Twin concordances test for ascertained trichotomous traits data

Huang, Jason Kunming; Tai, John Jen

doi:10.1002/sim.2841

Cited by 2 publications

(9 citation statements)

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“…The standard error and 95% confidence interval were estimated according to methods documented by Huang and Tai. 18 The totals for concordant and discordant pairs have been pooled across the 25 individual betaPV types. One estimate was calculated for partner pairs and a second for the pairs formed by matched control couples.…”

Section: Methodsmentioning

confidence: 99%

Transmission of betapapillomaviruses between domestic partners in an Australian community

Plasmeijer

Green

Koning

et al. 2010

Journal of Clinical Virology

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Section: Methodsmentioning

confidence: 99%

Transmission of betapapillomaviruses between domestic partners in an Australian community

Plasmeijer

Green

Koning

et al. 2010

Journal of Clinical Virology

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“…In this paper, we apply the likelihood theory to the estimation of pair concordance for ascertained twin pair multinomial data. The ideas are related to the previous works in , which was expanded in . We establish the complete likelihood‐based testing procedures to test the equality of overall casewise concordances for ascertained twin pair multinomial data.…”

Section: Introductionmentioning

confidence: 96%

“…) or log‐linear models (e.g. ) and concordance measures (casewise or pairwise concordance) based on binomial or trinomial models .…”

Section: Introductionmentioning

confidence: 99%

“…) to analyze the ascertained twin pair continuous data with probands that have been selected because of deviant scores on a continuous variable. The frequently used similarity measures for analyzing the ascertained twin pair multinomial data are the casewise and pairwise concordances for ascertained twin pair binomial data , and the overall casewise concordance and overall pairwise concordance for ascertained twin pair trinomial data . Extending the analysis methods for the ascertained twin pair binomial data to those for the ascertained twin pair trinomial data is not so trivial.…”

Section: Introductionmentioning

confidence: 99%

“…Extending the analysis methods for the ascertained twin pair binomial data to those for the ascertained twin pair trinomial data is not so trivial. Huang and Tai used the self‐contained subdivision method (SCSM) to obtain the maximum likelihood estimates (MLEs) of the overall concordances and avoid the difficulty in the simultaneous estimation of the concordances, prevalences and ascertainment probabilities in a likelihood setting. The equivalence of an SCSM estimate to the MLE was proved by the invariance property of the MLE.…”

Section: Introductionmentioning

confidence: 99%

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Likelihood‐based concordance tests for analysis of ascertained twin pair multinomial data

Huang

Liu

Tai

2011

Statistics in Medicine

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The classic twin model design has a wide application in human genetics. Under the assumption that nongenetic effects are shared to the same degree by monozygotic (MZ) and dizygotic (DZ) twin pairs, a test of the equality of casewise concordances between MZ and DZ twins provides a clue to the influence of genetic and environmental factors on a disease. The casewise concordance is the conditional probability that given that one member of a twin pair is affected, the other is also affected. When disease prevalence is low or cost-effectiveness is considered, collection of twin pairs by ascertainment for performing casewise concordance analysis is required. In this article, by defining an overall casewise concordance parameter, several likelihood-based tests, such as likelihood ratio test LR, score test Score, the usual Wald test Wald and an alternative Wald test WaldA are investigated for a test of the equality of concordances between ascertained MZ and DZ twin pairs under multinomial models. Simulation studies were conducted for data with small sample sizes. The results show that the type I error rates and power of LR and Score are stable only when the overall casewise concordances are not extremely small or large. The Wald has higher power performance in most cases but would slightly inflate type I error rates; the WaldA is the most robust and recommended approach.

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Twin concordances test for ascertained trichotomous traits data

Cited by 2 publications

References 0 publications

Transmission of betapapillomaviruses between domestic partners in an Australian community

Transmission of betapapillomaviruses between domestic partners in an Australian community

Likelihood‐based concordance tests for analysis of ascertained twin pair multinomial data

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