Two cases of renal hypouricemia in which dopamine infusion produced a good recovery from exercise-induced acute kidney injury

Saito, Osamu; Sugase, Taro; Saito, Tomoaki; Akimoto, Tetsu; Ando, Yosuke; Muto, Satoru; Kusano, Emiko

doi:10.5414/cn106919

Cited by 4 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Considering these results and the developmental mechanism of EIAKI (i.e., ROS and renal ischemia), we suspect that the vasopressors may have affected the onset or worsening of EIAKI by increasing ROS, exacerbating vasoconstriction, and forming a vicious cycle of diminished renal hemodynamics. Karasawa et al [15] reported a case of EIAKI who was given midodrine, another vasopressor, before the onset of EIAKI, and Saito et al [16] described that vasoexpansion by low-dose dopamine improved the resistance index of renal arterioles in 2 cases of EIAKI, implying the relation between vasopressors and EIAKI in clinical settings. Although no studies have directly addressed the relationship between vasopressors and EIAKI, past reports and our own results indicate an importance of catecholamine level homeostasis in the pathogenesis of EIAKI.…”

Section: Discussionmentioning

confidence: 99%

A Case of Acute Kidney Injury in a Patient with Renal Hypouricemia without Intense Exercise

Aomura

Sonoda

Harada

et al. 2020

Case Rep Nephrol Dial

View full text Add to dashboard Cite

KeywordsExercise-induced acute kidney injury · Renal hypouricemia · Vasopressor AbstractExercise-induced acute kidney injury (EIAKI) frequently develops in patients with renal hypouricemia (RHUC). However, several cases of RHUC with acute kidney injury (AKI) but without intense exercise have been reported. We encountered a 15-year-old male with RHUC who experienced AKI. He reported no episodes of intense exercise and displayed no other representative risk factors of EIAKI, although a vasopressor had been administered for orthostatic dysregulation before AKI onset. His kidney dysfunction improved with discontinuation of the vasopressor and conservative treatment. Thus, AKI can develop in patients with RHUC in the absence of intense exercise, for which vasopressors may be a risk factor.

show abstract

Section: Discussionmentioning

confidence: 99%

A Case of Acute Kidney Injury in a Patient with Renal Hypouricemia without Intense Exercise

Aomura

Sonoda

Harada

et al. 2020

Case Rep Nephrol Dial

View full text Add to dashboard Cite

show abstract

“…For example, several authors oppose the use of dopamine in the ICU for the prevention and treatment of AKI (Kolesnik et al 2010, Kellum and Decer 2001, KDIGO 2012, Lauschke et al 2006. Others evaluate positively the experience of using this drug, especially in prerenal AKI (Bellomo et al 2000, Saito et al 2011. At the same time, it has been proposed to use erythropoietin and iron to correct anemia.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological correction of intrarenal hemodynamic disorders in acute kidney injury (part 2)

Gorodnik¹,

Шано²,

Кузнецова³

et al. 2018

RRP

View full text Add to dashboard Cite

Introduction: Treatment of acute kidney injury (AKI) is a complex current problem. Mortality in this pathology is over 50%. One of the areas of correction therapy in AKI patients is the improvement of diagnostics and the earliest identification of the underlying cause of AKI. The second promising direction in reducing mortality is prevention of AKI progression (nephroprotection) and resulting multi-organ disorders by individual pharmacological and non-pharmacological intensive therapy.Objectives: to evaluate the possibilities of individual pharmacological correction and intensive care of patients with AKI of different origin. Materials and methods:A prospective nonrandomized study. Inclusion criteria: patients with prerenal, renal and subrenal AKI module in stage of oligoanuria and restoration of diuresis. Exclusion criteria: AKI in patients after cardiosurgery and operations on large vessels. Individual pharmacological and non-pharmacological correction (renoprotection) was performed in 250 ICU patients with prerenal (130), renal (81) and subrenal (39) AKI. The effectiveness of individual nephroprotection was assessed by the duration of the oligoanuria stage (indicator of AKI severity). Results and discussion:The basis of intensive therapy in AKI patients was renal replacement therapy and peridialysis care. Peridialisys support was presented by a complex of therapeutic measures aimed at preventing the progression of AKI (nephroprotection) and the prevention of multi-organ complications. Individual pharmacological and non-pharmacological peridialysis intensive therapy was performed, including: removal of the main cause of forming AKI; maintenance of normal circulation blood volume and effective cardiac output; maintenance of adequate lung ventilation (correction of hypoxia, timely ventilation); correction of hypertension, hypotension, and clinically significant arrhythmia; improvement of renal blood flow and stimulation of diuresis; stopping bleeding and correction of anemia; targeted antibiotic therapy; removal or adequate drainage of the intoxication focus (purulent focus); use of alternative ways of detoxication and efferent methods. It was proved that individual pharmacological and non-pharmacological nephroprotection made it possible to improve the results of treatment. The duration of the oligoanuria stage significantly (p < 0.05) decreased to 14.3±0.9 days in the main group (22.6±1.2 days in the comparison group). Conclusions:The medical technology of individual intensive therapy with renal replacement therapy and peridialysis care has been developed, including: a diagnostic stage with determination of peculiarities of renal hemodynamic disorders and pharmacological and instrumental (stenting, drainage, etc.) correction of the real cause and manifestations of AKI. Improving AKI diagnostics and carrying out individual pharmacological and non-pharmacological correction improves the results of AKI treatment. Copyright Shramenko KK et al. This is an open access article distributed under the terms of the Creati...

