,30 (T1), 3 (T2), 6 (T3), 12 (T4) e 36 horas (T5) após a injeção. Variáveis clínicas e físicas, e características bioquímicas e celulares do líquido sinovial foram avaliadas nos mesmos tempos. A resposta inflamatória local e sistêmica foi mensurada pela concentração do TNF-α no

show abstract

Tumour necrosis factor ‐ physiology and pathology

Cited by 3 publications

References 27 publications

Unilateral hindlimb swelling may be a sign of serious disseminated neoplasia in horses

Unilateral hindlimb swelling may be a sign of serious disseminated neoplasia in horses

Tumour necrosis factor, equine arthritis and clinical research

Effects of lidocaine on lipopolysaccharide-induced synovitis in horses

Contact Info

Product

Resources

About