Two cases of transient pseudohypoaldosteronism due to group B streptococcus pyelonephritis

Kashimada, Kenichi; Omori, Tae; Takizawa, Fumihiko; Mizutani, Shuki

doi:10.1007/s00467-008-0843-9

Cited by 8 publications

(6 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because, in CAH and PHA1, the electrolyte inbalances are identical, some patients with THPA1, especially those who are severely ill, are incorrectly diagnosed as having CAH and are treated with corticosteroids [16,17,38]. It is more common, however, that corticosteroids are given until hormone analysis results are obtained [7,13,18,24,27,28,31,35,37,39]. Then, normal hormone levels [adrenocorticotropic hormone (ACTH), cortisol, 17-OHP] allow the exclusion of adrenal insufficiency.…”

Section: Discussionmentioning

confidence: 98%

“…et al [13] reported on 17 or 11 patients, respectively. Other reports with more than single cases included six [6,17], three [16,23,27,31,32] or two [18,20,[33][34][35][36][37] patients. Our patients exhibited clinical and laboratory features characteristic of THPA1, in keeping with those described in many previous reports [6,13,17,19,26,31].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Transient type 1 pseudo-hypoaldosteronism: report on an eight-patient series and literature review

et al. 2009

View full text Add to dashboard Cite

Eight boys aged 2-12 weeks with urinary tract malformations (UTMs) exhibited features of transient type 1 pseudo-hypoaldosteronism (TPHA1) in the course of urinary tract infection (UTI). Hyponatremia (120.9+/-5.8 mmol/l), hyperkalemia (6.9+/-0.9 mmol/l), metabolic acidosis (plasma bicarbonate 11+/-1.4 mmol/l), and a rise in serum creatinine levels (145+/-101 micromol/l) were associated with high urinary sodium (Na) and low potassium (K) excretion. Tubular resistance to aldosterone was indicated by high plasma aldosterone concentrations (170.4+/-100.5 ng/dl), high levels of the plasma aldosterone to potassium ratio (25.2+/-15.6), and diminished urinary K/Na values (0.31+/-0.19). With appropriate therapy, serum electrolytes, creatinine, and acid-base balance normalized within 2 weeks. A Medline search revealed another 85 cases of TPHA1 reported to date. All of the 93 patients were less than 7 months of age and 90% were less than 3 months of age, 90.3% suffered from UTM, with associated UTI in 89% of them, 11% had UTMin the absence of UTI, and 9.7% showed isolated UTI. These findings indicate that early infancy is the main contributing factor for TPHA1 to occur and that UTI and UTMare additional factors, with at least one being required for its development.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Transient type 1 pseudo-hypoaldosteronism: report on an eight-patient series and literature review

et al. 2009

View full text Add to dashboard Cite

show abstract

“…GBS is an unusual urinary tract pathogen and is highly associated with urinary tract malformation in children [5,6]. Only a few cases of GBS-related pseudohypoaldosteronism have been reported to date [7][8][9]. GBS urinary tract infection in an infant may result from hematogenous seeding of bacteria [10]; however, the blood culture was sterile in our case.…”

Section: Discussionmentioning

confidence: 56%

Transient Pseudohypoaldosteronism Secondary to Group B Streptococcus Pyelonephritis

Morisaki¹,

Naruse²,

Shibata³

et al. 2021

Cureus

View full text Add to dashboard Cite

Secondary pseudohypoaldosteronism is a condition characterized by aldosterone resistance in renal tubules. It is highly associated with urinary tract infection and urinary tract malformations. Only a few cases of pseudohypoaldosteronism secondary to group B Streptococcus pyelonephritis have been reported to date. A four-month-old boy developed poor sucking and weight loss, and his laboratory test results revealed hyponatremia, hyperkalemia, renal dysfunction, high anion gap metabolic acidosis, pyuria, and hydronephrosis. Laboratory tests including urinalysis confirmed the diagnosis of pseudohypoaldosteronism secondary to group B Streptococcus. He was treated with intravenous normal saline and antimicrobial therapy. Electrolyte disorders were addressed and he was discharged on the 10th day of hospitalization without any sequelae. Voiding cystourethrography performed after discharge showed bilateral grade 5 vesicoureteral reflux and intrarenal reflux in the right kidney. Transient pseudohypoaldosteronism is an important consideration in the differential diagnosis in infants with hyponatremia and hyperkalemia. A thorough evaluation for urinary tract malformations should be performed, including early abdominal ultrasonography and systemic management.

show abstract

“…As a result, these conditions are universally diagnosed in infancy. Acquired transient aldosterone resistance has been well reported in infants and children with obstructive uropathy and urinary tract infections/anomalies (2)(3)(4)(5). We herein report a patient with postileostomy hypovolemia presenting with a clinical and biochemical picture similar to pseudohypoaldosteronism.…”

Section: Introductionmentioning

confidence: 78%

A Case Of Postileostomy Hypovolemia Presenting As Pseudohypoaldosteronism With Complete Resolution After Ostomy Reversal

Niyazov

Shawa

2017

AACE Clinical Case Reports

View full text Add to dashboard Cite

Objective: To report a rare case of postileostomy hypovolemia presenting as pseudohypoaldosteronism with complete resolution after ostomy reversal. Methods: Clinical and biochemical data and extensive relevant literature review are provided. Results: A 65-year-old female was found to have a large rectal tubular adenoma 10 cm from the anal verge on colonoscopy. She underwent open resection of the polyp and diverting loop ileostomy. Six weeks later, she presented with low appetite, a 17-pound weight loss, and hypotension. Biochemical work-up revealed hyponatremia, hyperkalemia, low bicarbonate level, hypercalcemia, and remarkably elevated aldosterone and renin levels. All of the above abnormal clinical and biochemical findings had normalized after the ileostomy reversal. Conclusion: We report a case of postileostomy hypovolemia presenting as pseudohypoaldosteronism with complete resolution after ostomy reversal. It is probably not uncommon for patients with ileostomy to develop similar acid-base and electrolyte imbalances that resolve by volume repletion. Understanding the pathogenesis is critical to avoid unnecessary use of mineralocorticoids.

show abstract

Two cases of transient pseudohypoaldosteronism due to group B streptococcus pyelonephritis

Cited by 8 publications

References 4 publications

Transient type 1 pseudo-hypoaldosteronism: report on an eight-patient series and literature review

Transient type 1 pseudo-hypoaldosteronism: report on an eight-patient series and literature review

Transient Pseudohypoaldosteronism Secondary to Group B Streptococcus Pyelonephritis

A Case Of Postileostomy Hypovolemia Presenting As Pseudohypoaldosteronism With Complete Resolution After Ostomy Reversal

Contact Info

Product

Resources

About