Two axial-flow Synergy Micro-Pumps as a biventricular assist device in an ovine animal model

Schmitto, Jan D.; Burkhoff, Daniel; Avşar, M.; Fey, O.; Ziehme, P.; Buechler, Gwen; Haverich, Axel; Strueber, M.

doi:10.1016/j.healun.2012.08.008

Cited by 18 publications

(8 citation statements)

References 42 publications

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“…The Circulite Synergy device is another miniaturized hybrid axial-centrifugal-flow pump that has been evaluated in preclinical models for RV and biventricular support. [58][59][60][61]…”

Section: Durable Mcs Options For Rv Failurementioning

confidence: 99%

Mechanical Circulatory Support Devices for Acute Right Ventricular Failure

et al. 2017

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Right ventricular (RV) failure remains a major cause of global morbidity and mortality for patients with advanced heart failure, pulmonary hypertension, or acute myocardial infarction and after major cardiac surgery. Over the past 2 decades, percutaneously delivered acute mechanical circulatory support pumps specifically designed to support RV failure have been introduced into clinical practice. RV acute mechanical circulatory support now represents an important step in the management of RV failure and provides an opportunity to rapidly stabilize patients with cardiogenic shock involving the RV. As experience with RV devices grows, their role as mechanical therapies for RV failure will depend less on the technical ability to place the device and more on improved algorithms for identifying RV failure, patient monitoring, and weaning protocols for both isolated RV failure and biventricular failure. In this review, we discuss the pathophysiology of acute RV failure and both the mechanism of action and clinical data exploring the utility of existing RV acute mechanical circulatory support devices.

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“…The Circulite Synergy device is another miniaturized hybrid axial-centrifugal-flow pump that has been evaluated in preclinical models for RV and biventricular support. [58][59][60][61]…”

Section: Durable Mcs Options For Rv Failurementioning

confidence: 99%

Mechanical Circulatory Support Devices for Acute Right Ventricular Failure

et al. 2017

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“…20 In animal studies, two SYNERGY pumps have even been used as a biventricular assist device. 21 To our knowledge, however, the SYNERGY pump has not been used in conjunction with an oxygenator to provide pulmonary, as well as cardiac support. This application extends the use of the pump beyond that of a ventricular assist device to an ultraminiaturized ECMO circuit.…”

Section: Discussionmentioning

confidence: 99%

A Novel ECMO Circuit Using a SYNERGY Circulite Pump in a Swine Model

et al. 2014

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Extracorporeal membrane oxygenation (ECMO) is used in the management of refractory cardiopulmonary failure. With improvements in technology, patients can be transferred between hospitals, ambulated, and supported for extended periods of time while on ECMO. The SYNERGY CircuLite micropump is a blood pump that has been used as a ventricular assist device for partial support. In this study, we assessed the blood biocompatibility of the SYNERGY blood pump in conjunction with a Quadrox D oxygenator for use in a novel ECMO circuit in a swine model. This clinical design was used to demonstrate early feasibility of this pump system. Four pigs were placed on venovenous ECMO circuit, which consisted of a SYNERGY pump, Quadrox D oxygenator, and Cobe E Pack 3/8 inch tubing. All animals survived the 6 hour ECMO run without catastrophic biocompatibility issues. There was no statistically discernible change from baseline in hematologic parameters, including hemoglobin, plasma-free hemoglobin, total bilirubin, lactate dehydrogenase, D-dimer, fibrinogen, platelets, and P-selectin. We believe that this study serves as a proof of concept and basis for further studies using the SYNERGY pump as a component of ECMO systems.

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“…The total artificial pulsatile heart assist device with double chambers supplies an alternative. Previous studies also implemented the bi-ventricular support using two axial ventricular assist devices in animal models (20). The APL is designed as an ambulatory cardiopulmonary assist device for chronic use.…”

Section: Discussionmentioning

confidence: 99%

Right ventricular unloading and respiratory support with a wearable artificial pump-lung in an ovine model

Liu

Sánchez

Wei

et al. 2014

The Journal of Heart and Lung Transplantation

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Background Device availability of mechanical circulatory or respiratory support to the right heart has been limited. The purpose of this study was to investigate the effect of right heart unloading and respiratory support with a wearable integrated artificial pump-lung (APL). Methods The APL device was placed surgically between the right atrium and pulmonary artery in seven sheep. Anticoagulation was performed with heparin infusion. Its ability to unload the right ventricle (RV) was investigated by echocardiograms and right heart catheterization at different bypass flow rates. Hemodynamics and Echo data were evaluated. The device flow and gas transfer rates were also measured at different device speeds. Results Hemodynamics remained stable during APL support. There was no significant change in systemic blood pressure and cardiac index. Central venous pressure, RV pressure, RV end-diastolic dimension and RV ejection fraction were significant decreased when APL device flow rate approached 2 L/min. The linear regression showed significant correlative trends between the hemodynamic and cardiac indices and the device speed. The oxygen transfer rate increased with the device speed. The oxygen saturation from APL outlet was fully saturated (>95%) during the support. The impact of the APL support on blood elements (plasma free hemoglobin and platelet activation) was minimal. Conclusion The APL device support significantly unloaded the right ventricle with increasing device speed. The APL device provided stable hemodynamic and respiratory support in terms of blood flow and oxygen transfer. The right heart unloading performance of this wearable device need to be evaluated in the animal model with right heart failure for a long term support.

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Two axial-flow Synergy Micro-Pumps as a biventricular assist device in an ovine animal model

Cited by 18 publications

References 42 publications

Mechanical Circulatory Support Devices for Acute Right Ventricular Failure

Mechanical Circulatory Support Devices for Acute Right Ventricular Failure

A Novel ECMO Circuit Using a SYNERGY Circulite Pump in a Swine Model

Right ventricular unloading and respiratory support with a wearable artificial pump-lung in an ovine model

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