Tuning the formation and stability of microcapsules by environmental conditions and chitosan structure

Ren, Ying; Xie, Hehu; Liu, Xiaocen; Yang, Fan; Wu, Yu; Ma, Xiaojun

doi:10.1016/j.ijbiomac.2016.06.034

Cited by 21 publications

(5 citation statements)

References 51 publications

(71 reference statements)

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“…Moreover, the binding interaction is influenced by other factors such as polymer chain conformation and intrinsic chain flexibility . The increase of pH might make CS molecules transform from a fully extended to a more compact conformation (due to less electrostatic repulsion), beneficial to their binding with CMC molecules, in agreement with the result found in the binding interaction between chitosan and alginate . To shed light on the complex network formation in our current model system, Figure c shows a schematic comparing the intermolecular interaction mainly involving ionic crosslinking at different charge stoichiometries.…”

Section: Resultssupporting

confidence: 75%

“…24 The increase of pH might make CS molecules transform from a fully extended to a more compact conformation (due to less electrostatic repulsion), beneficial to their binding with CMC molecules, in agreement with the result found in the binding interaction between chitosan and alginate. 25 To shed light on the complex network formation in our current model system, Figure 1c shows a schematic comparing the intermolecular interaction mainly involving ionic crosslinking at different charge stoichiometries. Nonstoichiometric complexation with excessive cationic charges (pH 3.6−4.5) produces a small binding enthalpy and leads to a relaxed, low level of ionic crosslinking network (lower G′ and G″).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Electrostatically Complexed Natural Polysaccharides as Aqueous Barrier Coatings for Sustainable and Recyclable Fiber-Based Packaging

Chi

Lin

et al. 2023

ACS Appl. Mater. Interfaces

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Driven by the ever-growing awareness of sustainability and circular economy, renewable, biodegradable, and recyclable fiberbased packaging materials are emerging as alternatives to fossil-derived, nonbiodegradable single-use plastics for the packaging industry. However, without functional barrier coatings, the water/moisture vulnerability and high permeability of fiber-based packaging significantly restrain its broader application as primary packaging for food, beverages, and drugs. Herein, we develop waterborne complex dispersion barrier coatings consisting of natural, biodegradable polysaccharides (i.e., chitosan and carboxymethyl cellulose) through a scalable, one-pot mechanochemical pathway. By tailoring the electrostatic complexation, the key element to form a highly crosslinked and interpenetrated polymer network structure, we formulate complex dispersion barrier coatings with excellent film-forming property and adaptable solid-viscosity profiles suitable for paperboard and molded pulp substrates. Our complex dispersions enable the formation of a uniform, defect-free, and integrated coating layer, leading to a remarkable oil and grease barrier and efficient water/moisture sensitivity reduction while still exhibiting excellent recyclability profile of the resulting fiber-based substrates. This natural, biorenewable, and repulpable barrier coating is a promising candidate to serve as a sustainable option for fiber-based packaging intended for the food and food service packaging industry.

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Section: Resultssupporting

confidence: 75%

Section: ■ Results and Discussionmentioning

confidence: 99%

Electrostatically Complexed Natural Polysaccharides as Aqueous Barrier Coatings for Sustainable and Recyclable Fiber-Based Packaging

Chi

Lin

et al. 2023

ACS Appl. Mater. Interfaces

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“…Unassembled polymer was removed by washing three times with 0.1 M NaCl. Fluorescein-labeled CHI/Hep microcapsules were synthesized by adding one layer of rhodamine B–CHI during the assembly process. − In order to construct Janus capsule motors, a droplet of the CHI/Hep microparticle solution was dropped on a hydrophilic silica slide to form a monolayer of microparticles. After evaporation in air, a turbo sputter coater (Quorum Technologies, K575X) was used to coat one side of the polymeric particles with a thin gold layer (65 mV, 30 s).…”

