Two-dimensional cancer theranostic nanomaterials: Synthesis, surface functionalization and applications in photothermal therapy

Murugan, Chandran; Sharma, Varsha; Murugan, Rajesh Kumar; Malaimegu, Gnanasekar; Sundaramurthy, Anandhakumar

doi:10.1016/j.jconrel.2019.02.015

Cited by 177 publications

(95 citation statements)

References 163 publications

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“…During recent years, cancer has become a major health crisis throughout the globe costing thousands of lives each year. According to the World Health Organization (WHO), every sixth death in the world is caused by cancer [ 112 ]. The existing treatments, such as chemotherapy and radiation therapy, can be challenging due to harmful effects exerted on adjacent healthy tissues.…”

Section: Biomedical Applications Of Nanochitosanmentioning

confidence: 99%

“…The high doses of radiation used in radiotherapy are known to heighten the invasive properties of cancer cells, and certain cancer types have developed resistance to the radiation. Hence, targeted thermal treatments such as photothermal therapy have gained the attention of scientists due to its advantages such as cost-effectiveness, reduced side effects, and noninvasive nature [ 112 ]. Nanoparticles containing photothermal agents introduced into tumor sites can be induced by near-infrared (NIR) light in the wavelength range at first (700–980 nm) or second (1000–1400 nm) biological window [ 113 ].…”

Section: Biomedical Applications Of Nanochitosanmentioning

confidence: 99%

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Agricultural and Biomedical Applications of Chitosan-Based Nanomaterials

et al. 2020

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Chitosan has emerged as a biodegradable, nontoxic polymer with multiple beneficial applications in the agricultural and biomedical sectors. As nanotechnology has evolved as a promising field, researchers have incorporated chitosan-based nanomaterials in a variety of products to enhance their efficacy and biocompatibility. Moreover, due to its inherent antimicrobial and chelating properties, and the availability of modifiable functional groups, chitosan nanoparticles were also directly used in a variety of applications. In this review, the use of chitosan-based nanomaterials in agricultural and biomedical fields related to the management of abiotic stress in plants, water availability for crops, controlling foodborne pathogens, and cancer photothermal therapy is discussed, with some insights into the possible mechanisms of action. Additionally, the toxicity arising from the accumulation of these nanomaterials in biological systems and future research avenues that had gained limited attention from the scientific community are discussed here. Overall, chitosan-based nanomaterials show promising characteristics for sustainable agricultural practices and effective healthcare in an eco-friendly manner.

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Section: Biomedical Applications Of Nanochitosanmentioning

confidence: 99%

Section: Biomedical Applications Of Nanochitosanmentioning

confidence: 99%

Agricultural and Biomedical Applications of Chitosan-Based Nanomaterials

et al. 2020

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“…Many reviews have been published, so far, based on 2D theranostic nanomaterials demonstrating various therapies and treatments. They have listed theranostic application of such nanomaterials with respect to biomedical imaging, photothermal conversion efficiency, and dimensional values, including size and thickness of the nanomaterials [65][66][67]. Some literature showed their biological effects randomly either with in vitro or in vivo treatment [65,68].…”

Section: Two-dimensional Theranostic Nanomaterialsmentioning

confidence: 99%

Two-Dimensional Theranostic Nanomaterials in Cancer Treatment: State of the Art and Perspectives

Raja

Kang

Kim

et al. 2020

Cancers

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As the combination of therapies enhances the performance of biocompatible materials in cancer treatment, theranostic therapies are attracting increasing attention rather than individual approaches. In this review, we describe a variety of two-dimensional (2D) theranostic nanomaterials and their efficacy in ablating tumors. Though many literature reports are available to demonstrate the potential application of 2D nanomaterials, we have reviewed here cancer-treating therapies based on such multifunctional nanomaterials abstracting the content from literature works which explain both the in vitro and in vivo level of applications. In addition, we have included a discussion about the future direction of 2D nanomaterials in the field of theranostic cancer treatment.

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“…In particular, PTT uses heat which is generated from photosensitizer absorbed light to eradicate target tumors, noninvasively. [1,2] Ideal gap (0.3-2.0 eV), leading to excellent light-matter interaction in the infrared region that includes infrared biowindows for lightactivated therapy. [32][33][34][35][36] As a result, BP based light-activated biomedicine materials have been explored in various bio-photonics applications, such as PDT, [37,38] PTT, [39][40][41] bio-imaging, [40,42] and biosensors.…”

Section: Introductionmentioning

confidence: 99%

Smart Acid‐Activatable Self‐Assembly of Black Phosphorous as Photosensitizer to Overcome Poor Tumor Retention in Photothermal Therapy

Wang

Xie

Kang

et al. 2020

Adv Funct Materials

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Nanomaterials-based photothermal therapy (PTT) could efficiently eliminate cancer cells in a noninvasive manner. However, nanoscale photosensitizers still suffer from several drawbacks, limiting them from being an ideal PTT approach against cancer. These include unfavorable biodistribution and poor retention in tumor tissue. In this study, acid-activatable smart selfassembly of black phosphorous (BP) and polyoxometalates (POM) is carried out to yield POM@BP with prolonged tumor retention and enhanced efficacy of PTT. The as-rationally designed POM@BP photosensitizers in acidic tumor microenvironments self-assemble into nanoparticles with larger sizes, remarkably increasing the light absorption ability of BP nanosheets in PTT of cancer. The as-obtained POM@BP endows prolonged retention and enhances the photothermal response in tumor tissue by smart self-assembly of BP into larger nanoparticles. In summary, the proposed potent approach for the rational design and tailor photosensitizer for cancer treatment looks very promising for future scientific breakthroughs in nanomedicine.

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Two-dimensional cancer theranostic nanomaterials: Synthesis, surface functionalization and applications in photothermal therapy

Cited by 177 publications

References 163 publications

Agricultural and Biomedical Applications of Chitosan-Based Nanomaterials

Agricultural and Biomedical Applications of Chitosan-Based Nanomaterials

Two-Dimensional Theranostic Nanomaterials in Cancer Treatment: State of the Art and Perspectives

Smart Acid‐Activatable Self‐Assembly of Black Phosphorous as Photosensitizer to Overcome Poor Tumor Retention in Photothermal Therapy

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