Two Cases of Severe Neonatal Dengue Fever During an Outbreak in Kolkata City

Abstract

Indian J Case Reports 120 Ghosh et al. Two cases of neonatal dengue

Unusual presentation of dengue haemorrhagic fever in a neonate: Fluid leak and shock on day 1 of illness

“…Newborn with DF may remain asymptomatic 9 . Fever, thrombocytopenia, hepatomegaly, elevated transaminases, DHF and DSS have been reported in the literature 2,6,8,10 . In severely affected babies, bleeding manifestations, including cerebral haemorrhages, can occur 3,11 .…”

“…In severely affected babies, bleeding manifestations, including cerebral haemorrhages, can occur 3,11 . Though perinatal transmission of DF is being reported more frequently from different regions, no consensus has been reached regarding management of neonatal dengue 10 . Fever onset in newborns ranges from 1 to 11 days after birth with a mean of 4 days and may last for 1-5 days 6,12 .…”

“…Confirmation of dengue infection can be made by virus isolation, detection of viral RNA by polymerase chain reaction (PCR) and NS1 antigen 7,8 . Samples should be taken for dengue viral detection within the first four to five days during the febrile phase 7,10 . IgM levels can be detected from 3-5 days, peak around two weeks, and decline to undetectable levels by 2-3 months 7,10 .…”

“…Samples should be taken for dengue viral detection within the first four to five days during the febrile phase 7,10 . IgM levels can be detected from 3-5 days, peak around two weeks, and decline to undetectable levels by 2-3 months 7,10 . IgG appears in low levels in the beginning after IgM 7,10 .…”

“…IgM levels can be detected from 3-5 days, peak around two weeks, and decline to undetectable levels by 2-3 months 7,10 . IgG appears in low levels in the beginning after IgM 7,10 . Blood PCR aids identification of the dengue serotype 2 .…”