Turbulence downstream of subcoronary stentless and stented aortic valves

Funder, Jonas Amstrup; Frost, Markus Winther; Wierup, Per; Klaaborg, Kaj-Erik; Hjortdal, Vibeke E.; Nygaard, Hans; Hasenkam, J. Michael

doi:10.1016/j.jbiomech.2011.05.035

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…7). We also observe additional small-scale turbulent flow features at current spatial resolutions, which are also present in physiological flow regimes [57]. Re peak for both cases is approximately 20,000, which clearly motivates the need for further studies on the treatment of turbulence in these types of models.…”

Section: Discussionmentioning

confidence: 54%

Fluid–Structure Interaction Models of Bioprosthetic Heart Valve Dynamics in an Experimental Pulse Duplicator

Lee¹,

Rygg²,

Kolahdouz³

et al. 2019

Preprint

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Computer modeling and simulation (CM&S) is a powerful tool for assessing the performance of medical devices such as bioprosthetic heart valves (BHVs) that promises to accelerate device design and regulation. This study describes work to develop dynamic computer models of BHVs in the aortic test section of an experimental pulse duplicator platform that is used in academia, industry, and regulatory agencies to assess BHV performance. These computational models are based on a hyperelastic finite element extension of the immersed boundary method for fluid--structure interaction (FSI). We focus on porcine tissue and bovine pericardial BHVs, which are commonly used in surgical valve replacement. We compare our numerical simulations to experimental data from two similar pulse duplicators, including a commercial ViVitro system and a custom platform related to the ViVitro pulse duplicator. Excellent agreement is demonstrated between the computational and experimental results for bulk flow rates, pressures, valve open areas, and the timing of valve opening and closure in conditions commonly used to assess BHV performance. In addition, reasonable agreement is demonstrated for quantitative measures of leaflet kinematics under these same conditions. This work represents a step towards the experimental validation of this FSI modeling platform for evaluating BHVs.

show abstract

Section: Discussionmentioning

confidence: 54%

Fluid–Structure Interaction Models of Bioprosthetic Heart Valve Dynamics in an Experimental Pulse Duplicator

Lee¹,

Rygg²,

Kolahdouz³

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…We also observe additional small-scale turbulent flow features at current spatial resolutions, which are also present in physiological flow regimes. 23 Re peak for both cases is approximately 20,000, which clearly motivates the need for further studies on the treatment of turbulence in these types of models. In the present study, we perform implicit large-eddy simulation (ILES) using high-resolution slope limiters, based on the piecewise parabolic method, 14,15,45,57 to model the flow field.…”

Section: Biomedical Engineering Societymentioning

confidence: 89%

Fluid–Structure Interaction Models of Bioprosthetic Heart Valve Dynamics in an Experimental Pulse Duplicator

et al. 2020

View full text Add to dashboard Cite

Computer modeling and simulation is a powerful tool for assessing the performance of medical devices such as bioprosthetic heart valves (BHVs) that promises to accelerate device design and regulation. This study describes work to develop dynamic computer models of BHVs in the aortic test section of an experimental pulse-duplicator platform that is used in academia, industry, and regulatory agencies to assess BHV performance. These computational models are based on a hyperelastic finite element extension of the immersed boundary method for fluid–structure interaction (FSI). We focus on porcine tissue and bovine pericardial BHVs, which are commonly used in surgical valve replacement. We compare our numerical simulations to experimental data from two similar pulse duplicators, including a commercial ViVitro system and a custom platform related to the ViVitro pulse duplicator. Excellent agreement is demonstrated between the computational and experimental results for bulk flow rates, pressures, valve open areas, and the timing of valve opening and closure in conditions commonly used to assess BHV performance. In addition, reasonable agreement is demonstrated for quantitative measures of leaflet kinematics under these same conditions. This work represents a step towards the experimental validation of this FSI modeling platform for evaluating BHVs.

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Current status on stentless aortic bioprosthesis: a clinical and experimental perspective

Funder

2011

European Journal of Cardio-Thoracic Surgery

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Introduction of stentless valves into clinical practice has not replaced stented valve prosthesis as expected a decade ago. With respect to clinical parameters such as transvalvular pressure differences, left ventricular mass regression as well as a possible survival benefit, there are many contradictory studies published. The overall dilemma is the absence of large randomized studies. This review, therefore, focuses on two issues: Experimental research in order to disclose design advantages or drawbacks and clinical trials expressing the real benefit or risk for the patient. In general, both clinical and experimental studies show that stentless valves have several biomechanical and haemodynamic benefits when compared with stented valves though new generation pericardial valves have excellent blood flow profiles. However, stentless and stented valves seem to perform equally well when it comes to various clinical parameters. In most cases, a stented valve is therefore preferable because of the simpler implantation technique. In order to gain a more widespread clinical use, the design of the stentless valve needs to be improved in order to simplify the implantation.

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Turbulence downstream of subcoronary stentless and stented aortic valves

Cited by 3 publications

References 13 publications

Fluid–Structure Interaction Models of Bioprosthetic Heart Valve Dynamics in an Experimental Pulse Duplicator

Fluid–Structure Interaction Models of Bioprosthetic Heart Valve Dynamics in an Experimental Pulse Duplicator

Fluid–Structure Interaction Models of Bioprosthetic Heart Valve Dynamics in an Experimental Pulse Duplicator

Current status on stentless aortic bioprosthesis: a clinical and experimental perspective

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