Two cases of plasmacytoma in the oral cavity

Yoshimura, Yasuro; Takada, Kazuaki; Kawai, Naohiko; Hasegawa, Kiyoshi; Ishikawa, Takenori; Kawakatsu, Kensaku

doi:10.1016/s0300-9785(76)80052-x

Cited by 12 publications

(8 citation statements)

References 21 publications

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“…The majority of the studies reported bone lesions represented by plasmacytomas, but there were reports of “punched-out” lesions in seven cases. 1 , 5 , 9 , 11 , 16 , 19 The bone lesions were more frequently reported in the mandible than in the maxilla, even though there is less hematopoietic bone marrow in the mandible. 1 These lesions were associated to bone pain in almost half of the reported cases.…”

Section: Discussionmentioning

confidence: 99%

“…Most of the reported bone lesions were associated to clinical sweeling, 1 , 8 , 9 , 12 , 13 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 31 , 32 , 33 , 34 which may be explained by tumor expansion with neoplastic plasma cell activity in the bone. 15 It may be assumed that swelling is a late stage of jaw lesions, after the tumor has expanded.…”

Section: Discussionmentioning

confidence: 99%

“… 4 Commonly, bone lesions may be represented by diffuse or localized osteolytic lesions, named plasmacytomas, or by a ‘punched-out’ pattern. 1 The maxillary and mandibular bones may be affected by these lesions, 1 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 and nearly 35% of patients diagnosed with symptomatic MM present lesions in the jaws. 28 …”

Section: Introductionmentioning

confidence: 99%

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Can dentists detect multiple myeloma through oral manifestations?

Almeida

Cavalcanti

Freitas

et al. 2018

Hematology, Transfusion and Cell Therapy

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ObjectiveTo review published data on oral manifestations of multiple myeloma.MethodsAn electronic database search was performed of articles published from 1971 to November 2016 in order to identify studies that reported oral manifestations of patients with multiple myeloma. Case reports and case series with oral manifestations of multiple myeloma in English were included in the study. An additional search was performed of the references of the selected articles.ResultsThirty-seven articles that reported 81 patients with oral manifestations of multiple myeloma were selected: 30 case reports (82%) and seven case series (18%). The most common clinical features in the dental cavity were swelling (65.4%), bone pain (33.3%), paresthesia (27.1%) and amyloidosis lesions (11.1%). Osteolytic lesions detected on imaging exams were reported in the majority of the patients (90.1%) as plasmacytomas or ‘punched-out’ lesions.ConclusionsSwelling and osteolytic lesions represent the most common clinical and radiographic signs of the jaws relating to multiple myeloma, respectively.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Can dentists detect multiple myeloma through oral manifestations?

Almeida

Cavalcanti

Freitas

et al. 2018

Hematology, Transfusion and Cell Therapy

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“…This clinical condition coupled with the absence of bone pain symptoms lead the medical team delay to begin bisphosphonates treatment. Unfortunately, the patient died, which explains why the use 13 01 Mandible: swelling and osteolytic lesion of bisphosphonates was not applied earlier to prevent bone loss and fractures.…”

Section: Discussionmentioning

confidence: 99%

Multiple myeloma with primary manifestation in mandibular area

et al. 2011

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Multiple myeloma (MM) is a haematological disease characterised by the multicentric proliferation of plasma cells in the bone marrow. This relatively rare disease develops mainly in men (mean age, 60 years). The occurrence of the disease in jaws is uncommon as a primary manifestation. A 73‐year‐old man was first seen with a chief complaint of a painful mandibular enlargement persisting for 1 month with an increase in the volume of the gingiva, which bled during oral hygiene. The Xray revealed a ‘punched‐out’ lesion with ill‐defined margins in the mandibular ramus and body. A computed tomography scan showed a mandibular osteolytic lesion extending to the surrounding soft tissue. The incisional biopsy revealed a monotonous proliferation of plasmacytoid cells strongly immunoreactive to Kappa IgG, which confirmed the diagnosis of MM. After the biopsy, the patient spontaneously fractured his ribs, and the Bence Jones protein test was positive. Conformal radiotherapy followed by bortezomib with melphalan and prednisone was the elected treatment. The patient stopped treatment after two cycles, and progression to death followed after 6 months. This case report reinforces the data on the importance of early diagnosis of MM in the jaw and illustrates the contribution that oral assessment can provide for the diagnosis of this disease.

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“…In our opinion it is extremely needed to report about lesser-known diseases occurring possibly in the orofacial region. In earlier as well as recent literature only few articles exist dealing with case reports of plasmocytoma (2,3,9), mostly of the extramedullary type in soft tissue emphasizing the clinical manifestation (4,5) or rare combination with other malignancies (6). Epidemiologic evidence of the outcomes based on literature study is still controversial although radical surgery in combination with postoperative irradiation and chemotherapy provides acceptable results (7,8,4).…”

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confidence: 99%

Letter to the Editor

Stanko¹,

Sobolikova²,

Manesh³

et al. 2017

BLL

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Dear Editor-in-Chief, As practising specialists in the fi elds of oral medicine and maxillofacial surgery we would like to comment on the article published in issue 7/2016 of Bratislava Medical Journal from Zajko J et al (1). In our opinion it is extremely needed to report about lesser-known diseases occurring possibly in the orofacial region. In earlier as well as recent literature only few articles exist dealing with case reports of plasmocytoma (2, 3, 9), mostly of the extramedullary type in soft tissue emphasizing the clinical manifestation (4, 5) or rare combination with other malignancies (6). Epidemiologic evidence of the outcomes based on literature study is still controversial although radical surgery in combination with postoperative irradiation and chemotherapy provides acceptable results (7, 8,4).The authors stated that researchers still do not know exactly the causes of plasmocytoma but there are some factors that could be contributing to this disease. We would like to know whether the authors have noticed any factors of probable combination of factors in their cases? As this is a very rare condition with incidence of 3-4 per 100,000 inhabitants, would it not be even better to include the data from other specialists to create a larger study group for the analysis? The article reveals that all the patients were diagnosed at presentation with tumour-like lesions and had biochemically negative examinations. We would appreciate greatly any advice as e.g. on clinical symptomatology or radiological differential diagnosis that could enable general dentists to state an earlier diagnosis of plasmocytoma in the oral cavity.Despite our questions we would like to express our acknowledgement of the article and reported case with solitary plasmocytoma in the TMJ region. To our best knowledge, this is the fi rst case reported in this specifi c location.

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Two cases of plasmacytoma in the oral cavity

Cited by 12 publications

References 21 publications

Can dentists detect multiple myeloma through oral manifestations?

Can dentists detect multiple myeloma through oral manifestations?

Multiple myeloma with primary manifestation in mandibular area

Letter to the Editor

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