Covariant density functional theory and three-dimensional tilted axis cranking are used to investigate multiple chirality in nuclear rotation for the first time in a fully self-consistent and microscopic way. Two distinct sets of chiral solutions with negative and positive parities, respectively, are found in the nucleus 106 Rh. The negative-parity solutions reproduce well the corresponding experimental spectrum as well as the B(M 1)/B(E2) ratios of the transition strengths. This indicates that a predicted positive-parity chiral band should also exist. Therefore, it provides a further strong hint that multiple chirality is realized in nuclei. two chiral systems differ from each other by their intrinsic chirality, and are thus related by the chiral operator T R(π) that combines time reversal T and spatial rotation by π.The broken chiral symmetry in the body-fixed frame should be restored in the laboratory frame. This gives rise to the so-called chiral doublet bands, which consist of a pair of nearly-degenerate ∆I = 1 sequences with the same parity (for reviews see Refs. [2,3]).The chiral geometry of a rotating triaxial nucleus requires substantial angular momentum components along all of the three principal axes. For actual nuclear systems, this relates to configurations where high-j valence particles and holes align along the short and long axes, respectively, and the collective core rotates around the intermediate axis.Based on such configurations, so far, many candidates for chiral doublet bands have been reported experimentally in the A ∼ 80, 100, 130, and 190 mass regions of the nuclear chart; see e.g.Figure 1: (color online). A schematic picture for the aplanar rotation of a triaxial nucleus. The arrow J denotes the total angular momentum vector, and the short, intermediate, and long axes are denoted by x, y, and z, respectively.These observations indicate that chirality is not restricted to a specific configuration in a certain mass region. In particular, two pairs of chiral bands with different configurations were discussed respectively in Refs. [8,9] for 105 Rh. The resultant possibility of having more than one pair of chiral bands in a single nucleus was demonstrated by searching for triaxial chiral configurations in Rh isotopes using constrained relativistic mean-field calculations in Ref. [19], which introduced the acronym MχD for multiple chiral doublet bands. Further studies were carried out in Refs. [20,21,22]. Strong