Twice daily 4% Sodium Cromoglycate vs. 2% Sodium Cromoglycate used four times daily in seasonal (grass pollen) allergic conjunctivitis

Abstract

It is well established that 2% Sodium Cromoglycate is an effective treatment for a number of allergic eye diseases. It has been shown to be non-toxic. It can be used longterm and in serious allergic problems it is a useful adjunctive therapy to steroids. The main problem with Sodium Cromoglycate is that the recommended dosage is a four times daily application and patient non-compliance is common. One of the main objectives of any therapy is to reduce the frequency of dosage and the current study has been designed to investigate the efficacy of a 4% solution of Sodium Cromoglycate, used twice daily, versus a 2% solution used four times daily in seasonal allergic conjunctivitis. A multicentre study, therefore, was carried out to assess the efficacy of both drugs and to assess any possibility of side effects. In addition, a unit dose was used, thus eliminating preservatives and it was used specifically in seasonal allergic conjunctivitis in the pollen season. This study showed that 4% Sodium Cromoglycate used twice daily was at least as affective as 2% Sodium Cromoglycate used four times daily.

Safety and efficacy of sodium cromoglycate-fluorometholone fixed combination eye drops in allergic conjunctivitis

“…Sodium cromoglycate is a mast cell stabilizer that prevents type I allergic reactions, and therefore, it might alleviate the ocular signs and symptoms of acute and chronic allergic conjunctivitis, and vernal keratoconjunctivitis. [ 6 7 8 13 ] While fluorometholone is a steroid used to treat inflammation of the allergic and papillary conjunctivitis. [ 10 14 15 16 ] Sodium cromoglycate-fluorometholone eye drops are a combination of sodium cromoglycate (20 mg/ml) and fluorometholone (1 mg/ml) for the treatment of chronic allergic conjunctivitis and vernal keratoconjunctivitis.…”

“…[ 6 ] Sodium cromoglycate eye drops are widely prescribed for the treatment of allergic eye diseases and allergic rhinitis. [ 6 7 8 ] Fluorometholone is a steroid used to treat the eye inflammation. In a clinical study, the combination of fluorometholone and bromfenac sodium achieved an improvement in the ocular signs and symptoms and the global evaluation scale of patients with allergic conjunctivitis.…”