Tunable Antimicrobial Polypropylene Surfaces: Simultaneous Attachment of Penicillin (<i>Gram</i>+) and Gentamicin (<i>Gram</i>−)

Aumsuwan, Nattharika; McConnell, Matthew S.; Urban, Marek W.

doi:10.1021/bm8013473

Cited by 49 publications

(28 citation statements)

References 27 publications

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“…As shown in the field of bioconjugation, such hydrophilic spacers lead to high bioavailability of the active compound, combined with low unspecific protein adhesion . There are various examples of antibiotics that have thus been surface‐immobilized using PEG spacers . Other polymers and surface architectures were also used to present covalently attached antimicrobial components (e.g., antimicrobial peptides or quaternary ammoinium compounds) …”

Section: Materials With Combined Antimicrobial Activity and Protein‐rmentioning

confidence: 99%

“…[74] There are various examples of antibiotics that have thus been surface-immobilized using PEG spacers. [100,101] Other polymers and surface architectures were also used to present covalently attached antimicrobial components (e.g., antimicrobial peptides or quaternary ammoinium compounds). [102][103][104][105][106] In yet another approach to obtain bifunctional materials, the antimicrobial polymer is the active component, not just the matrix, and is combined with a protein-repellent polymer.…”

Section: Non-leaching Materialsmentioning

confidence: 99%

See 1 more Smart Citation

Polymer‐Based Surfaces Designed to Reduce Biofilm Formation: From Antimicrobial Polymers to Strategies for Long‐Term Applications

Riga¹,

Vöhringer²,

Widyaya³

et al. 2017

Macromol. Rapid Commun.

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Contact-active antimicrobial polymer surfaces bear cationic charges and kill or deactivate bacteria by interaction with the negatively charged parts of their cell envelope (lipopolysaccharides, peptidoglycan, and membrane lipids). The exact mechanism of this interaction is still under debate. While cationic antimicrobial polymer surfaces can be very useful for short-term applications, they lose their activity once they are contaminated by a sufficiently thick layer of adhering biomolecules or bacterial cell debris. This layer shields incoming bacteria from the antimicrobially active cationic surface moieties. Besides discussing antimicrobial surfaces, this feature article focuses on recent strategies that were developed to overcome the contamination problem. This includes bifunctional materials with simultaneously presented antimicrobial and protein-repellent moieties; polymer surfaces that can be switched from an antimicrobial, cell-attractive to a cell-repellent state; polymer surfaces that can be regenerated by enzyme action; degradable antimicrobial polymers; and antimicrobial polymer surfaces with removable top layers.

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Section: Materials With Combined Antimicrobial Activity and Protein‐rmentioning

confidence: 99%

Section: Non-leaching Materialsmentioning

confidence: 99%

Polymer‐Based Surfaces Designed to Reduce Biofilm Formation: From Antimicrobial Polymers to Strategies for Long‐Term Applications

Riga¹,

Vöhringer²,

Widyaya³

et al. 2017

Macromol. Rapid Commun.

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show abstract

“…5 These strategies involve the design of coatings or bulk materials that utilize various bactericides or drugs such as silver ions, 6 halamine, 7 cationic polymers, [8][9][10][11] antimicrobial peptides, 12 antibiotics. 13 However, poor hemocompatibility or drug resistance is of great concern. 14 When contacting with bloodstream, a cascade of events is initiated, e.g., protein adsorption, platelet adhesion and activation, and finally result in a thrombus on a biomedical device surface.…”

mentioning

confidence: 99%

Facile Fabrication of Lubricant-Infused Wrinkling Surface for Preventing Thrombus Formation and Infection

Yuan

Luan

Yan

et al. 2015

ACS Appl. Mater. Interfaces

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Despite the advanced modern biotechniques, thrombosis and bacterial infection of biomedical devices remain common complications that are associated with morbidity and mortality. Most antifouling surfaces are in solid form and cannot simultaneously fulfill the requirements for antithrombosis and antibacterial efficacy. In this work, we present a facile strategy to fabricate a slippery surface. This surface is created by combining photografting polymerization with osmotically driven wrinkling that can generate a coarse morphology, and followed by infusing with fluorocarbon liquid. The lubricant-infused wrinkling slippery surface can greatly prevent protein attachment, reduce platelet adhesion, and suppress thrombus formation in vitro. Furthermore, E. coli and S. aureus attachment on the slippery surfaces is reduced by ∼98.8% and ∼96.9% after 24 h incubation, relative to poly(styrene-b-isobutylene-b-styrene) (SIBS) references. This slippery surface is biocompatible and has no toxicity to L929 cells. This surface-coating strategy that effectively reduces thrombosis and the incidence of infection will greatly decrease healthcare costs.

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“…Microwave plasma reaction in the presence of maleic anhydride results in the formation of acid groups on the surface of PP. This modification of the plasma surface helps the attachment of antibiotics such as penicillin V (PEN) and gentamicin (GEN) to the modified PP surface through the reaction of the acid group on the PP surface and polyethylene glycol (PEG), diglycidyl PEG respectively (Aumsuwan et al 2009).…”

Section: Polymeric Biomaterialsmentioning

confidence: 99%

Gas plasmas and plasma modified materials in medicine

Cheruthazhekatt¹,

et al. 2010

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The applications of gas plasma and plasma modified materials in the emerging fields of medicine such as dentistry, drug delivery, and tissue engineering are reviewed. Plasma sterilization of both living and nonliving objects is safe, fast and efficient; for example plasma sterilization of medical equipment quickly removes microorganisms with no damage to the tiny delicate parts of the equipment and in dentistry it offers a non-toxic, painless bacterial inactivation of tissues from a dental cavity. Devices that generate plasma inside the root canal of a tooth give better killing efficiency against bacteria without causing any harm to the surrounding tissues. Plasma modified materials fulfill the requirements for bioactivity in medicine; for example, the inclusion of antimicrobial agents (metal nano particles, antimicrobial peptides, enzymes, etc.) in plasma modified materials (polymeric, metallic, etc.) alters them to produce superior antibacterial biomedical devices with a longer active life. Thin polymer films or coating on surfaces with different plasma processes improves the adherence, controlled loading and release of drug molecules. Surface functionalization by plasma treatment stimulates cell adhesion, cell growth and the spread of tissue development. Plasma applications are already contributing significantly to the changing face of medicine and future trends are discussed in this paper.

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Tunable Antimicrobial Polypropylene Surfaces: Simultaneous Attachment of Penicillin (Gram+) and Gentamicin (Gram−)

Cited by 49 publications

References 27 publications

Polymer‐Based Surfaces Designed to Reduce Biofilm Formation: From Antimicrobial Polymers to Strategies for Long‐Term Applications

Polymer‐Based Surfaces Designed to Reduce Biofilm Formation: From Antimicrobial Polymers to Strategies for Long‐Term Applications

Facile Fabrication of Lubricant-Infused Wrinkling Surface for Preventing Thrombus Formation and Infection

Gas plasmas and plasma modified materials in medicine

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