Turcuron: A standardized bisacurone-rich turmeric rhizome extract for the prevention and treatment of hangover and alcohol-induced liver injury in rats

Sudeep, HV; Venkatakrishna, K.; K, Sundeep; Hs, Vasavi; Raj, Amritha; Chandrappa, S.; Shyamprasad, K

doi:10.4103/pm.pm_32_20

Cited by 5 publications

(4 citation statements)

References 29 publications

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“…Feeding mice with bisacurone reduced total lipid, triglyceride, and cholesterol levels in the liver [10]. C. longa extracts containing bisacurone suppress the development of ethanol-induced liver injury [11,12] and non-alcoholic fatty liver disease (NAFLD) [13] in murine models by reducing serum levels of pro-inflammatory cytokines, such as IL-6 and TNF-α, and improving liver weight, fat accumulation, and levels of biochemical markers, such as serum cholesterol and aspartate aminotransferase (AST)/alanine aminotransferase (ALT). A randomized, double-blind intervention trial involving middleaged and elderly subjects with overweight or mild hypertension showed that a hot water extract of C. longa containing bisacurone decreased the serum levels of C-reactive protein, IL-6, TNF-α, and VCAM-1 [14].…”

Section: Introductionmentioning

confidence: 99%

Hypolipidemic and Anti-Inflammatory Effects of Curcuma longa-Derived Bisacurone in High-Fat Diet-Fed Mice

Miyazawa

Abe

et al. 2023

IJMS

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Turmeric (Curcuma longa) contains various compounds that potentially improve health. Bisacurone is a turmeric-derived compound but has been less studied compared to other compounds, such as curcumin. In this study, we aimed to evaluate the anti-inflammatory and lipid-lowering effects of bisacurone in high-fat diet (HFD)-fed mice. Mice were fed HFD to induce lipidemia and orally administered bisacurone daily for two weeks. Bisacurone reduced liver weight, serum cholesterol and triglyceride levels, and blood viscosity in mice. Splenocytes from bisacurone-treated mice produced lower levels of the pro-inflammatory cytokines IL-6 and TNF-α upon stimulation with a toll-like receptor (TLR) 4 ligand, lipopolysaccharide (LPS), and TLR1/2 ligand, Pam3CSK4, than those from untreated mice. Bisacurone also inhibited LPS-induced IL-6 and TNF-α production in the murine macrophage cell line, RAW264.7. Western blot analysis revealed that bisacurone inhibited the phosphorylation of IKKα/β and NF-κB p65 subunit, but not of the mitogen-activated protein kinases, p38 kinase and p42/44 kinases, and c-Jun N-terminal kinase in the cells. Collectively, these results suggest that bisacurone has the potential to reduce serum lipid levels and blood viscosity in mice with high-fat diet-induced lipidemia and modulate inflammation via inhibition of NF-κB-mediated pathways.

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Section: Introductionmentioning

confidence: 99%

Hypolipidemic and Anti-Inflammatory Effects of Curcuma longa-Derived Bisacurone in High-Fat Diet-Fed Mice

Miyazawa

Abe

et al. 2023

IJMS

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“…Bisacurone is known for its various pharmacological potential as it inhibits ROS generation and prevents tumor necrosis factor-alpha (TNF-α)-induced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation 12 . Bisacurone also exhibits anti-inflammatory properties, thus inhibiting inflammatory proteins such as TNF, inducible nitric oxide (iNOS), and cyclooxygenase-2 (COX-2) 13 . According to a previous study, bisacurone is known to down-regulate the expression of vascular cell adhesion molecules, inhibiting ROS in TNF-α-stimulated human umbilical vein endothelial cells (HUVECs) 14 .…”

Section: Introductionmentioning

confidence: 99%

Bisacurone gel ameliorated burn wounds in experimental rats via its anti-inflammatory, antioxidant, and angiogenic properties

Yan,

Li,

Gong

2023

Acta Cir. Bras.

