2021
DOI: 10.1177/10668969211037915
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Two Components of Variant Profiles in Primary Vaginal Carcinosarcoma via Next-Generation Sequencing and a Literature Review

Abstract: Primary vaginal carcinosarcoma (VCS) is an extremely rare and aggressive tumor consisting of admixed malignant epithelial and mesenchymal elements. We report a case of VCS that was subjected to analysis by immunohistochemistry and next-generation sequencing (NGS). A 53-year-old woman with post-menopausal vaginal bleeding underwent surgical excision followed by concurrent chemoradiation. A well demarcated tumor was growing in a discontinuous fashion at a location some distance from both the cervix and vulva. Mi… Show more

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“…Cervical carcinosarcoma is one of its types, and the literature on cervical carcinosarcoma is currently limited to case reports ( 4 ). It is also named a malignant mixed mesodermal tumor, which is composed of a carcinomatous component and a sarcomatous component; malignant mixed Müllerian tumor; or metaplastic carcinoma ( 5 ). In this study, we report a 54-year-old female who was diagnosed with highly differentiated endometrial adenocarcinoma with cervical carcinosarcoma.…”
Section: Introductionmentioning
confidence: 99%
“…Cervical carcinosarcoma is one of its types, and the literature on cervical carcinosarcoma is currently limited to case reports ( 4 ). It is also named a malignant mixed mesodermal tumor, which is composed of a carcinomatous component and a sarcomatous component; malignant mixed Müllerian tumor; or metaplastic carcinoma ( 5 ). In this study, we report a 54-year-old female who was diagnosed with highly differentiated endometrial adenocarcinoma with cervical carcinosarcoma.…”
Section: Introductionmentioning
confidence: 99%