Turn-off/on fluorescent sensors for Cu<sup>2+</sup> and ATP in aqueous solution based on a tetraphenylethylene derivative

Geng, Lai-Yao; Zhao, Yang; Kamya, Edward; Guo, Jintang; Sun, Bin; Feng, Yakai; Zhu, Meifang; Ren, Xiang‐Kui

doi:10.1039/c8tc06075d

Cited by 35 publications

(10 citation statements)

References 31 publications

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“…When these fluorophore molecules attach with metal ions, the solution phase exhibits fluorescence. Because the free rotation of the fluorophore molecules is restricted by the attachment of metal ions, that is, the molecules are aggregated with each other, radiative pathways are initiated [43].…”

Section: Aggregation-induced Emission (Aie)mentioning

confidence: 99%

“…However, Cu 2+ tends to form a complex with TPE-CO 2 H and disturbs TPE-CO 2 H aggregates, quenching the fluorescence. Finally, a turn-off fluorescence strategy was developed for detecting Cu 2+ , and the LOD was 20 µM [43]. Interestingly, a BODIPY-based turnoff chemosensor (BODIPY-17) was used in Cu 2+ detection because of its good water solubility and strong absorption and emission bands (400-750 nm).…”

Section: Cu 2+ Ion Detectionmentioning

confidence: 99%

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Paper-Based Fluorescence Chemosensors for Metal Ion Detection in Biological and Environmental Samples

Sivakumar

Lee

2021

BioChip J

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The recognition and detection of metal ions present in biological and environmental samples have attracted great attention in recent years. Various analytical techniques are used to detect metal ions. Among these, the fluorescence technique is among the emerging methods because of its simplicity, selectivity, and applicability to bioimaging. Thus, this review particularly explores paper-based fluorescence chemosensors involved in metal ion detection. Significantly, the first section addresses relevant research on metal ion detection involving various techniques. In the second section, several sensing strategies such as photoinduced electron transfer, fluorescence resonance energy transfer, intramolecular charge transfer, chelation enhanced fluorescence, excited-state intramolecular proton transfer, and aggregation-induced emission for the detection of target metal ions (aluminum, copper, iron, lead, mercury, and zinc) are investigated. The third section particularly discusses the role of fluorescence sensor materials (e.g., fluorescein, rhodamine, naphthalimide, BODIPY, carbon dots, quantum dots) involved in the detection processes and their advantages and limitations. Overall, this article reviews 90 research articles on paperbased fluorescence chemosensors for metal ion detection published until 2021.

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Section: Aggregation-induced Emission (Aie)mentioning

confidence: 99%

Section: Cu 2+ Ion Detectionmentioning

confidence: 99%

Paper-Based Fluorescence Chemosensors for Metal Ion Detection in Biological and Environmental Samples

Sivakumar

Lee

2021

BioChip J

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“…Therefore, the sensitive and precise determination of UA is significant in, for instance, disease screening and physiological studies [ 5 ]. In recent years, many methods have been developed for the estimation and detection of UA levels, such as enzymatic assays [ 6 , 7 ], electrochemical sensors [ 8 , 9 , 10 , 11 ], spectrophotometric methods [ 12 , 13 , 14 , 15 ], Raman spectroscopy [ 16 ], chromatography [ 17 , 18 , 19 ], and fluorescent spectrometry [ 20 , 21 , 22 , 23 , 24 ]. Although enzymatic assays are the conventional method for the detection of UA, this method has challenges, including the high purification costs and the thermal instability of enzyme.…”

Section: Introductionmentioning

confidence: 99%

A Novel Turn-On Fluorescence Probe Based on Cu(II) Functionalized Metal–Organic Frameworks for Visual Detection of Uric Acid

et al. 2022

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As an important biomarker in urine, the level of uric acid is of importance for human health. In this work, a Cu(II) functionalized metal–organic framework (Cu2+@Tb-MOFs) is designed and developed as a novel fluorescence probe for wide-range uric acid detection in human urine. The study shows that this fluorescence platform demonstrated excellent pH-independent stability, high water tolerance, and good thermal stability. Based on the strong interaction between metal ions and uric acid, the designed Cu2+@Tb-MOFs can be employed as efficient turn-on fluorescent probes for the detection of uric acid with wide detection range (0~104 µM) and high sensitivity (LOD = 0.65 µM). This probe also demonstrates an anti-interference property, as other species coexisted, and the possibility for recycling. The sensing mechanisms are further discussed at length. More importantly, we experimentally constructed a molecular logic gate operation based on this fluorescence probe for intelligent detection of uric acid. These results suggest the Cu(II) functionalized metal–organic framework can act as a prominent candidate for personalized monitoring of the concentration of uric acid in the human urine system.

