Two Cases of Pseudoaldosteronism (Liddle's Syndrome) in Siblings

Ohno, Fumitoshi; Harada, Hideo; Komatsu, K; Saijo, Kazuo; Miyoshi, Kazuo

doi:10.1507/endocrj1954.22.163

Cited by 5 publications

(3 citation statements)

References 2 publications

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“…Although no inheritability of the syndrome has been conoccurrence of Liddle's syndrome have been reported (Aaskog et al, 1967;Helbock and Reynolds, 1970;Hyman et al, 1979;Wang et al, 1981;Sakamoto et al, 1981;Rodriguez et el., 1981). However, all but one of the cases showed subnormal plasma aldosterone levels (Ohno et al, 1975). In the present female patient, PAC was not always low, and ranged between normal limits.…”

Section: Effect Of Spironolactonecontrasting

confidence: 44%

“…Since the time of Liddle's original report, similar cases have been described (Aaskog et al, 1967;Milora et al, 1967;Bravo et al, 1970;Helbock and Reynolds, 1970;Ohno et al, 1975;Hyman et al, 1979;Wang et al, 1981;Sakamoto et al, 1981;Rodriquez et al, 1981). Although no inheritability of the syndrome has been conoccurrence of Liddle's syndrome have been reported (Aaskog et al, 1967;Helbock and Reynolds, 1970;Hyman et al, 1979;Wang et al, 1981;Sakamoto et al, 1981;Rodriguez et el., 1981).…”

Section: Effect Of Spironolactonementioning

confidence: 73%

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Plasma Aldosterone Level in a Female Case of Pseudohyperaldosteronism (Liddle's Syndrome).

et al. 1989

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A 22-yr-old female suffering from hypertension, hypokalemic alkalosis and suppressed plasma renin activity was studied. The plasma aldosterone concentration (PAC) ranged between subnormal and normal levels while the other adrenal mineralocorticoids were normal. Examinations through computed. tomography and ultrasonography showed no abnormal findings. For diferential diagnosis, dexamethasone, spironolactone and triamterene were administered. Triamterene alone corrected the abnormalities in this case, and the therapeutic effect was further enhanced by sodium restriction.

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Section: Effect Of Spironolactonecontrasting

confidence: 44%

Section: Effect Of Spironolactonementioning

confidence: 73%

Plasma Aldosterone Level in a Female Case of Pseudohyperaldosteronism (Liddle's Syndrome).

et al. 1989

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“…The degree of hypertension is variable within kindreds and some members of families with the disorder have normal BP. The pedigree described by Liddle was Caucasian but there have been additional descriptions of Japanese families with the syndrome (250,370), in a Hispanic family (292) and in an African American kindred (102).…”

Section: Pseudoaldosteronism Liddle's Syndromementioning

confidence: 99%

Pathophysiology, Diagnosis, and Treatment of Mineralocorticoid Disorders

Magill

2014

Comprehensive Physiology

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The renin-angiotensin-aldosterone system (RAAS) is a major regulator of blood pressure control, fluid, and electrolyte balance in humans. Chronic activation of mineralocorticoid production leads to dysregulation of the cardiovascular system and to hypertension. The key mineralocorticoid is aldosterone. Hyperaldosteronism causes sodium and fluid retention in the kidney. Combined with the actions of angiotensin II, chronic elevation in aldosterone leads to detrimental effects in the vasculature, heart, and brain. The adverse effects of excess aldosterone are heavily dependent on increased dietary salt intake as has been demonstrated in animal models and in humans. Hypertension develops due to complex genetic influences combined with environmental factors. In the last two decades, primary aldosteronism has been found to occur in 5% to 13% of subjects with hypertension. In addition, patients with hyperaldosteronism have more end organ manifestations such as left ventricular hypertrophy and have significant cardiovascular complications including higher rates of heart failure and atrial fibrillation compared to similarly matched patients with essential hypertension. The pathophysiology, diagnosis, and treatment of primary aldosteronism will be extensively reviewed. There are many pitfalls in the diagnosis and confirmation of the disorder that will be discussed. Other rare forms of hyper- and hypo-aldosteronism and unusual disorders of hypertension will also be reviewed in this article.

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Chapter 19 The Involvement of Amiloride-Sensitive Na+ Channels in Human Genetic Hypertension: Liddle's Syndrome

Benos

1999

Current Topics in Membranes

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Two Cases of Pseudoaldosteronism (Liddle's Syndrome) in Siblings

Cited by 5 publications

References 2 publications

Plasma Aldosterone Level in a Female Case of Pseudohyperaldosteronism (Liddle's Syndrome).

Plasma Aldosterone Level in a Female Case of Pseudohyperaldosteronism (Liddle's Syndrome).

Pathophysiology, Diagnosis, and Treatment of Mineralocorticoid Disorders

Chapter 19 The Involvement of Amiloride-Sensitive Na+ Channels in Human Genetic Hypertension: Liddle's Syndrome

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