Two-Dimensional Theranostic Nanomaterials in Cancer Treatment: State of the Art and Perspectives

Raja, Iruthayapandi Selestin; Kang, Moon Sung; Kim, Ki Su; Jung, Yu Jin; Han, Dong‐Wook

doi:10.3390/cancers12061657

Cited by 23 publications

(14 citation statements)

References 130 publications

(198 reference statements)

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“…Additionally, MnO 2 chemical properties predestine this compound to be a base for theranostic solutions. Due to the specific conditions characteristic for tumour microenvironment (TME)—low pH, high GSH level and H 2 O 2 concentration [ 34 , 35 ]—MnO 2 NPs can play a role as a carrier of chosen drug that can be released after the dissolution of NPs into Mn 2+ [ 36 ]. Released Mn 2+ ions can react with H 2 O 2 present in the TME, decreasing hypoxia and changing the environment to be less favourable for tumour cells.…”

Section: Medical Applications Of Manganese and Manganese Oxide Nanoparticlesmentioning

confidence: 99%

Applications and Biological Activity of Nanoparticles of Manganese and Manganese Oxides in In Vitro and In Vivo Models

et al. 2021

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The expanding applications of nanotechnology seem to be a response to many technological, environmental, and medical challenges. The unique properties of nanoparticles allow for developing new technologies and therapies. Among many investigated compounds is manganese and its oxides, which in the form of nanoparticles, could be a promising alternative for gadolinium-based contrast agents used in diagnostic imaging. Manganese, which is essential for living organisms as an enzyme cofactor, under excessive exposure—for example, due to water contamination or as an occupational hazard for welders—can lead to neurological disorders, including manganism—a condition similar to Parkinson’s disease. This review attempts to summarise the available literature data on the potential applications of manganese and manganese oxide nanoparticles and their biological activity. Some of the published studies, both in vitro and in vivo, show negative effects of exposure to manganese, mainly on the nervous system, whereas other data suggest that it is possible to develop functionalised nanoparticles with negligible toxicity and novel promising properties.

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Section: Medical Applications Of Manganese and Manganese Oxide Nanoparticlesmentioning

confidence: 99%

Applications and Biological Activity of Nanoparticles of Manganese and Manganese Oxides in In Vitro and In Vivo Models

et al. 2021

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“…This has led to the establishment of a new multi-disciplinary research domain known as theranostics. Examples of theranostic nanomaterials are iron-based metal oxide magnetic nanocrystals, MXene, black phosphorus (BP), graphene oxide (GO), manganese dioxide (MnO 2 ), and palladium (Pd) [ 5 , 6 ]. In addition to those, an emerging class of materials with theranostic potential is represented by nanozymes (NZs).…”

Section: Introductionmentioning

confidence: 99%

Transition Metal Dichalcogenides (TMDC)-Based Nanozymes for Biosensing and Therapeutic Applications

et al. 2022

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Nanozymes, a type of nanomaterial with enzyme-like properties, are a promising alternative to natural enzymes. In particular, transition metal dichalcogenides (TMDCs, with the general formula MX2, where M represents a transition metal and X is a chalcogen element)-based nanozymes have demonstrated exceptional potential in the healthcare and diagnostic sectors. TMDCs have different enzymatic properties due to their unique nano-architecture, high surface area, and semiconducting properties with tunable band gaps. Furthermore, the compatibility of TMDCs with various chemical or physical modification strategies provide a simple and scalable way to engineer and control their enzymatic activity. Here, we discuss recent advances made with TMDC-based nanozymes for biosensing and therapeutic applications. We also discuss their synthesis strategies, various enzymatic properties, current challenges, and the outlook for future developments in this field.

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“…As a result, 2D nanomaterials were extensively applied in various biomedical applications, such as, in drug/gene delivery, tissue engineering, biosensors, biomedical imaging, etc. One of the important feature of the 2D nanomaterials is having larger specific area that allows adsorption/absorption of various small molecules, including drugs, photosensitizing molecules, and functional nanoparticles. − Dimensionality and the planar structure of 2D nanomaterials are the most influential material parameters, which allow them to be activated by using light. 2D nanomaterials show strong and extended optical absorption in the NIR region, which makes them suitable for light triggered imaging applications, photothermal therapy (PTT), and photodynamic therapy (PDT).…”

Section: Introductionmentioning

confidence: 99%

Near-Infrared Light Activatable Two-Dimensional Nanomaterials for Theranostic Applications: A Comprehensive Review

Hiremath

Kumar

Hwang

et al. 2022

ACS Appl. Nano Mater.

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Two-dimensional (2D) layered nanomaterials possess high surface area, unique structure, and extraordinary physicochemical, optical, and electrical properties and have attracted tremendous interests in the field of biomedical research. Several types of 2D nanomaterials, including graphene and its derivatives, black phosphorus (BP) nanosheets, graphitic carbon nitride, MXenes, and transition metal dichalcogenides (TMDCs), have been extensively utilized for phototheranostic applications. Besides their unique optical properties and high surface area, these nanomaterials can facilitate loading of different guest molecules for enabling phototherapeutic outcomes. Furthermore, various other nanoparticles or molecules can be decorated to improve the optical absorption in the near-infrared (NIR) region, biocompatibility, and achieve excellent theranostic capabilities which make them promising candidates for future biomedical/clinical applications. Herein, we review the recent progress of NIR light activatable 2D nanomaterials for theranostic applications. The current challenges and future perspectives have also been discussed.

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Two-Dimensional Theranostic Nanomaterials in Cancer Treatment: State of the Art and Perspectives

Cited by 23 publications

References 130 publications

Applications and Biological Activity of Nanoparticles of Manganese and Manganese Oxides in In Vitro and In Vivo Models

Applications and Biological Activity of Nanoparticles of Manganese and Manganese Oxides in In Vitro and In Vivo Models

Transition Metal Dichalcogenides (TMDC)-Based Nanozymes for Biosensing and Therapeutic Applications

Near-Infrared Light Activatable Two-Dimensional Nanomaterials for Theranostic Applications: A Comprehensive Review

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