Twenty-four—hour variation in serum leptin in the elderly

Franceschini, R.; Corsini, G; Cataldi, A.; Fiorucci, Antonio Rogério; Tenerelli, Pasquale; Rolandi, E; Barreca, T

doi:10.1016/s0026-0495(99)90198-1

Cited by 20 publications

(14 citation statements)

References 22 publications

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“…Secondly, we chose animals of appropriately young ages for our control groups to compare with appropriately old-aged monkeys. In the Franceschini et al (1999) study, it is possible that more significant changes in the 24-h leptin rhythms would have been observed if the old group (72-87 years) would have been compared to a younger control group rather than middleaged men (35-50 years). Additionally, in the Zhao et al (2002) study, the men varied in age from 31 to 63 years.…”

Section: Discussionmentioning

confidence: 94%

“…In the previous studies, Franceschini et al (1999) and Zhao et al (2002) sought to identify aging-related changes in circulating 24-h leptin concentrations and found that there were minor changes in amplitude and overall mean levels respectively, but in both cases the 24-h leptin rhythm was generally preserved with old age. We were able to advance these previous observations in several ways.…”

Section: Discussionmentioning

confidence: 99%

“…Little is currently known about the effect of aging on the 24-h pattern of circulating leptin. However, moderate dampening of nocturnal leptin levels has been reported in old men, and with advancing age the acrophase of the leptin rhythm appears to occur earlier in the day (Franceschini et al 1999, Zhao et al 2002.…”

Section: Introductionmentioning

confidence: 97%

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Aging-related sex-dependent loss of the circulating leptin 24-h rhythm in the rhesus monkey

Downs

Urbanski

2006

Journal of Endocrinology

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The adipocyte-derived hormone leptin plays a pivotal role in the regulation of body weight and energy homeostasis. Many studies have indicated that the circulating levels of leptin show a 24-h rhythm, but the exact cause and nature of this rhythm is still unclear. In the present study, we remotely collected blood samples every hour from young and old, male and female rhesus monkeys, and examined their 24-h plasma leptin profiles. In both the young males (10-11 years) and females (7-13 years), a clear 24-h plasma leptin rhythm was evident with a peak occurring w4 h into the night and a nadir occurring w1 h into the day (lights on from 0700 to 1900 h). A 24-h plasma leptin rhythm was also observed in the old males (23-30 years), even when they were maintained under constant lighting conditions (continuous dim illumination of w100 lx). In marked contrast, plasma leptin concentrations were relatively constant across the day and night in old peri-and post-menopausal females (17-24 years), regardless of the lighting schedule. These data establish that rhesus monkeys, like humans, show a daily nocturnal rise in plasma leptin, and the magnitude of this rhythm undergoes a sex-specific aging-dependent attenuation. Furthermore, they suggest that the underlying endocrine mechanism may be driven in part by a circadian clock mechanism.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

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Aging-related sex-dependent loss of the circulating leptin 24-h rhythm in the rhesus monkey

Downs

Urbanski

2006

Journal of Endocrinology

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“…Diurnal variations in serum leptin levels have been documented in children (Wolthers et al, 1999) as well as in adults (Franceschini et al, 1999). Leptin levels were reported higher in the morning than in the evening and night.…”

Section: Discussionmentioning

confidence: 99%

Sexual dimorphism in relationship of serum leptin and relative weight for the standard in normal-weight, but not in overweight, children as well as adolescents

Nakanishi

Liu

et al. 2001

Eur J Clin Nutr

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Objective: To demonstrate sexual dimorphism in serum leptin levels not only during puberty, but also in childhood in Japan. Design: Cross-sectional study. Setting: Hamamatsu-Hokuen study in Japan. Subjects: Body weight and height were measured in normal-weight Japanese children and adolescents (143 boys, 178 girls), and 161 boys and 129 girls whose percentage of overweight for the standard (%Wt) was more than þ 25%. Serum leptin levels were compared with %Wt. Subjects were divided into group 1 (6 -10 y of age) and group 2 (11 -15 y of age) according to their age. Results: In overweight subjects, leptin was more highly correlated with %Wt in boys of group 2 (r ¼ 0.67, P < 0.0001) than group 1 (r ¼ 0.32, P ¼ 0.004). In girls as well, a correlation coefficient was greater in group 2 (r ¼ 0.67, P < 0.0001) than group 1 (r ¼ 0.44, P ¼ 0.0011). In normal-weight boys, there was no significant correlation between serum leptin and %Wt both in groups 1 and 2. On the contrary, statistical significance was demonstrated in the correlation between serum leptin and %Wt in group 1 (r ¼ 0.31, P ¼ 0.0019) and group 2 (r ¼ 0.35, P ¼ 0.0014) as well as in the total normal-weight girls (r ¼ 0.28, P ¼ 0.0011). Conclusions: It is suggested that sexual dimorphism is present in serum leptin levels, especially when compared to weight, as early as during childhood.

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“…Evidence for linkage increased when considering the smaller sample of African Americans only, and did not change substantially in the subsample that included only individuals with leptin levels drawn after the normal early morning peak in leptin secretion. 18 The peak on chromosome 4 can be viewed as a potential new peak, while the others are near candidate genes for various components of the metabolic syndrome.…”

Section: Discussionmentioning

confidence: 99%

Linkage of serum leptin levels in families with sleep apnea

et al. 2004

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OBJECTIVE:To identify regions on the genome linked to plasma leptin levels. DESIGN: Full genome scan with 402 microsatellite markers, spaced B10 cM apart. Data were analyzed using the HasemanElston regression linkage analysis. SUBJECTS: A total of 160 sibling pairs from 59 predominantly African American, obese families recruited to participate in a genetic-epidemiological study of obstructive sleep apnea. MEASUREMENTS: Serum leptin levels adjusted for age, sex, race and body mass index (BMI). RESULTS: Suggestive linkage peaks were observed on chromosomes 2 (P ¼ 0.00170; marker D2S1384), 3 (P ¼ 0.00007; marker D3S3034), 4 (P ¼ 0.00020; marker D4S1652) and 21 (P ¼ 0.00053; marker D21s1411). CONCLUSION: The peak on chromosome 3 is near the gene for glycogensynthase kinase 2 beta, an important factor in glucose homeostasis. Linkage was generally stronger after BMI adjustment, suggesting the potential influence of a number of metabolic pathways on leptin levels other than those that directly determine obesity levels. The evidence of linkage for leptin levels is consistent with prior linkage analyses for cholesterol, hypertension and other metabolic phenotypes.

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Twenty-four—hour variation in serum leptin in the elderly

Cited by 20 publications

References 22 publications

Aging-related sex-dependent loss of the circulating leptin 24-h rhythm in the rhesus monkey

Aging-related sex-dependent loss of the circulating leptin 24-h rhythm in the rhesus monkey

Sexual dimorphism in relationship of serum leptin and relative weight for the standard in normal-weight, but not in overweight, children as well as adolescents

Linkage of serum leptin levels in families with sleep apnea

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