Türkiye’deki Holştayn, İsviçre Esmeri ve Simmental Sığır Irklarında Kapa-Kazein, Büyüme Hormonu ve Prolaktin Genlerinin Allel Frekansları

Akyüz, Bilal; Arslan, Korhan; Bayram, Davut; Işcan, Kaan M.

doi:10.9775/kvfd.2012.7985

Cited by 5 publications

(1 citation statement)

References 17 publications

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“…These polymorphisms may be important for the improvement of reproductive traits. Gene regions effect reproductive and productive traits should be also investigated in native breeds to reveal genetic composition of these breeds as some investigation groups have already done [53,54] .…”

Section: As It Is Seen Inmentioning

confidence: 99%

Holstein-Friesian Düvelerde Fertilite ile GH, PRL, STAT5A, OPN, PIT-1, LEP ve FGF2 Polimorfizimlerinin İlişkileri

Öner¹,

Yılmaz²,

Okut³

et al. 2017

Kafkas Univ Vet Fak Derg

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In this study, it was aimed to investigate polymorphisms in seven genes (GH, PRL, STAT5A, OPN, LEP and FGF2) related to reproductive traits in dairy heifers. Frequency distributions of the genotypes between fertile and repeat breeder heifers groups were investigated. Allele effects on fertility were also analyzed. Blood samples were taken from a total of 160 Holstein-Friesian heifers and they were divided into two groups according to their artificial insemination numbers (AI). The heifers becoming pregnant after the first AI were used as the fertile heifers (FH, n=80) and the heifers with 3 or more equal AIs were accepted as the repeat breeder heifers (RBH, n=80). All the animals were genotyped by the PCR-RFLP method for seven genes and the association works were performed for 145 animals (RBH, n=79; FH n=66). For all loci investigated, two alleles and three genotypes were found for overall population with the exception that PRL locus had two alleles and two genotypes. The chi-square test (χ 2 ) revealed that the whole population and the two groups separately were at Hardy-Weinberg equilibrium. The genotype distributions of PIT-1 and STAT5A conspicuously differed between the FH and the RBH groups; however, these differences were not found significant. Association of GH-AB genotype was found significant on AI number for the first pregnancy. Mixed effect logistic regression model was used to investigate the allele effects on fertility. No linkage disequilibrium was detected between the investigated loci. Keywords

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Section: As It Is Seen Inmentioning

confidence: 99%

Holstein-Friesian Düvelerde Fertilite ile GH, PRL, STAT5A, OPN, PIT-1, LEP ve FGF2 Polimorfizimlerinin İlişkileri

Öner¹,

Yılmaz²,

Okut³

et al. 2017

Kafkas Univ Vet Fak Derg

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Relationship between genetic polymorphism of κ-casein and quantitative milk yield traits in cattle breeds and crossbreds in Serbia

Djedović¹,

Bogdanović²,

Perisic³

et al. 2015

Genetika

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The quality and yield of milk, and therefore of dairy products as well, depends directly on their protein composition. Milk gene proteins represent structural locuses that are functionally associated with milk production. In cattle selection a special importance is attached to the variability of kappa casein (?-CN) as one of the four casein milk proteins. Genotypes of 21 Simmental breed cows, 20 crossbred cows obtained by crossing of Simmental and Red Holstein breed, and 25 cows of autochthonous Busha breed were determined for kappa casein by restriction fragment length polymorphism analysis (PCR- RFLP) of amplified DNA. The ?-CN genotype frequencies for Simmental breed were: 42.8; 47.6 and 9.6 % for AA, and BB genotype, for crossbreds: 75.0; 25.0 and 0.0% and for Busha individuals: 41.7; 50.0 and 8.3 %, respectively. Frequencies of A and B alleles, assessed on the basis of genotypic frequencies were 0.667 and 0.333 for Simmental breed, 0.875 and 0.125 for crossbreds and 0.667 and 0.333 for autochthonous Busha cattle breed, respectively. For confirming the phenotypic variability of milk yield in standard lactation, yield of milk fat and the content of milk fat per ?-CN genotypes within breeds observed the fixed model which included the breed effect, lactation in order and effect of ?-CN genotype (AA, and BB) was used. The ?-CN genotype statistically significantly (p ?0.05) influenced milk yield and highly significantly (p ?0.01) milk fat yield, while the content of milk fat was not statistically significantly (p>0.05) influenced in examined animals.

