Two copper complexes from two novel naphthalene-sulfonyl-triazole ligands: Different nuclearity and different DNA binding and cleavage capabilities

A structural and biological study on the new 3,5-diacetyl-1,2,4-triazol bis(p-chlorophenylthiosemicarbazone) ligand and its bimetallic complexes

“…Both compounds exhibit similar patterns: initially, at a low concentration of the compound, a clear diminution of the viscosity is observed suggesting a bending of the DNA chain probably due to strong hydrogen bonding interactions; however, when the concentration of the compound increases, a slight increase of the viscosity is observed pointing to groove binding interactions as the dominant DNA interactions. 37,38 Thus, these results provide further support for the groove binding mode between these compounds and DNA.…”

Synthesis, antibacterial activity and DNA interactions of lanthanide(III) complexes of N(4)-substituted thiosemicarbazones

“…Previous studies have been Abstract This paper reports the synthesis and detailed characterization of six novel lanthanide complexes of La(III), Eu(III) and Nd(III) with N (4)-substituted thiosemicarbazones derived from the 2-carboxybenzaldehyde. The IR, 1 H-NMR and 13 C-NMR spectroscopic studies confirmed the coordination of the thiocarbonyl (C=S), azomethine (C=N) and carboxylate (COO − ) groups to the metal centers, and the carboxylate was coordinated in a bidentate manner. The elemental and thermal analyses suggest that lanthanide complexes were formed in 1:2 molar ratios (metal:ligand).…”

“…Additionally, the studies on the interactions between metal complexes and DNA strands have offered some ideas regarding the possible mechanisms of action; numerous compounds that are cytotoxic to tumoral cells can bind to DNA strands. Thereby, the evaluation of the interactions that these types of molecules may have with the DNA provides an initial understanding of their biological activity [13][14][15][16][17]. Thus, considering the potential therapeutic uses of thiosemicarbazones and lanthanide complexes and in order to contribute to the discovery of new molecules able to fight antimicrobial resistance, the aim of this research is to describe the synthesis and characterization of La(III), Nd(III) and Eu(III) complexes of N (4)-(4-R-phenyl) thiosemicarbazones derived from the 2-carboxybenzaldehyde.…”

Theoretical study on binding models of copper nucleases containing pyridyl groups to DNA

“…Eight copper complexes that involve the ligands with the very similar structures also show different biological activities [10,11,14,25,26].…”