Tunable synthesis and multifunctionalities of Fe3O4–ZnO hybrid core-shell nanocrystals

Liu, Hongling; Wu, Junhua; Min, Ji Hyun; Zhang, Xiaoyan; Kim, Young Keun

doi:10.1016/j.materresbull.2012.11.051

Cited by 48 publications

(37 citation statements)

References 53 publications

(35 reference statements)

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“…The CSNPs were prepared according to a modified nanoemulsion method (Liu et al ., ) and consisted of a superparamagnetic Fe 3 O 4 core covered with a photonic ZnO shell. As described in our previous study (Cho et al ., ), the final CSNPs were uniformly spherical and monodispersed in shape with a diameter of approximately 15.7 nm.…”

Section: Resultsmentioning

confidence: 97%

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The toxicity and distribution of iron oxide–zinc oxide core‐shell nanoparticles in C57BL/6 mice after repeated subcutaneous administration

Yun

Yoon

Kang

et al. 2015

J of Applied Toxicology

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Therapeutic cancer vaccines promote immune responses by delivering tumour-specific antigens. Recently, we developed iron oxide (Fe3 O4 )-zinc oxide (ZnO) core-shell nanoparticles (CSNPs) as carriers for antigen delivery into dendritic cells (DCs), and the CSNPs were injected subcutaneously into C57BL/6 mice to examine the systemic toxicity, tissue distribution and excretion of the CSNPs. The doses injected were 0, 4, 20 and 200 mg kg(-1) weekly for 4 weeks. No significant changes were observed after the CSNPs administration with respect to mortality, clinical observations, body weight, food intake, water consumption, urinalysis, haematology, serum biochemistry,and organ weights. A dose-dependent increase in granulomatous inflammation was observed at the injection site of the CSNP-treated animals, but no other histopathological lesions in other organs could be attributed to the CSNPs. The Zn concentration, which is an indicator for CSNPs, was not significantly higher in the sampled tissues, urine, or faeces after the CSNP injection. In contrast, the Zn concentration at the subcutaneous skin of the site injected with the CSNPs increased in a dose-dependent manner, along with a macroscopic deposition of the CSNPs. The CSNP residue at the injection site resulted in a foreign body response with the appearance of macrophage infiltration, but otherwise did not show any systemic distribution or toxicity at up to 200 mg kg(-1) during this study. In conclusion, CSNPs could be used as good antigen carriers for DC-based immunotherapy, although further study is needed to completely clear the residue of the CSNPs at the injection site.

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Section: Resultsmentioning

confidence: 97%

“…The CSNPs were prepared at Korea University (Seoul, Korea) using a modified nanoemulsion method (Liu et al ., ). The size and morphology of the nanoparticles were measured via transmission electron microscopy (TEM, JEOL 2010 F; JEOL Ltd., Tokyo, Japan), as previously described (Cho et al ., ).…”

Section: Methodsmentioning

confidence: 99%

The toxicity and distribution of iron oxide–zinc oxide core‐shell nanoparticles in C57BL/6 mice after repeated subcutaneous administration

Yun

Yoon

Kang

et al. 2015

J of Applied Toxicology

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“…The diffraction by deeply buried Fe 3 O 4 core is so weak to be detected [25,26]. Further, it has been shown that the intensity of XRD peaks of Fe 3 O 4 core decreases with increase of the thickness of ZnO shell and the X-ray reflections of Fe 3 O 4 core is completely suppressed by thick ZnO shell [28]. Raman spectroscopy affords information on the local crystalline structure.…”

Section: Fe 3 O 4 -Implanted Ag 2 S-capped Znomentioning

confidence: 99%

Synthesis of superparamagnetic biocidal superior solar photocatalytic Fe3O4-implanted Ag2S-capped ZnO micro-clubbells

