Two CD14 promoter polymorphisms and atopic phenotypes in Czech patients with IgE‐mediated allergy

Bučková, Dana; Hollá, Lýdie Izakovičová; Schüller, Marcel; Znojil, Vladimı́r; Vácha, Jiří

doi:10.1034/j.1398-9995.2003.00271.x

Cited by 53 publications

(61 citation statements)

References 12 publications

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“…10 Further, associations between other autoimmune diseases and TLR4 are reported in some, 11,12 but not all studies. [13][14][15] Likewise, asthma has in some studies been associated with polymorphisms in TLR2, 16 TLR4 17 and CD14, 18 but not in others. [19][20][21] Epidemiological studies suggest a negative relation between asthma and T1D 22 and certain genes appear to have associations in opposite directions for these two diseases.…”

Section: Introductionmentioning

confidence: 99%

A TLR2 polymorphism is associated with type 1 diabetes and allergic asthma

et al. 2009

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Type 1 diabetes (T1D) and allergic asthma are immune-mediated diseases. Pattern recognition receptors are proteins expressed by cells in the immune system to identify microbial pathogens and endogenous ligands. Toll-like receptors (TLRs) and CD14 are members of this family and could represent a molecular link between microbial infections and immune-mediated diseases. Diverging hypotheses regarding whether there exists a common or inverse genetic etiology behind these immunemediated diseases have been presented. We aimed to test whether there exist common or inverse associations between polymorphisms in the pattern recognition receptors TLR2, TLR4 and CD14 and T1D and allergic asthma. Eighteen single nucleotide polymorphisms (SNPs) were genotyped in TLR2 (2), TLR4 (12) and CD14 (4) in 700 T1D children, 357 nuclear families with T1D children and 796 children from the 'Environment and Childhood Asthma' study. Allele and haplotype frequencies were analyzed in relation to diseases and in addition transmission disequilibrium test analyses were performed in the family material. Both T1D and allergic asthma were significantly associated with the TLR2 rs3804100 T allele and further associated with the haplotype including this SNP, possibly representing a susceptibility locus common for the two diseases. Neither TLR4 nor CD14 were associated with T1D or allergic asthma.

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Section: Introductionmentioning

confidence: 99%

A TLR2 polymorphism is associated with type 1 diabetes and allergic asthma

et al. 2009

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“…This review demonstrated different effects of genetic variations in atopic (36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48) and non-atopic wheezing. (31)(32)(33)(34)(35) These differences should be interpreted considering the role of these genes on airway inflammation and atopy.…”

