Two‐dimensional correlation infrared spectroscopy applied to the identification of ephedrine and pseudoephedrine in illegally adulterated slimming herbal products

Li, Miao; Liu, Yan; Li, Hao; Qi, Yunpeng; Lu, Feng

doi:10.1002/dta.1963

Cited by 20 publications

(8 citation statements)

References 33 publications

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“…Sibutramine is a FDA approved anti-obesity compound which has been withdrawn from the market after approving its clinical side effects on cardiovascular functions such as myocardial infarction, cardiac arrhythmia, uncontrolled hypertension, and stroke [24,25]. In addition to product number 3, sibutramine was identified in the six other products [4,[6][7][8]13,14].…”

Section: Results Of Chromatographic Analysesmentioning

confidence: 99%

“…Natural anti-obesity products have been always considered as attractive alternatives to synthetic products as they are publically advertised as products containing purely natural ingredients with lacking specific side effects [8,9]. The truth is that such herbal products seem to be weaker than synthetic slimming products and it could be nearly impossible to achieve rapid short-term effects, therefore some manufacturers often illegally add synthetic pharmaceutical drugs to the natural product to improve their efficacy and achieve huge profits, while the presence of these ingredients could not be discriminated due to misleading packaging [10][11][12][13]. Unfortunately, continuous consumption of chemical slimming products, which are illegally adulterated with synthetic materials, may cause severe harms to patients and could be considered as a threat to individual's health and even a reason for mortality [14].…”

Section: Introductionmentioning

confidence: 99%

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Screening and Confirmation of Different Synthetic Adulterants in Slimming Products

Fakhri

Mohammadi

Jalili

et al. 2018

Asian J Pharm Clin Res

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Objective: The presence of synthetic drugs (as adulterant) in slimming herbal products of world markets has contravened the country's law and has created many troubles for some consumers of slimming products. This study aims to use a simple and reliable method for simultaneously finding and validating the presence of possible adulterants in some slimming products, which could not be discriminated due to misleading packaging.Method: Fifteen slimming products were obtained from the Iran pharmaceutical markets. Liquid chromatography-ultraviolet and LC-mass spectrometry methods were performed for simultaneous screening and confirmation of adulterants. Results:The most abundant adulterant was Phenolphthalein, which has been used in 11 cases of the 15 slimming products. Furthermore, 5 products included caffeine, two included phendimetrazine, and two included protriptyline. Conclusion:The performed method was successful in detection of different adulterants. According to the presence of synthetic drugs in slimming herbal products, and their threats to people's health it is necessary to create awareness in this case through public authorities.

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Section: Results Of Chromatographic Analysesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Screening and Confirmation of Different Synthetic Adulterants in Slimming Products

Fakhri

Mohammadi

Jalili

et al. 2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

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“…In the literature are available numerous analytical applications of power spectra for identification and classification of traditional Chinese medicine. [11][12][13][14] In these studies, the power spectra are used as simple fingerprints of different samples. In contrast, this work focuses on application of the power spectra for structure and interaction studies.…”

Section: Introductionmentioning

confidence: 99%

Two-Dimensional Correlation Spectroscopy: The Power of Power Spectra

Czarnecki

2020

Appl Spectrosc

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Power spectra are a powerful tool provided by two-dimensional correlation analysis. However, this tool is seldom used in practice. This work shows selected examples of using of the power spectra for the study of various kinds of samples with the aim to promote more common use of this tool. By examination of the power spectrum of specific sample, one can estimate the sensitivity of different molecular fragments on a given perturbation. Determination of the power spectra for smaller data subsets provides information on the dynamics of perturbation-induced spectral changes. If the experimental spectra of different samples in the same perturbation window are recorded, the comparison of the power spectra yields information on differences in the sensitivity of various samples on common perturbation. This possibility is particularly useful for studies of the spectra-structure correlations, interactions, and molecular dynamics. A comparison of the power spectra obtained by using different reference spectra provides information on the nature of spectral changes at different wavenumbers.

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“…Studies have simulated CBL and CBG vibrational and electronic spectra for identification and characterization purposes . There are other examples in which the DFT has been applied to provide spectral properties for other NPS. − …”

Section: Introductionmentioning

confidence: 99%

In Silico Infrared Characterization of Synthetic Cannabinoids by Quantum Chemistry and Chemometrics

Castro

Rodrigues

Bruni

2020

J. Chem. Inf. Model.

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The concept of forensic sciences as mere trace analysis has been modified by the idea of forensic intelligence, which entails applying data to make decisions within the investigative process. Many countries are engaged in combating drug trafficking and drug use because they are related to public health and safety issues. Prohibiting the consumption of traditional drugs has led new psychoactive substances (NPSs) to emerge. NPSs consist of compounds that resemble the initially banned substance and which aim to mimic the traditional drug recreational effects while circumventing drug legislation. For example, synthetic cannabinoids are sprayed on herbal products to reproduce the cannabis recreational effects. According to the United Nations Office on Drugs and Crime (UNODC), the toxic effects of synthetic cannabis types are unknown, and harm and fatalities associated with the use of these drugs have been reported. Information on the characterization related to these species is lacking. The rate at which NPSs appear poses a significant challenge because employing conventional methods to understand the characteristics of these compounds may require time and be costly. This work uses in silico practices as an alternative to understand how NPSs related to cannabis behave. We apply quantum chemistry methods to evaluate several synthetic cannabinoids recognized in forensic samples. More specifically, we generate infrared spectra that can be employed as a benchmark for NPSs. We apply a multivariate classification to evaluate the results. We conclude that in silico methods are an alternative that provide information about the spectra of undetected substances. This information can help to identify new drugs, to increase knowledge about them, and to feed information procedures.

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Two‐dimensional correlation infrared spectroscopy applied to the identification of ephedrine and pseudoephedrine in illegally adulterated slimming herbal products

Cited by 20 publications

References 33 publications

Screening and Confirmation of Different Synthetic Adulterants in Slimming Products

Screening and Confirmation of Different Synthetic Adulterants in Slimming Products

Two-Dimensional Correlation Spectroscopy: The Power of Power Spectra

In Silico Infrared Characterization of Synthetic Cannabinoids by Quantum Chemistry and Chemometrics

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