This article features the recent developments in fluorographene (FG) and its other functional forms such as fluorographene oxide-their synthesis, fluorination, defluorination, and applications. FG is identified as an important functional derivative of graphene, and FG's multifunctionalities make it as an ideal candidate for diverse fields, say from photovoltaic to bio-medical diagnosis, imaging, sensing, and therapy. Here the possibilities of FG as a biomedical sensing platform is discussed in detail and the potentials of FG based electrochemical and conductometric sensing platforms are unraveled. The importance of fluorine control as well as the other key factors need to be considered while choosing FG based bio-sensing platforms are also discussed.