Section: Final Considerationsmentioning

confidence: 99%

Genetic associations with asthma and virus-induced wheezing: a systematic review

2009

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Various wheezing phenotypes can be identified based on differences in natural histories, risk factors and responses to treatment. In epidemiologic studies, atopic asthma or virus-induced wheezing can be discriminated by the presence or the absence of sensitization to allergens. Children with asthma have been shown to present lower levels of lung function. Patients with viral respiratory infections evolve from normal lung function to enhanced airway reactivity. The objective of this study was to identify genes and polymorphisms associated with different wheezing phenotypes. Using data obtained from the Genetic Association Database, we systematically reviewed studies on genes and polymorphisms that have been associated with virus-induced wheezing or atopic asthma. The research was carried out in February of 2009. Genes associated with the studied outcomes in more than three studies were included in the analysis. We found that different genes and loci have been associated with virus-induced wheezing or atopic asthma. Virus-induced wheezing has frequently been associated with IL-8 polymorphisms, whereas atopic asthma and atopy have frequently been associated with Th2 cytokine gene (CD14 and IL-13) polymorphisms on chromosome 5. This review provides evidence that different wheezing disorders in childhood can be differently affected by genetic variations, considering their role on airway inflammation and atopy. Future studies of genetic associations should consider the different wheezing phenotypes in infancy. In addition, stratified analyses for atopy can be useful for elucidating the mechanisms of the disease.Keywords: Genetics; Polymorphism, genetic; Asthma; Interleukins; Respiratory syncytial viruses. ResumoDiversos fenótipos de sibilância têm sido identificados com base em diferenças na história natural, fatores de risco e resposta ao tratamento. Em estudos epidemiológicos, a asma atópica ou sibilância induzida por vírus pode ser discriminada pela presença ou ausência de sensibilização a alérgenos. As crianças com asma apresentam níveis menores de função pulmonar. Pacientes com infecções respiratórias virais apresentam-se com função pulmonar normal, mas mostram reatividade da via aérea aumentada. O objetivo deste trabalho foi identificar genes e polimorfismos associados aos diferentes fenótipos de sibilância. Utilizando dados do Genetic Association Database, foi realizada uma revisão sistemática de estudos sobre genes e polimorfismos associados à sibilância induzida por vírus ou à asma atópica. O levantamento foi realizado em fevereiro de 2009. Todos os genes associados com o desfecho estudado presentes em mais de três estudos foram incluídos na análise. Identificamos que diferentes genes e locos têm sido associados à sibilância induzida por vírus ou à asma atópica. Enquanto a sibilância induzida por vírus foi mais frequentemente associada a polimorfismos no gene IL-8, polimorfismos localizados em genes de citocinas Th2 no cromossomo 5 (CD14 e IL-13) foram frequentemente associados à atopia ou à asma atóp...

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“…The result seems to be consistent with reports from the Collaborative Study of the Genetics of Asthma, which indicated that linkage between markers in chromosome 5q and asthma was present among non-Hispanic whites but not Hispanic subjects. Similar studies were applied to many racial/ethnic groups, such as subjects in the Czech (Buckova et al 2003), Dutch, (Koppelman et al 2001) and Hong Kong Chinese (Leung et al 2003) populations, which showed association between IgE level and CD14/ À159 polymorphism, but not in German (Sengler et al 2003) and Polish (Lis et al 2001) populations. Not surprisingly, these inconsistent data suggest the CD14/À159 polymorphism may only be one of many mechanisms involved in IgE regulation.…”

Section: Introductionmentioning

confidence: 99%

Association study using combination analysis of SNP and STRP markers: CD14 promoter polymorphism and IgE level in Taiwanese asthma children

Wang

Lin

et al. 2004

J Hum Genet

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Chromosome 5, especially the 5q31-33 region, may contain one or more loci to control total serum IgE as well as asthma and bronchial hyperresponsiveness. To investigate the regions related with IgE level in chromosome 5, we performed a case-control association study on 105 high-IgE-level and 85 normal-IgE-level asthmatic children using 43 microsatellite markers that span the whole chromosome 5 with 5 cM intervals. One of microsatellite marker, D5S2011, had significantly different allele frequency between the two asthmatic groups. E allele (143 bp) of the D5S2011 marker was more frequent in high-IgE asthmatics. CD14 is the candidate gene of atopy and asthma and is distant from D5S2011 by about 1 Mb. We analyzed the SNP genotypes in the CD14 gene region alone and in combination with microsatellite marker D5S2011. The CD14/À2984 polymorphism but not the CD14/À159 is associated with IgE level in Taiwanese asthmatic children. The CD14/À159 allele was observed only to be associated with IgE level when À159T was part of a haplotype containing a D5S2011 E allele. The combination analysis using SNP and STRP markers provided a novel method for increasing detection power in candidate gene association studies.

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Two CD14 promoter polymorphisms and atopic phenotypes in Czech patients with IgE‐mediated allergy

Abstract: Our study supports the idea that CD14 gene variants may act as disease modifiers of IgE-mediated allergic diseases.

Cited by 53 publications

References 12 publications

A TLR2 polymorphism is associated with type 1 diabetes and allergic asthma

A TLR2 polymorphism is associated with type 1 diabetes and allergic asthma

Genetic associations with asthma and virus-induced wheezing: a systematic review

Association study using combination analysis of SNP and STRP markers: CD14 promoter polymorphism and IgE level in Taiwanese asthma children

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