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“…Notably, tetraphenylethylene derivative-based fluorescent sensors have been strategically prepared for the rapid detection of Cu(II), wherein turn-off fluorescence is ascribed to the disassembly of tetraphenylethylene-COOH aggregates. 21 In another work, −N and −OH functionalities of a Schiff base sensor form a stable Cu(II) complex via coordination, resulting in the emission quenching of probe solution. 22 Because of the intrinsic paramagnetic nature of Cu(II), the fluorescence quenching of NTFP3 would occur in the presence of Cu(II).…”

Section: ■ Introductionmentioning

confidence: 99%

Ratiometric pH Sensing, Photophysics, and Cell Imaging of Nonaromatic Light-Emitting Polymers

Roy

Chowdhury

Sanfui

et al. 2022

ACS Appl. Bio Mater.

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Here, four nontraditional fluorescent polymers (NTFPs) of varying N,N-dimethyl-2-propenamide (DMPA) and butyl prop-2-enoate (BPE) mole ratios, i.e., 2:1 (NTFP1), 4:1 (NTFP2), 8:1 (NTFP3), and 16:1 (NTFP4), are prepared via random polymerization in water. The maximum fluorescence enhancement of NTFP3 makes it suitable for ratiometric pH sensing, Cu(II) sensing, and pH-dependent cell imaging of Madin-Darby canine kidney (MDCK) cells. The oxygen donor functionalities of NTFP3 involved in binding and sensing with Cu(II) ions are studied by absorption, emission, electron paramagnetic resonance, Fourier transform infrared (FTIR), and O1s/ Cu2p X-ray photoelectron spectroscopies (XPS). The spectral responses of the ratiometric pH sensor within 1.5−11.5 confirm 22 and 44 nm red shifts in absorption and ratiometric emission, respectively. The striking color changes from blue (436 nm) to green (480 nm) via an increase in pH are thought to be the stabilization of the charged canonical form of tertiary amide, i.e., −C(O − ) N + (CH 3 ) 2 , realized from the changes in the absorption/fluorescence spectra and XPS/FTIR analyses. The through-space n−π* interactions in the NTFP3 aggregate, N-branching-associated rigidity, and nonconventional intramolecular hydrogen bondings of adjacent NTFP3 moieties in the NTFP3 aggregate contribute to aggregation-enhanced emissions (AEEs). Here, structures of NTFP3, NTFP3 aggregate, and Cu(II)-NTFP3; absorption; n−π* interactions; hydrogen bondings; AEEs; and binding with Cu(II) are ascertained by density functional theory, time-dependent density functional theory, and reduced density gradient calculations. The excellent limits of detection and Stern−Volmer constants of NTFP3 are 2.24 nM/0.14234 ppb and 4.26 × 10 3 M −1 at pH = 6.5 and 0.95 nM/0.06037 ppb and 4.90 × 10 3 M −1 at pH = 8.0, respectively. Additionally, the Stokes shift and binding energy of NTFP3 are 13,636 cm −1 /1.69 eV and −4.64 eV, respectively. The pH-dependent MDCK cell imaging ability of noncytotoxic NTFP3 is supported via fluorescence imaging and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.

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Turn-off/on fluorescent sensors for Cu²⁺ and ATP in aqueous solution based on a tetraphenylethylene derivative

Abstract: Two novel fluorescent sensors based on a tetraphenylethylene derivative (TPE-COOH) were designed and prepared for the rapid detection of cupric ion and adenosine triphosphate (ATP) in 100% aqueous solution.

Cited by 35 publications

References 31 publications

Paper-Based Fluorescence Chemosensors for Metal Ion Detection in Biological and Environmental Samples

Paper-Based Fluorescence Chemosensors for Metal Ion Detection in Biological and Environmental Samples

A Novel Turn-On Fluorescence Probe Based on Cu(II) Functionalized Metal–Organic Frameworks for Visual Detection of Uric Acid

Ratiometric pH Sensing, Photophysics, and Cell Imaging of Nonaromatic Light-Emitting Polymers

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Turn-off/on fluorescent sensors for Cu2+ and ATP in aqueous solution based on a tetraphenylethylene derivative

Abstract: Two novel fluorescent sensors based on a tetraphenylethylene derivative (TPE-COOH) were designed and prepared for the rapid detection of cupric ion and adenosine triphosphate (ATP) in 100% aqueous solution.

Cited by 35 publications

References 31 publications

Paper-Based Fluorescence Chemosensors for Metal Ion Detection in Biological and Environmental Samples

Paper-Based Fluorescence Chemosensors for Metal Ion Detection in Biological and Environmental Samples

A Novel Turn-On Fluorescence Probe Based on Cu(II) Functionalized Metal–Organic Frameworks for Visual Detection of Uric Acid

Ratiometric pH Sensing, Photophysics, and Cell Imaging of Nonaromatic Light-Emitting Polymers

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Turn-off/on fluorescent sensors for Cu²⁺ and ATP in aqueous solution based on a tetraphenylethylene derivative