2019

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Semiconductor-photocatalytic mineralization of organics is an emerging technology. However, recovery of the photocatalytic particles post pollutant-mineralization is a stumbling block for adoption of this technique. Implantation of magnetic core in the particulate photocatalyst ensures magnetic recovery. The magnetic core, deeply buried in the photocatalytic semiconductor lattice, is secluded from the photocatalyst/effluent interface and has insignificant influence on the photocatalytic processes. As the magnetic core is concealed its photocorrosion is overcome. With this, we report synthesis of Fe 3 O 4-implanted Ag 2 S-capped ZnO microstructure by a two-step hydrothermal process. Scanning electron micrograph shows the synthesized particles as micro-clubbell-shaped. The energy dispersive X-ray spectrum confirms the presence of the constituent elements and the elemental mapping images display the even distribution of the constituent elements in the micro-clubbells. The X-ray diffractogram and the Raman spectrum show ZnO in zincite structure and Ag 2 S in acanthite phase. The synthesized microstructure and precursor Fe 3 O 4 nanocrystals are superparamagnetic and their magnetic properties are comparable. The charge-transfer resistance of the microstructure is more than 20-fold that of Fe 3 O 4 nanocrystals (New J Chem 40:1845-1852, 2016). The micro-clubbells absorb in the entire visible region and displays strong absorption in the UV-A region. The microcomposite exhibits green and strong blue-green emissions and the lifetime of photogenerated charge carriers is 10 ps. The synthesized microsized clubbell is mesoporous and its specific surface area is comparable to those of nanostructured composites. The synthesized microcomposite (1) displays superior photocatalytic activity under natural sunlight and (2) is reusable and magnetically recoverable. In addition, the title microstructure exhibits bactericidal activity, even without direct illumination.

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“…Saha et al reported Fe doped CdTeS quantum dots capped with N -acetyl-cysteine (NAC) ligands. 57 Due to the concern about potential leakage of highly toxic cadmium ions, researchers have attempted to synthesis non-cadmium based QD (e.g., ZnO, [58][59][60] ZnS, 61 62 InP, 63 64 CuInS 2 65 ), and many of those QDs are also used to produce multimodality probes. Lin et al reported a CuInS 2 /Zn 1−x Mn x S Core/Shell QDs.…”

Section: Quantum Dotsmentioning

confidence: 99%

Nanoparticulate Contrast Agents for Multimodality Molecular Imaging

Xia¹,

Murukeshan²,

Su³

et al. 2016

j biomed nanotechnol

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Molecular imaging is rapidly developing as a powerful tool in research and medical diagnostic. By integrating complementary signal reporters into a single nanoparticulate contrast agent, multimodal molecular imaging can be performed as scalable images with high sensitivity, resolution and specificity. In this review, multifunctional nanoparticles (MFNPs) are classified into four types: conjugation, encapsulation, core/shell, and co-doping. Further, new constructs of MFNPs were reported recently which have used nanoparticulate contrast agent such as quantum dots (QDs), iron oxide nanoparticles (IONPs), Upconversion nanoparticles (UCNPs), carbon based nanoparticles, gold nanoparticles (Au-NPs), Metal-Organic Frameworks (MOFs), dendrimers and porphyrins based nanoparticles. Different surface modification strategies were also developed as well as ligands are attached to those NPs to render the biocompatibility and enable specific targeting. These new development in MFNPs are expected to introduce a paradigm shift in multi-modal molecular imaging and thereby opening up an era of personalized medicine and new diagnostic medical imaging tools.

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Tunable synthesis and multifunctionalities of Fe3O4–ZnO hybrid core-shell nanocrystals

Cited by 48 publications

References 53 publications

The toxicity and distribution of iron oxide–zinc oxide core‐shell nanoparticles in C57BL/6 mice after repeated subcutaneous administration

The toxicity and distribution of iron oxide–zinc oxide core‐shell nanoparticles in C57BL/6 mice after repeated subcutaneous administration

Synthesis of superparamagnetic biocidal superior solar photocatalytic Fe3O4-implanted Ag2S-capped ZnO micro-clubbells

Nanoparticulate Contrast Agents for Multimodality Molecular Imaging

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