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Growth hormone (GH), prolactin (PRL), and diacylglycerol acyltransferase (DGAT1) gene polymorphisms in Turkish native cattle breeds

Ünal¹,

Kepenek²,

Dinç³

et al. 2015

Turk J Zool

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IntroductionGenetic research in farm animals focuses mainly on the identification of genes influencing economically important traits that could be useful in breeding programs. In dairy cattle, most studies have researched the genes that may determine variations in milk yield and milk composition (Komisarek and Dorynek, 2009). The polymorphisms of several genes including growth hormone (GH), prolactin (PRL), and diacylglycerol acyltransferase (DGAT1) have been shown to affect milk yield and milk composition traits in dairy cattle.GH belongs to a family of somatolactogenic hormones including prolactin, placental lactogen, and a number of hematopoietic growth factors (Cosman et al., 1990). GH is located on the 19th chromosome in the q26-qter band region (Hediger et al., 1990). The GH gene of cattle is approximately 1800 bp in size and contains 5 exons and 4 introns. This gene encodes an mRNA with a size of 786 bp (Woychik et al., 1982). Although a number of polymorphisms have been observed in the GH gene of cattle, the 2 polymorphisms that are located in intron 3 and exon 5 have been found to be significant in their effects on milk and meat yield parameters (Lucy et al., 1991(Lucy et al., , 1993Høj et al., 1993). The polymorphism in intron 3 of GH is observed when GH is digested by the restriction enzyme MspI (GH-MspI) (Zhang et al., 1993). Two alleles are observed as a result of digestion with this enzyme. The first allele, GH-MspI ( -) contains a T insertion at the +837 position, and the second allele has a C-G transition at the +837 position (Lee et al., 1994). Zhang et al. (1993b) reported that the polymorphism in exon 5 could be observed when digested by the AluI enzyme (GH-AluI) and the 2 alleles called L (leucine in the 127th codon) and V (valine in the 127th codon) occur.The PRL gene is located on chromosome 23 and is composed of 5 exons and 4 introns (Camper et al., 1984, as cited by Skinkyte et al., 2005. A silent A-G mutation of the 103rd codon in exon 3 of the bovine PRL gene led to a polymorphic RsaI site (Lewin, 1992, as cited by Skinkyte et al., 2005). The polymorphism leading to the RsaI enzyme restriction site of the bovine PRL gene determines milk production traits including milk yield, milk fat, and milk protein contents (Lewin et al., 1992). The significant effect of the PRL locus on milk production traits was later shown by Chung et al. (1996, as cited by Dybus, 2002a as well.

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Türkiye’deki Holştayn, İsviçre Esmeri ve Simmental Sığır Irklarında Kapa-Kazein, Büyüme Hormonu ve Prolaktin Genlerinin Allel Frekansları

Cited by 5 publications

References 17 publications

Holstein-Friesian Düvelerde Fertilite ile GH, PRL, STAT5A, OPN, PIT-1, LEP ve FGF2 Polimorfizimlerinin İlişkileri

Holstein-Friesian Düvelerde Fertilite ile GH, PRL, STAT5A, OPN, PIT-1, LEP ve FGF2 Polimorfizimlerinin İlişkileri

Relationship between genetic polymorphism of κ-casein and quantitative milk yield traits in cattle breeds and crossbreds in Serbia

Growth hormone (GH), prolactin (PRL), and diacylglycerol acyltransferase (DGAT1) gene polymorphisms in Turkish native cattle breeds

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