We study the rise of exceptional points of degeneracy (EPD) in various distinct circuit configurations such as gyrator-based coupled resonators, coupled resonators with PT-symmetry, and in a single resonator with a time-varying component. In particular, we analyze their high sensitivity to changes in resistance, capacitance, and inductance and show the high sensitivity of the resonance frequency to perturbations. We also investigate stability and instability conditions for these configurations; for example, the effect of losses in the gyrator-based circuit leads to instability, and it may break the symmetry in the PT-symmetry-based circuit, also resulting in instabilities. Instability in the PT-symmetry circuit is also generated by breaking PT-symmetry when one element (e.g., a capacitor) is perturbed due to sensing. We have turned this instability “inconvenience” to an advantage, and we investigate the effect of nonlinear gain in the PT-symmetry coupled-resonator circuit and how this leads to an oscillator with oscillation frequency very sensitive to perturbation. The circuits studied in this paper have the potential to lead the way for a more efficient generation of high-sensitivity sensors that can detect very small changes in chemical, biological, or physical quantities.