Section: Methodsmentioning

confidence: 99%

Erythrocyte Membrane Modified Janus Polymeric Motors for Thrombus Therapy

et al. 2018

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We report the construction of erythrocyte membrane-cloaked Janus polymeric motors (EM-JPMs) which are propelled by near-infrared (NIR) laser irradiation and are successfully applied in thrombus ablation. Chitosan (a natural polysaccharide with positive charge, CHI) and heparin (glycosaminoglycan with negative charge, Hep) were selected as wall materials to construct biodegradable and biocompatible capsules through the layer-by-layer self-assembly technique. By partially coating the capsule with a gold (Au) layer through sputter coating, a NIR-responsive Janus structure was obtained. Due to the asymmetric distribution of Au, a local thermal gradient was generated upon NIR irradiation, resulting in the movement of the JPMs through the self-thermophoresis effect. The reversible “on/off” motion of the JPMs and their motile behavior were easily tuned by the incident NIR laser intensity. After biointerfacing the Janus capsules with an erythrocyte membrane, the EM-JPMs displayed red blood cell related properties, which enabled them to move efficiently in relevant biological environments (cell culture, serum, and blood). Furthermore, this therapeutic platform exhibited excellent performance in ablation of thrombus through photothermal therapy. As man-made micromotors, these biohybrid EM-JPMs hold great promise of navigating in vivo for active delivery while overcoming the drawbacks of existing synthetic therapeutic platforms. We expect that this biohybrid motor has considerable potential to be widely used in the biomedical field.

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“…Chitosan has three types of reactive groups in its structure: an amino group (-NH2) at position S-2, and primary and secondary hydroxyl groups (-OH) at positions S-3 and S-6 [36]. It is soluble in water at pH < 6.5 when it has a polycationic character that allows for interactions with oppositely charged surfactants and polymers to form coacervates that can be adsorbed at the interface of oil-in-water emulsions and form a microcapsule wall around the oil core [35,[37][38][39]. This phenomenon is known as complex coacervation and is an Pharmaceutics 2024, 16, 628 3 of 27 effective method for the microencapsulation of lipophilic active compounds due to the high payload, high encapsulation efficiency, and mild processing conditions [40,41].…”

Section: Introductionmentioning

confidence: 99%

Carbomer Hydrogels with Microencapsulated α-Tocopherol: Focus on the Biocompatibility of the Microcapsules, Topical Application Attributes, and In Vitro Release Study

Đekić,

Milinković Budinčić,

Stanić

et al. 2024

Pharmaceutics

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The microencapsulation of α-tocopherol based on the complex coacervation of low-molecular-weight chitosan (LMWC) and sodium lauryl ether sulphate (SLES) without harmful crosslinkers can provide biocompatible carriers that protect it from photodegradation and air oxidation. In this study, the influence of the microcapsule wall composition on carrier performance, compatibility with a high-water-content vehicle for topical application, and release of α-tocopherol were investigated. Although the absence of aldehyde crosslinkers decreased the encapsulation efficiency of α-tocopherol (~70%), the variation in the LMWC/SLES mass ratio (2:1 or 1:1) had no significant effect on the moisture content and microcapsule size. The prepared microcapsule-loaded carbomer hydrogels were soft semisolids with pseudoplastic flow behavior. The integrity of microcapsules embedded in the hydrogel was confirmed by light microscopy. The microcapsules reduced the pH, apparent viscosity, and hysteresis area of the hydrogels, while increasing their spreading ability on a flat inert surface and dispersion rate in artificial sweat. The in vitro release of α-tocopherol from crosslinker-free microcapsule-loaded hydrogels was diffusion-controlled. The release profile was influenced by the LMWC/SLES mass ratio, apparent viscosity, type of synthetic membrane, and acceptor medium composition. Better data quality for the model-independent analysis was achieved when a cellulose nitrate membrane and ethyl alcohol 60% w/w as acceptor medium were used.

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Tuning the formation and stability of microcapsules by environmental conditions and chitosan structure

Cited by 21 publications

References 51 publications

Electrostatically Complexed Natural Polysaccharides as Aqueous Barrier Coatings for Sustainable and Recyclable Fiber-Based Packaging

Electrostatically Complexed Natural Polysaccharides as Aqueous Barrier Coatings for Sustainable and Recyclable Fiber-Based Packaging

Erythrocyte Membrane Modified Janus Polymeric Motors for Thrombus Therapy

Carbomer Hydrogels with Microencapsulated α-Tocopherol: Focus on the Biocompatibility of the Microcapsules, Topical Application Attributes, and In Vitro Release Study

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