Tuning the conductivity and inner structure of electrospun fibers to promote cardiomyocyte elongation and synchronous beating

Liu, Yaowen; Lu, Jianhua; Xu, Guisen; Wei, Jiaojun; Zhang, Zhibin; Li, Xiaohong

doi:10.1016/j.msec.2016.07.069

Cited by 74 publications

(56 citation statements)

References 43 publications

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“…The ECHs coaxially electrospun with a 5% CNT concentration (C5) achieved an average beating rate of 70-80 times/min, which was similar to that rate of CMs seeded on other non-conductive hydrogels (e). [171], Copyright 2016. Reproduced with permission from Elsevier Inc. through electrospinning poly(ethylene glycol)-poly(D,L-Lactide) (PELA) copolymers with CNTs onto a spinning mandrel [171].…”

Section: Sourcesmentioning

confidence: 99%

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Rational design of microfabricated electroconductive hydrogels for biomedical applications

Walker

Portillo-Lara

Mogadam

et al. 2019

Progress in Polymer Science

167

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Electroconductive hydrogels (ECHs) are highly hydrated three-dimensional (3D) networks generated through the incorporation of conductive polymers, nanoparticles, and other conductive materials into polymeric hydrogels. ECHs combine several advantageous properties of inherently conductive materials with the highly tunable physical and biochemical properties of hydrogels. Recently, the development of biocompatible ECHs has been investigated for various biomedical applications, such as tissue engineering, drug delivery, biosensors, flexible electronics, and other implantable medical devices. Several methods for the synthesis of ECHs have been reported, which include the incorporation of electrically conductive materials such as gold and silver nanoparticles, graphene, and carbon nanotubes, as well as various conductive polymers (CPs), such as polyaniline, polypyrrole, and poly(3,4-ethylenedioxyythiophene) into hydrogel networks. These electroconductive composite hydrogels can be used as scaffolds with high swellability, tunable mechanical properties, and the capability to support cell growth both in vitro and in vivo. Furthermore, recent advancements in microfabrication techniques such as 3D bioprinting, micropatterning, and electrospinning have led to the development of ECHs with biomimetic microarchitectures that reproduce the characteristics of the native extracellular matrix (ECM). The combination of sophisticated synthesis chemistries and modern microfabrication techniques have led to engineer smart ECHs with advanced architectures, geometries, and functionalities that are being increasingly used in drug delivery systems, biosensors, tissue engineering, and soft electronics. In this review, we will summarize different strategies to synthesize conductive biomaterials. We will also discuss the advanced microfabrication techniques used to fabricate ECHs with complex 3D architectures, as well as various biomedical applications of microfabricated ECHs.

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Section: Sourcesmentioning

confidence: 99%

“…[171], Copyright 2016. Reproduced with permission from Elsevier Inc. through electrospinning poly(ethylene glycol)-poly(D,L-Lactide) (PELA) copolymers with CNTs onto a spinning mandrel [171]. Their approach investigated the efficacy of both blend electrospinning and coaxial electrospinning techniques.…”

Section: Sourcesmentioning

confidence: 99%

Rational design of microfabricated electroconductive hydrogels for biomedical applications

Walker

Portillo-Lara

Mogadam

et al. 2019

Progress in Polymer Science

167

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“…One of the most important aspects in the design of TE scaffolds is the accurate recapitulation of the different stimuli that modulate cell fate. CMs are electroactive cells that rely on electrical stimuli for maintaining tissue homeostasis and function [62]. Therefore, electroconductive scaffolds hold great potential for cardiac TE since they can promote the propagation of electrical impulses and enhance electromechanical coupling of CMs in vitro [63].…”

Section: In Vitro Contractile Activity and Phenotype Of Cms Cultured mentioning

confidence: 99%

Engineering a naturally-derived adhesive and conductive cardiopatch

et al. 2019

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Myocardial infarction (MI) leads to a multi-phase reparative process at the site of damaged heart that ultimately results in the formation of non-conductive fibrous scar tissue. Despite the widespread use of electroconductive biomaterials to increase the physiological relevance of bioengineered cardiac tissues in vitro, there are still several limitations associated with engineering biocompatible scaffolds with appropriate mechanical properties and electroconductivity for cardiac tissue regeneration. Here, we introduce highly adhesive fibrous scaffolds engineered by electrospinning of gelatin methacryloyl (GelMA) followed by the conjugation of a choline-based bio-ionic liquid (Bio-IL) to develop conductive and adhesive cardiopatches. These GelMA/Bio-IL adhesive patches were optimized to exhibit mechanical and conductive properties similar to the native myocardium. Furthermore, the engineered patches strongly adhered to murine myocardium due to the formation of ionic bonding between the Bio-IL and native tissue, eliminating the need for suturing. Co-cultures of primary cardiomyocytes and cardiac fibroblasts grown on GelMA/Bio-IL patches exhibited comparatively better contractile profiles compared to pristine GelMA controls, as demonstrated by over-expression of the gap junction protein connexin 43. These cardiopatches could be used to provide mechanical support and restore electromechanical coupling at the site of MI to minimize cardiac remodeling and preserve normal cardiac function.

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“…Conductive materials, such as carbon nanotubes (CNTs) and polyaniline (PANI), were incorporated as the “therapeutic agents” in these cases to form the conductive network in the scaffolds. [160d,164] Liu et al164 loaded up to 6% of CNTs into highly aligned PEG‐PLLA copolymer (PELA) fibers through both blend and co‐axial electrospinning. In vitro cardiomyocytes culture indicated that scaffolds containing higher ratios of CNTs could favorably maintain the cell viabilities, induce the cell elongation, accelerate the production of sarcomeric α‐actinin and troponin I, and enhance the synchronous beating of cardiomyocytes.…”

Section: Applications In Biomedical Fieldsmentioning

confidence: 99%

Electrospun Fibrous Architectures for Drug Delivery, Tissue Engineering and Cancer Therapy

Ding

Zhang

et al. 2018

Adv Funct Materials

217

138

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The versatile electrospinning technique is recognized as an efficient strategy to deliver active pharmaceutical ingredients and has gained tremendous progress in drug delivery, tissue engineering, cancer therapy, and disease diagnosis. Numerous drug delivery systems fabricated through electrospinning regarding the carrier compositions, drug incorporation techniques, release kinetics, and the subsequent therapeutic efficacy are presented herein. Targeting for distinct applications, the composition of drug carriers vary from natural/synthetic polymers/blends, inorganic materials, and even hybrids. Various drug incorporation approaches through electrospinning are thoroughly discussed with respect to the principles, benefits, and limitations. To meet the various requirements in actual sophisticated in vivo environments and to overcome the limitations of a single carrier system, feasible combinations of multiple drug-inclusion processes via electrospinning could be employed to achieve programmed, multi-staged, or stimuli-triggered release of multiple drugs. The therapeutic efficacy of the designed electrospun drugeluting systems is further verified in multiple biomedical applications and is comprehensively overviewed, demonstrating promising potential to address a variety of clinical challenges.

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Tuning the conductivity and inner structure of electrospun fibers to promote cardiomyocyte elongation and synchronous beating

Cited by 74 publications

References 43 publications

Rational design of microfabricated electroconductive hydrogels for biomedical applications

Rational design of microfabricated electroconductive hydrogels for biomedical applications

Engineering a naturally-derived adhesive and conductive cardiopatch

Electrospun Fibrous Architectures for Drug Delivery, Tissue Engineering and Cancer Therapy

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