Turmeric Supplementation Improves Serum Glucose Indices and Leptin Levels in Patients with Nonalcoholic Fatty Liver Diseases

Abstract

Turmeric supplementation improved glucose indexes and serum leptin levels and may be useful in the control of NAFLD complications.

Does turmeric/curcumin supplementation improve serum alanine aminotransferase and aspartate aminotransferase levels in patients with nonalcoholic fatty liver disease? A systematic review and meta‐analysis of randomized controlled trials

“…After reading the full text of the remaining 10 studies, four studies were also excluded for the following reasons: two studies did not report data on liver enzymes (Basu et al, ; Jazayeri‐Tehrani et al, ), one study was a duplicate report (Ghaffari, Rafraf, Navekar, & Asghari‐Jafarabadi, ), and one study was published as protocol (Jazayeri‐Tehrani et al, ). Finally, six eligible RCTs (Chirapongsathorn et al, ; Jarahzadeh & Hosain, ; Moradi et al, ; Navekar et al, ; Panahi et al, ; Rahmani et al, ) were included in our analysis. A flowchart of the systematic search and study selection process is presented in Figure .…”

The effects of curcumin supplementation on body mass index, body weight, and waist circumference in patients with nonalcoholic fatty liver disease: A systematic review and dose–response meta‐analysis of randomized controlled trials

“…We excluded nine other studies because of the following reasons: (a) Seven articles were derived from the same trials and reported the same outcomes. We included the most complete ones to avoid double weighting in the estimates derived from the same studies (Jazayeri‐Tehrani et al, ; Navekar et al, ; Saadati et al, ). (b) Trials without placebo or control group were excluded ( n = 2; Panahi, Kianpour, Mohtashami, Soflaei, & Sahebkar, ).…”

“…In the overall pooled estimate of eight trials (Chashmniam et al, ; Cicero et al, ; Jazayeri‐Tehrani et al, ; Mirhafez et al, ; Navekar et al, ; Panahi et al, ; Rahmani et al, ; Saadati et al, ) with 520 participants (a dose ranging from 70 to 3,000 mg/day), it was shown that curcumin supplementation was associated with a significant reduction in BMI (WMD = −0.34 kg/m 2 , 95% CI [−0.64, −0.04], p < .05) compared with the control group (Figure ). The heterogeneity among trials investigating the effect of curcumin supplementation on BMI was high ( I 2 = 63.2%, p < .01).…”

“…Sex studies including a total of 353 participants (curcumin group = 181 and control group = 172) reported body weight as an outcome measure (Chashmniam et al, ; Jazayeri‐Tehrani et al, ; Mirhafez et al, ; Navekar et al, ; Rahmani et al, ; Saadati et al, ). Combined results from the random‐effects model showed that curcumin supplementation had no significant effect on body weight (WMD = −0.60 kg, 95% CI [−2.07, 0.87], p = .423) with significant heterogeneity among the studies ( I 2 = 81.8%, p < .001; Figure ).…”

“…Chronic systemic inflammation has been proposed as the main factor in the development and progression of several noncommunicable diseases, including metabolic syndrome, cardiovascular diseases, obesity, and cancer (Namazi, Larijani, & Azadbakht, ). Several mechanisms have been proposed for effects of anti‐inflammatory diets and their ingredients such as curcumin on obesity and WC including inhibition of the lipogenesis and inflammation (reducing proinflammatory cytokines), suppressing angiogenesis in adipose tissue, downregulating preadipocyte differentiation, increasing lipolysis, brown fat tissue, adipocyte energy metabolism and apoptosis, serum levels of nesfatin, and probiotics‐like effects (Jin, Song, Weng, & Fantus, ; Navekar et al, ; Zhang, Fu, Gao, & Liu, ). The effects of nesfatin include appetite loss, reducing body fat, anti‐inflammation, antihyperglycemic, metabolic, and neuroendocrine regulation (Dong et al, ; Shen, Han, Cai, & Wang, ).…”