Two bioactive mono-tetrahydrofuran acetogenins, annoglacins A and B, from Annona glabra

Liu, Xiaoxi; Alali, Feras Q.; Pilarinou, Elsa; McLaughlin, Jerry L.

doi:10.1016/s0031-9422(98)00466-x

Cited by 36 publications

(17 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The major constituents identified in the members of the Annonaceae are, typically, acetogenins (Zeng et al 1996;Liu et al 1999;Bermejo et al 2005) that exhibited in vitro antimalarial activities (Rakotomanga et al 2004), which could explain the antiplasmodial activity observed for Annona crassiflora, and the other Annonaceae like Duguetia furfuracea and Xylopia emarginata (de Mesquita et al 2007). The roots extract of Annona senegalensis showed activity against the chloroquinoresistant strain of P. falciparum (Fall et al 2003).…”

Section: Introductionmentioning

confidence: 99%

In vitro antimalarial activity of medicinal plant extracts against Plasmodium falciparum

Bagavan¹,

Rahuman²,

Kaushik

et al. 2010

Parasitol Res

125

View full text Add to dashboard Cite

Malaria is a major global public health problem, and the alarming spread of drug resistance and limited number of effective drugs now available underline how important it is to discover new antimalarial compounds. In the present study, ten plants were extracted with ethyl acetate and methanol and tested for their antimalarial activity against chloroquine (CQ)-sensitive (3D7) and CQ-resistant (Dd2 and INDO) strains of Plasmodium falciparum in culture using the fluorescence-based SYBR Green assay. Plant extracts showed moderate to good antiparasitic effects. Promising antiplasmodial activity was found in the extracts from two plants, Phyllanthus emblica leaf 50% inhibitory concentration (IC₅₀) 3D7: 7.25 μg/mL (ethyl acetate extract), 3.125 μg/mL (methanol extract), and Syzygium aromaticum flower bud, IC₅₀ 3D7:13 μg/mL, (ethyl acetate extract) and 6.25 μg/mL (methanol extract). Moderate activity (30-75 μg/mL) was found in the ethyl acetate and methanol extracts of Abrus precatorius (seed) and Gloriosa superba (leaf); leaf ethyl acetate extracts of Annona squamosa and flower of Musa paradisiaca. The above mentioned plant extracts were also found to be active against CQ-resistant strains (Dd2 and INDO). Cytotoxicity study with P. emblica leaf and S. aromaticum flower bud, extracts showed good therapeutic indices. These results demonstrate that leaf ethyl acetate and methanol extracts of P. emblica and flower bud extract of S. aromaticum may serve as antimalarial agents even in their crude form. The isolation of compounds from P. emblica and S. aromaticum seems to be of special interest for further antimalarial studies.

show abstract

Section: Introductionmentioning

confidence: 99%

In vitro antimalarial activity of medicinal plant extracts against Plasmodium falciparum

Bagavan¹,

Rahuman²,

Kaushik

et al. 2010

Parasitol Res

125

View full text Add to dashboard Cite

show abstract

“…都为 th/t/th, 唯一的不同之处也在于前者比后者的末端碳链上碳数少 2 个, 在比较这四个化合物的药效数据, [34] , glacin-A [35] 和 annoglacin-B [26] , goniothalamicin [14] 和 goniotetracin [36] , annocherimolin [37] 和 montalicin-E [14] . 符合本综述要求的化合物为 55 个(见表 1).…”

Section: 邻位双四氢呋喃型 Thf 两侧各有一个羟基相邻的相对构型有 Th/t/th/t/th Eunclassified

Progress in Structure Activity Relationship of Natural Annonaceous Acetogenins

Chen¹,

Li²,

Chen³

2012

Chin. J. Org. Chem.

View full text Add to dashboard Cite

show abstract

“…The whole plant is used in traditional medicine as an anticancer drug (Cochrane et al, 2008). Phytochemical investigation of this plant led to the isolation of acetogenins (Liu et al, 1999), ent-kauranes (Chen et al, 2000(Chen et al, , 2004, peptides (Li et al, 1999), and alkaloids (Likhitwitayawuid et al, 1993;Tsai & Lee, 2010). In addition, they exhibited anticancer (Chen et al, 2004), anti-HIV-reserve (Chang et al, 1998), and antimalaria activities (Likhitwitayawuid et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Chemical constituents of theAnnona glabrafruit and their cytotoxic activity

Hiền

Nhiệm

Yến

et al. 2015

Pharmaceutical Biology

View full text Add to dashboard Cite

Context: Traditional Chinese medicines have attracted increasing interest as potential sources of novel drugs with a wide range of biological and pharmacological activities. Annona glabra Linn (Annonaceae) is used in traditional medicine as an anticancer drug. Phytochemical investigation of this plant led to the isolation of acetogenins, ent-kauranes, peptides, and alkaloids. In addition, compounds exhibited anticancer, anti-HIV-reserve, and antimalaria. Objective: Isolation, structure determination, and cytotoxic activity evaluation of compounds from the methanol extract from A. glabra fruits. Materials and methods: Using chromatographic methods to isolate compounds from the A. glabra methanol extract. The cytotoxic activity of compounds was evaluated by a 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay. In addition, compounds which showed significant cytotoxic activity were chosen for further study apoptosis characteristics. (5), 3,4-dihydroxybenzoic acid (6), blumenol A (7), cucumegastigmane I (8), and icariside B 1 (9), were isolated from the fruits of A. glabra. Icariside D 2 (3) was found to show significant cytotoxic activity on the HL-60 cell line with the IC 50 value of 9.0 ± 1.0 mM and did not show cytotoxic activity on the Hel-299 normal cell line. The further test indicated that compound 3 induced apoptosis via alteration of expression of apoptosis-related proteins and decreased phosphorylation of AKT in HL-60 cells. Discussion and conclusion: The results suggested that the constituents from A. glabra may contain effective compounds which can be used as anticancer agents.

show abstract

Two bioactive mono-tetrahydrofuran acetogenins, annoglacins A and B, from Annona glabra

Cited by 36 publications

References 25 publications

In vitro antimalarial activity of medicinal plant extracts against Plasmodium falciparum

In vitro antimalarial activity of medicinal plant extracts against Plasmodium falciparum

Progress in Structure Activity Relationship of Natural Annonaceous Acetogenins

Chemical constituents of theAnnona glabrafruit and their cytotoxic activity

Contact Info

Product

Resources

About