1999
DOI: 10.1111/j.1651-2227.1999.tb14419.x
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Turner syndrome: a pattern of early growth failure

Abstract: The purpose of this study was to determine the pattern of early growth in girls with Turner syndrome. Analysis was performed on a total of 464 longitudinal measurements of height, obtained from birth to 8 years of age from 37 girls with Turner syndrome who did not have significant cardiac disease or autosomal abnormalities. All data were obtained prior to the initiation of any hormonal therapy. Mean height SDS fell from ‐0.5 at birth to ‐1.5 at age 1 year and ‐1.8 at age 1.5 years. Growth curves fitted using t… Show more

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Cited by 51 publications
(27 citation statements)
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“…In our children, mean birthweight and birth length (total and each group separately) exceeded the reported mean weight of 2,180 g and birth length of 48.6 cm in TS [1]. Plotting of heights of X/XY children after bilateral gonadectomy on a female growth curve will underestimate degree of growth failure.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In our children, mean birthweight and birth length (total and each group separately) exceeded the reported mean weight of 2,180 g and birth length of 48.6 cm in TS [1]. Plotting of heights of X/XY children after bilateral gonadectomy on a female growth curve will underestimate degree of growth failure.…”
Section: Discussionmentioning
confidence: 99%
“…The growth pattern of children with X/XY has not been well described. In contrast, it is well known that girls with TS manifest mild intrauterine growth retardation, slow growth during infancy, delayed onset of the childhood component of growth, slow growth during childhood and failure to undergo a normal pubertal growth spurt [1]. The mean height of 37 TS children who had no significant disease or autosomal abnormality fell below the 5th percentile (–1.67 SD) by 13 months of age [1].…”
Section: Introductionmentioning
confidence: 99%
“…1,2,4,5 Because of delayed epiphyseal closure, small gains in height may occur even after 20 years of age. Average height is rarely achieved, except in girls with mosaicism (the presence in an individual of 2 or more chromosomally different cell lines, both originating from the same zygote) or those whose parents are of above average height.…”
Section: Phenotypementioning
confidence: 99%
“…In about 50% of cases, karyotype analysis of peripheral lymphocytes reveals the complete loss of one of the sex chromosomes (45, X), whereas the remaining patients display mosaicism and/or structural aberrations of sex chromosomes. TS is characterized by short stature, gonadal dysgenesis, webbed neck, high arched palate, cubitus valgus, short metacarpals, Madelung deformity, low-set ears, and other somatic stigmata [2,3]. Short stature remains one of the most investigated characteristic of TS and is a feature that may be present during fetal development, as well as after birth [3].…”
Section: Introductionmentioning
confidence: 99%