Turmeric(Curcuma longa): An Evidence-Based Systematic Review by the Natural Standard Research Collaboration

Herb–drug interactions: an overview of systematic reviews

“…Our searches generated 4366 articles, of which 4320 had to be excluded (Figure 1). Thus 46 SRs met our inclusion criteria (Table 1) [9–54]. The following herbs were considered to interact with synthetic drugs: Aloe vera, Boswellia serrata, Calendula officinalis, Camellia sinensis, Cassia senna, Caulophyllum thalictroides, Cinnamomum spp.…”

“…The following drugs interacted with HMPs (Table 2): anaesthetics [16], anti‐arrhythmic agents [15, 27], antibiotics [19, 34, 36, 39, 40, 42, 46, 48, 49, 52, 53], anticoagulants [13, 15, 16, 18, 24, 26, 27, 29, 33, 34, 36, 37, 39, 40, 44–46, 49, 50, 52, 53], anticholinergics [17, 22], antidepressants [25, 26, 33, 45], antidiabetics [26, 27, 38, 40, 43, 47, 50–53], antihypertensives [16, 29, 33, 41, 43–46, 49, 53], anti‐inflammatory agents [13, 16, 35, 46, 52, 53], antimicrobials [31], antineoplastics [11, 14, 31, 36, 39–43, 51–53], antiplatelet agents [13, 15, 24, 25, 27, 29, 33, 34, 36, 37, 39, 40, 44, 45, 49, 50, 52, 53], anti‐epileptic drugs [13, 41, 45], antivirals [31, 40, 45, 51, 52], calcium channel blockers [24, 26, 30], cholesterol lowering agents [10, 13, 24, 26, 27, 40, 41, 44, 45, 50, 53], CYP‐450 metabolized agents [18, 21, 25, 29, 32, 34, 40, 42, 45, 48, 49, 53], diuretics [26, 30, 43], hormonal agents [18, 24, 26, 31, 40, 41, 43, 45, 49, 53, 54], hypoglycaemics [9, 10, 19, 20, 28], immunnosupressants [31, 34, 37, 40, 43, 46, 48] laxatives [27, 37, 50], leukotriene inhibitors [14], sedatives [12, 13, 23, 25, 45], selective serotonin re‐uptake inhibitors [23, 33] and vasolidators [30, 44].…”

“…The most common interacting drugs were anticoagulants [13, 15, 16, 18, 24, 26, 27, 29, 33, 34, 36, 37, 39, 40, 44-46, 49, 50, 52, 53] and antiplatelet agents [13,15,24,25,27,29,33,34,36,37,39,40,44,45,49,50,52,53].The most probable mechanisms of these interactions involve an inhibition of thromboxane synthesis and cyclooxygenase. Some herbs acted as inhibitors/antagonists of drugs [16,21,22,31] whereas others acted as agonists/synergists [9-13, 17, 20, 28-30, 34-36, 38-40, 47, 50, 51, 54].…”

“…Rosemary ( The following drugs interacted with HMPs ( Table 2): anaesthetics [16], anti-arrhythmic agents [15,27], antibiotics [19,34,36,39,40,42,46,48,49,52,53], anticoagulants [13, 15, 16, 18, 24, 26, 27, 29, 33, 34, 36, 37, 39, 40, 44-46, 49, 50, 52, 53], anticholinergics [17,22], antidepressants [25,26,33,45], antidiabetics [26,27,38,40,43,47,[50][51][52][53], antihypertensives [16, 29, 33, 41, 43-46, 49, 53], anti-inflammatory agents [13,16,35,46,52,53], antimicrobials [31], antineoplastics [11,14,31,36,[39][40][41]…”

Effectiveness of curcuminoids in the treatment of knee osteoarthritis: a systematic review and meta‐analysis of randomized clinical trials

“…Our results support the results of a previous review which concluded that curcuminoids are as effective as ibuprofen in the treatment of OA. 47 In contrast to that report, our review included at least four studies that were not available for inclusion in the review, included only studies with curcuminoids as sole supplement, and statistically combined data. Our results also corroborate the conclusions of two recent reviews which suggested beneficial effects of curcuminoids in the treatment of OA.…”