Abstract:Hybrid hydrogels containing alginate (Alg) and poly(N-isopropylacrylamide) (PNIPAAm) chains as natural and synthetic
components,
respectively, were crosslinked using double and triple pairs of the
crosslinkers Ce3+/Ce4+, laponite (LP) RD, and N,N’-methylenebisacrylamide (BIS).
(Alg/PNIPAAm)-Ce3+ and (Alg/PNIPAAm-PNIPAAm)-Ce3+ double- and triple-network structures were prepared using multivalent
cerium ions (Ce3+), multifunctional laponite layers (L),
and/or neutral tetrafunctonal BIS molecules (B). Compressiv… Show more
“…The element cerium commonly exists in the form of trivalent or tetravalent ions and functions in the form of cerium dioxide. 187 They have exceptional free radical scavenging capabilities and can endure oxidative stress, thereby exerting the positive effects of alleviating inflammatory responses, reducing cellular damage, and modulating cellular differentiation. 188–190 Incorporating cerium in biomaterials enhances MSC activity, stimulates osteogenic differentiation, and promotes bone extracellular matrix formation.…”
Section: Regulating Bone Metabolism With Metal Ionsmentioning
In recent years, bone regeneration has emerged as a remarkable field that offers promising guidance for treating bone-related diseases, such as bone defects, bone infections, and osteosarcoma. Among various bone...
“…The element cerium commonly exists in the form of trivalent or tetravalent ions and functions in the form of cerium dioxide. 187 They have exceptional free radical scavenging capabilities and can endure oxidative stress, thereby exerting the positive effects of alleviating inflammatory responses, reducing cellular damage, and modulating cellular differentiation. 188–190 Incorporating cerium in biomaterials enhances MSC activity, stimulates osteogenic differentiation, and promotes bone extracellular matrix formation.…”
Section: Regulating Bone Metabolism With Metal Ionsmentioning
In recent years, bone regeneration has emerged as a remarkable field that offers promising guidance for treating bone-related diseases, such as bone defects, bone infections, and osteosarcoma. Among various bone...
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