Tumours of the urinary bladder in cattle and water buffalo in the Black Sea region of Turkey

Özkul, İbrahim Ayhan; Aydin, Y.

doi:10.1016/s0007-1935(96)80041-8

Cited by 20 publications

(25 citation statements)

References 2 publications

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“…6 Endothelial tumors were classified as hemangiomas, hemangioendotheliomas, and hemangiosarcomas. Although the designation hemangioendothelioma is infrequently used in veterinary pathology, 10,16,26,32,33,52 this category was adopted in the present study to deal with the heterogeneity within this group and assist the correlation between the expression levels of selected proteins and tumor grade. This category includes lesions with microscopic features intermediate between hemangiomas and hemangiosarcomas in terms of cellularity, mitotic activity, presence of well-formed vascular channels, and degree of invasion.…”

Section: Histologic Typing and Immunohistochemical Studiesmentioning

confidence: 99%

Immunohistochemical Evaluation of Vascular Urinary Bladder Tumors from Cows with Enzootic Hematuria

Carvalho¹,

Naydan

Nunes³

et al. 2009

Veterinary Pathology

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Abstract. Fifty-six endothelial-derived urinary bladder tumor samples collected from 26 animals with bovine enzootic hematuria were selected for immunohistochemical studies. Expression of factor VIII-related antigen (FVIIIra), CD31, muscle-specific actin, uroplakin III (UPIII), and the cell cyclerelated proteins cyclin D1 and p53 was evaluated in hemangiomas, ''hemangioendotheliomas'' (a vascular tumor that histologically is intermediate in appearance between a hemangioma and a conventional hemangiosarcoma), and hemangiosarcomas. Although CD31 expression was seen in all endothelial tumors tested, FVIIIra was not expressed in poorly differentiated endothelial tumor cells from solid areas or in 7 muscle-invasive hemangiosarcomas. Cyclin D1 overexpression was seen in 53% of hemangiomas, 82% of hemangioendotheliomas, and 95% of hemangiosarcomas. P53 immunoreactivity was only seen in muscle-invasive hemangiosarcomas. The UPIII staining pattern, normally very intense on the apical aspect and cytoplasm of superficial urothelial cells, was altered in the urothelium in an estimated 25% of hemangiomas, most hemangioendotheliomas, and most hemangiosarcomas. In conclusion, CD31 is a better marker than FVIIIra in the characterization of bovine endothelial tumors. The cell cycle regulatory pathways involving cyclin D1 and p53 seem to be impaired in endothelial urinary bladder tumors, p53 immunoreactivity positively correlating with enhanced invasion.

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Section: Histologic Typing and Immunohistochemical Studiesmentioning

confidence: 99%

Immunohistochemical Evaluation of Vascular Urinary Bladder Tumors from Cows with Enzootic Hematuria

Carvalho¹,

Naydan

Nunes³

et al. 2009

Veterinary Pathology

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“…Enzootic haematuria cases have been described in cattle that graze on fern-covered areas of Turkey [5,6] . However, there are limited studies regarding water buffalo with enzootic haematuria [5,[23][24][25][26] .…”

Section: Discussionmentioning

confidence: 99%

“…The bracken ferns contain toxic chemicals. The syndrome is primarily encountered in Brazil, China, Italy, Japan, Portugal, Turkey, and New Zealand [1][2][3][4][5][6][7][8][9] . Haematuria is a clinical finding of chronic enzootic haematuria appearing sporadically and attracting attention permanently.…”

Section: Introductionmentioning

confidence: 99%

“…Anaemia and weight loss are also amongst the common clinical findings [2,8] . The long process of digestion triggers the syndrome in cattle and buffalo over the age of two [5,10,11] . It has been determined that different types of ferns, e.g.…”

Section: Introductionmentioning

confidence: 99%

“…Cystitis, epithelial hyperplasia, and hydropic degeneration are mentioned as non-neoplastic findings of the syndrome. Neoplastic findings of mesenchymal origin (hemangioma, hemangiosarcoma, fibroma, and myxoma) and epithelial origin (papilloma and transitional cell carcinoma) are reported [2,5,6] .…”

Section: Introductionmentioning

confidence: 99%

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Türkiye’de Marmara, Orta ve Batı Karadeniz Bölgelerinde Bulunan Mandaların İdrar Keselerinde Rastlanılan Tümörlerin Patomorfolojik ve İmmunohistokimyasal Yönden İncelenmesi

Tenekeci¹,

Öztekin²,

Bozkurt³

et al. 2017

Kafkas Univ Vet Fak Derg

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In this study, non-neoplastic and neoplastic lesions in the urinary bladders of water buffalo were determined in the Marmara, the central and western part of the Black Sea region of Turkey. In this context, water buffalo with lesions in the urinary bladder were obtained from the private and public slaughterhouses of several provinces. The lesions were evaluated pathologically and immunohistochemically. In addition, species of bracken ferns were identified in these provinces. Histopathologically, 39 of the collected tissue samples were diagnosed as neoplasia. These neoplasms were classified and graded according to The World Health Organization Classification of Tumours published in 2004. In this context, papilloma (16 cases), papillary urothelial neoplasm of low malignant potential (PUNLMP) (7 cases), low-grade papillary carcinoma (13 cases), high-grade papillar carcinoma (2 cases), and low-grade papillary carcinoma with hemangiosarcoma (1 case) were detected in samples diagnosed as neoplasia. In the collected bracken ferns, Athyrium filix-foemina (L.) Roth; Dryopteris dilatata (Hoffm.) Gary; Dryopteris filixmas (L.) Schott; Polystichum aculeatum (L.) Roth; Polystichum setiferum (Forsk.) Woynar; Polystichum woronowii Fomin, Polypodium vulgare L. and Pteridium aquilinum (L.) Kuhn spp. were identified. As a result, it has been understood that the consumption of identified bracken ferns leads more frequently to epithelial neoplasms. Keywords

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Tumors of the Urinary System

Meuten¹

2002

Tumors in Domestic Animals

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Tumours of the urinary bladder in cattle and water buffalo in the Black Sea region of Turkey

Cited by 20 publications

References 2 publications

Immunohistochemical Evaluation of Vascular Urinary Bladder Tumors from Cows with Enzootic Hematuria

Immunohistochemical Evaluation of Vascular Urinary Bladder Tumors from Cows with Enzootic Hematuria

Türkiye’de Marmara, Orta ve Batı Karadeniz Bölgelerinde Bulunan Mandaların İdrar Keselerinde Rastlanılan Tümörlerin Patomorfolojik ve İmmunohistokimyasal Yönden İncelenmesi

Tumors of the Urinary System

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