Turbid medium polarimetry in biomedical imaging and diagnosis

Abstract

Abstract. Studies on polarization properties of scattered light from a random medium like biological tissue have received considerable attention because polarization can be used as an effective tool to discriminate against multiply scattered light (acting as a gating mechanism) and thus can facilitate high resolution imaging through tissue. Further, the polarization properties of scattered light from tissue contain wealth of morphological and functional information of potential biomedical importance. However, in a complex random medium like tissue, numerous complexities due to multiple scattering and simultaneous occurrences of many scattering and polarization events present formidable challenges both in terms of accurate measurements and in terms of analysis of the tissue polarimetry signal. Several studies have therefore been conducted in the recent past to develop appropriate measurement procedures, suitable light propagation models and polarimetry signal analysis methods to overcome these difficulties. In this review, we focus on some of the recent key developments in this area. Specifically, we describe variety of theoretical and experimental tools, illustrated with selected results, aimed at evaluating the prospect of turbid medium polarimetry for both biomedical imaging and diagnosis.

Imaging through scattering media using semidefinite programming

“…19 Simulation and experimentation results validate that the proposed LSSDP outperforms than the PSIMSO and SPR in general. The work is expected to improve the image reconstruction quality for practical applications such as imaging through turbid media in biomedical, [22][23][24] and scattering property measurement of certain media, 24,25 such as fog and optical image encryption. 26,27 The rest of this paper is organized as follows: Sec.…”

Wavelet-based multifractal analysis of laser biopsy imagery

“…It is well known that the elastic scattering spectrum contains rich morphological information about the biological tissue samples due to the inhomogeneity of the constituent organelles' sizes. 8,14,[16][17][18][19][20][21][22][23][24][25][26][27][28] The angular and wavelength dependence of the elastic scattering spectra have been used to analyze such subtle variations in the morphological changes. 9,16,19,21,26,28 In this work, we perform a Monochromatic Transmission Imaging (MTI) of the tissue samples which provides us with small angle scattering information of the biological samples.…”

Fluorescent Mueller matrix analysis of a highly scattering turbid media

“…1-5 Although polarimetry is well suited for applications in optically clear media and for studies of surfaces; recent studies have shown that by suitable modifications in measurement and analysis methods, it can be applied to the highly turbid media as well. 6 As is known, multiple scattering in optically thick turbid media such as polymer nanoparticles and most biological tissues causes extensive depolarization that confounds the established techniques. 2,3,6 There have been several attempts showing that polarization properties of fluorescence scattering may provide additional information.…”

“…6 As is known, multiple scattering in optically thick turbid media such as polymer nanoparticles and most biological tissues causes extensive depolarization that confounds the established techniques. 2,3,6 There have been several attempts showing that polarization properties of fluorescence scattering may provide additional information. 7,8 However, these studies have considered similar approaches to the conventional measurements of the fluorescence polarization anisotropy, which is done using the linear polarization excitation only.…”