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Purpose: To investigate putative mechanism of wound healing for chitosan-based bisacurone gel against secondary burn wounds in rats. Methods: A second-degree burn wound with an open flame using mixed fuel (2 mL, 20 seconds) was induced in Sprague Dawley rats (male, 180-220 g, n = 15, each) followed by topical treatments with either vehicle control (white petroleum gel, 1%), silver sulfadiazine (1%) or bisacurone gel (2.5, 5, or 10%) for 20 days. Wound contraction rate and paw withdrawal threshold were monitored on various days. Oxidative stress (superoxide dismutase, glutathione, malondialdehyde, and nitric oxide), pro-inflammatory cytokines (tumour necrosis factor-alpha, interleukins by enzyme-linked immunosorbent assay), growth factors (transforming growth factor-β, vascular endothelial growth factor C using real time polymerase chain reaction and Western blot assay) levels, and histology of wound skin were assessed at the end. Results: Bisacurone gel showed 98.72% drug release with a 420.90–442.70 cps viscosity. Bisacurone gel (5 and 10%) significantly ( p < 0.05) improved wound contraction rate and paw withdrawal threshold. Bisacurone gel attenuated oxidative stress, pro-inflammatory cytokines, and water content. It also enhanced angiogenesis (hydroxyproline and growth factor) and granulation in wound tissue than vehicle control. Conclusions: These findings suggested that bisacurone gel can be a potential candidate to treat burn wounds via its anti-inflammatory, antioxidant, and angiogenic properties.

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“…However, long-term, heavy alcohol consumption can cause hangovers and other health issues including hepatitis, liver cirrhosis and fatty liver, muscle pain, etc. [1][2][3]. A meta-analysis and case-cohort study indicated that heavy alcohol drinking is associated with being a major risk factor for gastric cancer [4,5].…”

Section: Introductionmentioning

confidence: 99%

Protective Effect and Potential Antioxidant Role of Kakadu Plum Extracts on Alcohol-Induced Oxidative Damage in HepG2 Cells

et al. 2021

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Serial alcohol consumption causes alcoholic liver disease (ALD), which can lead to fatty liver, hepatitis, and cirrhosis. Terminalia ferdinandiana (Kakadu plum) is an indigenous fruit of Australia, which is utilized as a functional food. It is a commercially important antioxidant as it contains a more eloquent level of ascorbic acid than other oranges. In this study, we analyzed the chemical constituents of vitamin C, gallic acid, ellagic acid, and daidzin via High-performance liquid chromatography (HPLC) in the Kakadu plum from two different regions including the Northern Territory (NT) and Western Australia (WA), and compared their biochemical properties. The vitamin C content was much higher (almost 70%) in Kakadu plum (KKD) from the NT than WA. Moreover, ROS generation was inhibited significantly in HepG2 (human hepatoma) cells with the KKD-NT extract treatment when compared to the KKD-WA extract treatment. The cytotoxicity produced by ethanol was significantly suppressed in response to the treatment with both of the samples. In addition, our samples (KKD-NT and KKD-WA) increased the activity of two key enzymes involving alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) that metabolize ethanol. These results show the biochemical confirmation of the mechanism by which KKD exhibits its biological functions including relief from alcohol hangovers as well as protection of the liver cells by the suppression of ROS production and toxic insults.

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Turcuron: A standardized bisacurone-rich turmeric rhizome extract for the prevention and treatment of hangover and alcohol-induced liver injury in rats

Cited by 5 publications

References 29 publications

Hypolipidemic and Anti-Inflammatory Effects of Curcuma longa-Derived Bisacurone in High-Fat Diet-Fed Mice

Hypolipidemic and Anti-Inflammatory Effects of Curcuma longa-Derived Bisacurone in High-Fat Diet-Fed Mice

Bisacurone gel ameliorated burn wounds in experimental rats via its anti-inflammatory, antioxidant, and angiogenic properties

Protective Effect and Potential Antioxidant Role of Kakadu Plum Extracts on Alcohol-Induced Oxidative Damage in HepG2 Cells

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