Two cases of malignant lymphoma complicated by hemophagocytosis resembling orbital cellulitis

Nakajima, Ako; Abe, Tohru; Takagi, Takeshi; Satoh, Naoki; Sakuragi, Shozo; Miura, Ikuo; Wakui, Hideki; Oshima, Atushi; Horiuchi, Takahiro; Ono, Satoshi; Miura, Akira B.

doi:10.1016/s0021-5155(97)00036-1

Cited by 6 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most ocular adnexal lymphoproliferative lesions are known to have a B‐cell phenotype, 5 and usually present with exophthalmus, ptosis, swelling of eyelids and tumorous lesions. T‐cell lymphoma primarily involving the eyelid is very rare: 6 –8 only two patients having restricted eyelid lesions as an initial symptom were found to progress to systemic lymphoma 8 . These patients had the complication of haemophagocytic syndrome in the terminal stage, as in our patient 1.…”

mentioning

confidence: 56%

Epstein-Barr virus-associated lymphoid hyperplasia of the eyelid characterized by intramuscular infiltration

Ohtsuka

Iwatsuki

Kaneko

et al. 1999

British Journal of Dermatology

View full text Add to dashboard Cite

mentioning

confidence: 56%

Epstein-Barr virus-associated lymphoid hyperplasia of the eyelid characterized by intramuscular infiltration

Ohtsuka

Iwatsuki

Kaneko

et al. 1999

British Journal of Dermatology

View full text Add to dashboard Cite

“…Lymphoma of orbit can masquerade as orbital cellulitis [14][15][16][17]. The pathophysiology behind orbital lymphoma presenting as orbital cellulitis can be due to direct tumor invasion responsible for inflammation of orbital soft tissues [17].…”

Section: Discussionmentioning

confidence: 99%

Orbital Lymphoma Masquerading as Orbital Cellulitis

Chaurasiya

Agrawal

Chaudhary

et al. 2021

Case Reports in Ophthalmological Medicine

View full text Add to dashboard Cite

Background. Orbital lymphomas are primarily non-Hodgkin type and can originate from the eyelids, extraocular muscles, soft tissue orbital adnexa, conjunctiva, or lacrimal glands. Orbital malignancies often represent a diagnostic dilemma for clinicians given their varying and atypical presentations. Objective. To report a case of orbital lymphoma mimicking orbital cellulitis. Case. A 66-year-old male patient presented with sudden onset of painful proptosis with visual impairment in the left eye for 15 days. On ocular examination, best-corrected visual acuity was 6/12 in the right eye and 2/60 in the left eye, abaxial proptosis with hypertropia, swollen and erythematous eyelids, restricted extraocular movement in all cardinal position of gaze, conjunctival congestion with chemosis and tortuous vessels, sluggish pupillary reaction, and chorioretinal folds in the inferior quadrants. The case was diagnosed as left eye orbital cellulitis, and the patient was treated with broad-spectrum intravenous antibiotics and oral steroids. No clinically discernible response was noted despite 7 days of antibiotics and steroids. Contrast-enhanced computed tomography (CECT) orbit showed features suggestive of orbital lymphoma involving the ipsilateral maxillary and ethmoid sinuses. ENT consultation with diagnostic nasal endoscopy and biopsy was done. Histopathological reports showed features of non-Hodgkin lymphoma. Conclusion. Orbital malignancies masquerading as orbital cellulitis can pose a diagnostic dilemma. A multidisciplinary approach involving ENT consultation, radiological investigation, and pathological sampling can help achieve a timely diagnosis and appropriate management.

show abstract

“…Orbital cellulitis as the primary clinical appearance of a lymphoma has been reported in the literature before [ 11 , 12 ]. The diagnosis of a plasmablastic lymphoma with regard to this is, however, unique.…”

Section: Discussionmentioning

confidence: 99%

Plasmablastic lymphoma mimicking orbital cellulitis

Barkhuysen

Merkx

Weijs

et al. 2008

Oral Maxillofac Surg

View full text Add to dashboard Cite

Introduction Orbital cellulitis is an uncommon, potentially devastating condition that, when not promptly and adequately treated, can lead to serious sequelae. The presenting clinical signs are proptosis, swelling, ophthalmoplegia, pain and redness of the peri-orbital tissues. A number of cases have been reported in which these symptoms have been mistakenly interpreted as being secondary to an orbital infection whilst, in fact, other pathology was present. Discussion We add another case in which, on clinical grounds and after radiological assessment and laboratory tests, a working diagnosis of orbital cellulitis of the left eye was made. It was only after histopathological analysis of a soft tissue specimen from the maxillary sinus that a diagnosis of an AIDS-related plasmablastic lymphoma was made. The patient was referred to the department of haematology where chemotherapeutic treatment for the lymphoma and the HIV infection was started. This case report adds another differential diagnosis of orbital cellulitis to the existing literature.

show abstract

Two cases of malignant lymphoma complicated by hemophagocytosis resembling orbital cellulitis

Cited by 6 publications

References 8 publications

Epstein-Barr virus-associated lymphoid hyperplasia of the eyelid characterized by intramuscular infiltration

Epstein-Barr virus-associated lymphoid hyperplasia of the eyelid characterized by intramuscular infiltration

Orbital Lymphoma Masquerading as Orbital Cellulitis

Plasmablastic lymphoma mimicking orbital cellulitis

Contact Info

Product

Resources

About