Twelve-Year Follow-Up of Laser In Situ Keratomileusis for Moderate to High Myopia

Abstract

Purpose To assess the long-term clinical outcomes of conventional laser in situ keratomileusis (LASIK) for moderate to high myopia. Methods We retrospectively examined sixty-eight eyes of 37 consecutive patients who underwent conventional LASIK for the correction of myopia (−3.00 to −12.75 diopters (D)). At 3 months and 1, 4, 8, and 12 years postoperatively, we assessed the safety, efficacy, predictability, stability, mean keratometry, central corneal thickness, and adverse events. Results The safety and efficacy indices were 0.82 ± 0.29 and 0.67 ± 0.37, respectively, 12 years postoperatively. At 12 years, 53% and 75% of the eyes were within 0.5 and 1.0 D, respectively, of the targeted correction. Manifest refraction changes of −0.74 ± 0.99 D occurred from 3 months to 12 years after LASIK (p < 0.001). We found a significant correlation of refractive regression with the changes in keratometric readings from 3 months to 12 years postoperatively (Pearson correlation coefficient, r = −0.28, p = 0.02), but not with the changes in central corneal thickness (r = −0.08, p = 0.63). No vision-threatening complications occurred in any case. Conclusions Conventional LASIK offered good safety outcomes during the 12-year observation period. However, the efficacy and the predictability gradually decreased with time owing to myopic regression in relation to corneal steepening.

Refractive, visual, and subjective quality of vision outcomes for very high myopia LASIK from − 10.00 to − 13.50 diopters

“…This table reports data before retreats respectively ( Fig. 1f), which is comparable or better than other lower myopia studies [9,16,[23][24][25][26][27][28][29][30][31][32] (Table 3). A better measure of regression effect, than the traditionally reported postoperative SEQ, is the amount of myopic development postoperatively.…”

Single-step Transepithelial photorefractive keratectomy in the treatment of mild, moderate, and high myopia: six month results

“…Serrao S et al [ 16 ] reported the safety index of the high myopia eyes treated by PRK was 0.81 one year postoperatively. Ikeda T et al [ 17 ] found 77% of high myopic eyes showed no change or gain in CDVA one year after LASIK. Torky MA et al [ 14 ] found that 88.2% of high myopic eyes got the SE within±0.50D by SMILE surgery six months postoperatively.…”

Phakic Posterior Chamber Intraocular Lens with a Central Hole in Treating Patients with Moderate to High Myopia: A Meta-Analysis

“…Refractive surgery methods for correcting myopia mainly include corneal refractive surgery and intraocular refractive surgery. For the surgical treatment of patients with moderate to high myopia, corneal refractive surgery, such as excimer laser and femtosecond laser, has certain limitations [4, 5]. Corneal refractive surgery has a large depth of corneal ablation, which changes the biomechanics of the cornea, while intraocular refractive surgery is a phakic posterior chamber intraocular lens (ICL) implantation technique that does not require cutting the cornea, which is relatively safer [6].…”