Twin Pregnancy Consisting of 46, XY Heterozygous Complete Mole Coexisting with a Live Fetus

Kashimura, Y; Tanaka, Mari; Harada, Naoki; Shinmoto, Masahiro; Morishita, Tadashi; Morishita, Hideo; Kashimura, Masamichi

doi:10.1053/plac.2000.0613

Cited by 13 publications

(8 citation statements)

References 22 publications

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“…In pregnancies with a live fetus and partial mole, there is a very high incidence of abnormal karyotype (triploid) and congenital malformations of the fetus, 7 while CHM‐OCF is associated with a high risk of PTD 19 . In addition, it has been suggested that a heterozygous mole has a higher malignant potential, compared to a homozygous mole in pregnancies complicated by CHM irrespective of the presence of coexisting fetus 20,21 . Therefore, it is clinically important to discriminate CHM from partial mole, and heterozygous CHM from homozygous CHM, in the management of pregnant women with a live fetus/fetuses complicated by an intrauterine tumor with molar change.…”

Section: Discussionsupporting

confidence: 89%

“…Among 14 cases, zygosity was analyzed only in six cases. Although the number of cases is limited, the incidence of PTD in homozygous CHM (two out of four) and in heterozygous CHM (two out of two) is compatible with the previous observation in CHM‐OCF (two out of six in homozygous CHM and two out of three in heterozygous CHM) 21 . Since the currently available information is limited, detailed analysis of zygosity should be performed in cases of CHM‐TCF to establish optimized management for this extremely rare pregnancy complication.…”

Section: Discussionmentioning

confidence: 99%

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Complete hydatidiform mole in a triplet pregnancy coexisting two viable fetuses: Case report and review of the literature

Takagi

Unno

Hyodo

et al. 2003

J of Obstet and Gynaecol

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We report a rare case of a complete hydatidiform mole with two or more coexisting fetuses where both infants survived without complications. A male infant weighing 1258 g and a female infant weighing 880 g were delivered without complications and discharged 95 days after the birth. The analysis of DNA microsatellite polymorphisms indicated that the mole was of paternal origin and probably homozygous. The mother suffered from multiple pulmonary metastasis of the hydatidiform mole which was detected 3 days after the surgery and was successfully treated with methotrexate. A complete hydatidiform mole with two or more coexisting fetuses produces a dilemma between immediate termination and pregnancy continuation. Although the present case resulted in a favorable outcome, a review of the 14 reported cases suggests that the high fetal loss rate (90%) must be a consideration in the decision regarding management of such a pregnancy.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Complete hydatidiform mole in a triplet pregnancy coexisting two viable fetuses: Case report and review of the literature

Takagi

Unno

Hyodo

et al. 2003

J of Obstet and Gynaecol

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“…It is important to make the distinction because CHM has a greater propensity to develop into PTD, especially moles having many heterozygous alleles (4), (5). The incidence of PTD development from CMCF is not related to the gestational age at termination or delivery (1), (6). Analysis of CHM zygosity of villous obtained by transvaginal or transabdominal sampling in cases of CMCF may provide worthwhile information of the risk of PTD.…”

Section: Discussionmentioning

confidence: 99%

A triplet pregnancy featuring a 47, XY + 9 heterozygous complete mole coexisting with two fetuses at 9 weeks

Suzuki

Itakura

Ino

et al. 2007

Acta Obstet Gynecol Scand

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“…Twin pregnancy consisting of a complete hydatidiform mole and a coexisting viable fetus is rare, with a reported occurrence rate of 1/22,000 to 1/100,000. [1][2][3] Although the ultrasound diagnosis of coexisting mole has been reported previously, 2 a literature search using PubMed and search term ''coexisting mole'' from 1965 to the present indicates that the diagnosis of coexisting molar pregnancy after referral for abnormal serum screen has not been documented previously.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound Diagnosis of Coexisting Molar Pregnancy Following Referral for Abnormal Serum Screen

et al. 2005

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Complete hydatidiform mole and coexistent fetus is a rare occurrence. We report a case of a patient referred for abnormal serum screen and vaginal bleeding in the second trimester of pregnancy. Ultrasound revealed a cystic and solid mass along the posterior uterine wall with multiple hypoechoic (honeycomb) areas noted, consistent with molar degeneration of the placenta. Separate from this mass was a coexisting viable fetus with normal fetal anatomy and distinct anterior placenta. At delivery, a large cystic mass of placental tissue appeared to be implanted separately from a normal-appearing fetus and placenta. The mass weighed 184 g and contained multiple 1- to 1.5-cm cysts throughout. Microscopic sections revealed hydropic chorionic villi with central cistern formation and nonpolar trophoblastic hyperplasia with atypia, compatible with complete hydatidiform mole. This case illustrates that the diagnosis of coexisting molar pregnancy after referral for abnormal serum screen should be considered, especially if maternal serum beta-human chorionic gonadotropin is high and the patient has vaginal bleeding.

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Twin Pregnancy Consisting of 46, XY Heterozygous Complete Mole Coexisting with a Live Fetus

Cited by 13 publications

References 22 publications

Complete hydatidiform mole in a triplet pregnancy coexisting two viable fetuses: Case report and review of the literature

Complete hydatidiform mole in a triplet pregnancy coexisting two viable fetuses: Case report and review of the literature

A triplet pregnancy featuring a 47, XY + 9 heterozygous complete mole coexisting with two fetuses at 9 weeks

Ultrasound Diagnosis of Coexisting Molar Pregnancy Following Referral for Abnormal Serum Screen

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