show abstract

“…However, subjects with renal hypouricaemia (a condition where the plasma antioxidant uric acid is low) frequently develop exercise‐induced AKI (Ishikawa, 2002; Yan et al . 2010; Saito et al . 2011).…”

Section: Introductionmentioning

confidence: 99%

“…Exercise-associated AKI is usually rare and associated with high-intensity exercise such as marathon running (Clarkson, 2007). However, subjects with renal hypouricaemia (a condition where the plasma antioxidant uric acid is low) frequently develop exercise-induced AKI (Ishikawa, 2002;Yan et al 2010;Saito et al 2011). Together, these studies suggest that in vulnerable individuals, exercise may increase susceptibility to an oxidative stress-mediated insult such as ischaemia-reperfusion (IR)-induced AKI, possibly connected to reduced renal eNOS/EC SOD.…”

Section: Introductionmentioning

confidence: 99%

Effects of voluntary wheel running on the kidney at baseline and after ischaemia–reperfusion‐induced acute kidney injury: a strain difference comparison

Moningka¹,

Cunningham²,

Sterling³

et al. 2013

The Journal of Physiology

View full text Add to dashboard Cite

Exercise-induced vascular endothelial adaptations in the kidney are not well understood. Therefore, we investigated the impact of voluntary wheel running (VWR) on the abundance of endothelial nitric oxide synthase (eNOS) and extracellular superoxide dismutase (EC SOD), in kidney and lung, and other SOD isoforms and total antioxidant capacity (TAC), in kidney. We also determined whether VWR influences susceptibility to acute kidney injury (AKI). Male Sprague-Dawley and Fisher 344 rats, VWR or sedentary for 12 weeks, were subjected to AKI (uninephrectomy (UNX) and 35 min of left kidney ischaemia-24 h reperfusion, IR). We measured glomerular filtration rate (GFR) and renal plasma flow (RPF), and analysed renal structural injury. Running was comparable between strains and VWR reduced body weight. In Sprague-Dawley rats, VWR reduced eNOS and EC SOD, but increased Mn SOD in kidney. Similar changes were seen after 6 weeks of VWR in Sprague-Dawley rats. In Fisher 344 rats, VWR increased eNOS, all SOD isoforms and TAC in kidney. Both strains increased eNOS and EC SOD in lung with VWR. Compared to UNX alone, UNX-IR injury markedly reduced renal function for both strains; however, in the Sprague-Dawley rats, VWR exacerbated falls in GFR and RPF due to UNX-IR, whereas in the Fisher 344 rats, GFR was unaffected by VWR. Some indices of renal structural injury due to UNX-IR tended to be worse in SD vs. F344. Our study demonstrates that genetic background influences the effect of exercise on kidney eNOS and EC SOD, which in turn influence the susceptibility to AKI.

show abstract

Two cases of renal hypouricemia in which dopamine infusion produced a good recovery from exercise-induced acute kidney injury

Cited by 4 publications

References 0 publications

A Case of Acute Kidney Injury in a Patient with Renal Hypouricemia without Intense Exercise

A Case of Acute Kidney Injury in a Patient with Renal Hypouricemia without Intense Exercise

Pharmacological correction of intrarenal hemodynamic disorders in acute kidney injury (part 2)

Effects of voluntary wheel running on the kidney at baseline and after ischaemia–reperfusion‐induced acute kidney injury: a strain difference comparison

Contact Info

Product

Resources

About