Tuning Characteristics of Ocular and Cervical Vestibular Evoked Myogenic Potentials in Intact and Dehiscent Ears

Taylor, Rachael L.; Bradshaw, Andrew P.; Halmagyi, G. Michael; Welgampola, Miriam S.

doi:10.1159/000336959

Cited by 64 publications

(66 citation statements)

References 72 publications

(43 reference statements)

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“…Similar findings are also reported for oVEMP responses in healthy subjects [Chihara et al, 2009;Murnane et al, 2011]. However, it is reported that 500 Hz is not always the best stimulation frequency; for some subjects, 750 or 1,000 Hz might be optimal [Piker et al, 2013;Taylor et al, 2012]. The effect of stimulus frequency on the amplitude of cVEMP responses varies with age, with young adults giving peak amplitudes at 750 Hz, while older adults required 1,000-Hz stimulation [Piker et al, 2013].…”

Section: Discussionsupporting

confidence: 80%

Diagnostic Value of Frequency-Associated Vestibular-Evoked Myogenic Potential Responses in Ménière's Disease

Şalvız

Yüce²,

Karataş³

et al. 2015

Audiol Neurotol

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Thirty subjects with unilateral Ménière's disease (MD) and 18 age-matched controls underwent cervical (cVEMP) and ocular vestibular-evoked myogenic potential (oVEMP) testing using bilateral air-conducted stimulation (ACS) with stimulus frequencies of 500 and 1,000 Hz. The aim of this study is to determine the diagnostic value of frequency-associated responses in MD using oVEMP and cVEMP following 500- and 1,000-Hz ACS. In healthy controls and unaffected ears, responses to 500 Hz were found better than 1,000-Hz ACS in both oVEMP and cVEMP, while ears with MD responded to 1,000-Hz ACS better than to 500-Hz ACS in oVEMP. In cVEMP tests, affected ears responded to 500-Hz and 1,000-Hz ACS equally. Amplitude ratios of 1,000/500 Hz in both oVEMP and cVEMP were successful in differing affected ears from unaffected ears and healthy controls. This study showed frequency alteration of oVEMP and cVEMP can be used as a diagnostic test battery in MD.

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Section: Discussionsupporting

confidence: 80%

Diagnostic Value of Frequency-Associated Vestibular-Evoked Myogenic Potential Responses in Ménière's Disease

Şalvız

Yüce²,

Karataş³

et al. 2015

Audiol Neurotol

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show abstract

“…Previous studies indicated that threshold was more valuable than peak-to-peak amplitude in distinguishing healthy from pathological ears in both SCD and Mé-nière's disease [Brantberg et al, 1999;Rauch et al, 2004;Taylor et al, 2012]. Thresholds, however, overlap between the SCD and healthy populations, and threshold measurement can be time consuming.…”

Section: Introductionmentioning

confidence: 99%

Toward Optimizing cVEMP: 2,000-Hz Tone Bursts Improve the Detection of Superior Canal Dehiscence

et al. 2018

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Background: The cervical vestibular evoked myogenic potential (cVEMP) test measures saccular and inferior vestibular nerve function. The cVEMP can be elicited with different frequency stimuli and interpreted using a variety of metrics. Patients with superior semicircular canal dehiscence (SCD) syndrome generally have lower cVEMP thresholds and larger amplitudes, although there is overlap with healthy subjects. The aim of this study was to evaluate which metric and frequency best differentiate healthy ears from SCD ears using cVEMP. Methods: Twenty-one patients with SCD and 23 age-matched controls were prospectively included and underwent cVEMP testing at 500, 750, 1,000 and 2,000 Hz. Sound level functions were obtained at all frequencies to acquire threshold and to calculate normalized peak-to-peak amplitude (VEMPn) and VEMP inhibition depth (VEMPid). Third window indicator (TWI) metrics were calculated by subtracting the 250-Hz air-bone gap from the ipsilateral cVEMP threshold at each frequency. Ears of SCD patients were divided into three groups based on CT imaging: dehiscent, thin or unaffected. The ears of healthy age-matched control subjects constituted a fourth group. Results: Comparing metrics at all frequencies revealed that 2,000-Hz stimuli were most effective in differentiating SCD from normal ears. ROC analysis indicated that for both 2,000-Hz cVEMP threshold and for 2,000-Hz TWI, 100% specificity could be achieved with a sensitivity of 92.0%. With 2,000-Hz VEMPn and VEMPid at the highest sound level, 100% specificity could be achieved with a sensitivity of 96.0%. Conclusion: The best diagnostic accuracy of cVEMP in SCD patients can be achieved with 2,000-Hz tone burst stimuli, regardless of which metric is used.

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“…34 Of patients and controls aged .40 years, 93.8% had corrected amplitude values greater than the mean 12 SD of the control group. However, neither the sensitivity nor the specificity could be determined in this subset.…”

Section: 32mentioning

confidence: 87%

“…There were 9 Class III studies. 24,25,[28][29][30][31][32][33][34] A meta-analysis was considered but not performed given the heterogeneity of the studies.…”

mentioning

confidence: 99%

Practice guideline: Cervical and ocular vestibular evoked myogenic potential testing

et al. 2017

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Objective: To systematically review the evidence and make recommendations with regard to diagnostic utility of cervical and ocular vestibular evoked myogenic potentials (cVEMP and oVEMP, respectively). Four questions were asked: Does cVEMP accurately identify superior canal dehiscence syndrome (SCDS)? Does oVEMP accurately identify SCDS? For suspected vestibular symptoms, does cVEMP/oVEMP accurately identify vestibular dysfunction related to the saccule/utricle? For vestibular symptoms, does cVEMP/oVEMP accurately and substantively aid diagnosis of any specific vestibular disorder besides SCDS?Methods: The guideline panel identified and classified relevant published studies

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Tuning Characteristics of Ocular and Cervical Vestibular Evoked Myogenic Potentials in Intact and Dehiscent Ears

Cited by 64 publications

References 72 publications

Diagnostic Value of Frequency-Associated Vestibular-Evoked Myogenic Potential Responses in Ménière's Disease

Diagnostic Value of Frequency-Associated Vestibular-Evoked Myogenic Potential Responses in Ménière's Disease

Toward Optimizing cVEMP: 2,000-Hz Tone Bursts Improve the Detection of Superior Canal Dehiscence

Practice guideline: Cervical and ocular vestibular evoked myogenic potential testing

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