Two‐Dimensional Correlation Spectroscopy: New Developments and Applications

Abstract

This article outlines the recent progress in two‐dimensional (2D) correlation spectroscopy, especially new and noteworthy developments and its applications. 2D correlation spectroscopy is a powerful technique used to analyze effectively various spectral data, especially those obtained in various spectroscopic experiments. 2D correlation spectroscopy has undergone rapid developments. This article highlights new types of 2D correlation analysis, such as combination of chemometrics and 2D correlation spectroscopy, projection 2D analysis, and heterocorrelation analysis, as well as experimental practices, such as various perturbation methods, fields of applications, and analytical probes employed.

Size-Dependent Surface-Enhanced Raman Scattering Activity of Ag@CuxOS Yolk–Shell Nanostructures: Surface Plasmon Resonance Induced Charge Transfer

“…If the signs of the cross peaks of the synchronous and asynchronous correlation spectra are the same, the intensity change at 1 occurs before that at 2. However, if the signs are different, the intensity change at 1 occurs after that at 2 [2][3][4].…”

Two-dimensional correlation spectroscopy in polymer study

“…The detailed background of the generalized 2DCOS is well introduced in books and book chapters (Noda, 2002 , 2009 ; Ozaki, 2002 ; Noda and Ozaki, 2004 ; Ozaki and Šašic, 2005 ; Ozaki and Noda, 2006 ; Noda and Lindsey, 2010 ; Czarnik-Matusewicz and Jung, 2014 ; Jung and Noda, 2014 ) and review articles (Noda et al, 1993 , 2000 ; Noda, 2000 , 2004 , 2006 , 2007 , 2008 , 2014a , b ; Jung and Noda, 2014 ). Here, we briefly describe the basic concept of 2DCOS.…”

Probing the Stepwise Unfolding of Bovine Serum Albumin Using 2D Correlation Raman Spectroscopic Analysis

“…Here, we have tried to probe the sequence of events using two-dimensional (2D) correlation Raman spectra analyses obtained at various concentrations of GuHCl. Two-dimensional correlation (2D Cos) is a perturbation-based analysis technique that characterizes the dynamic features of the data by displaying the variations that occur during the measurement. − As there are various secondary structural units present in the protein, a sequential analysis of the folding process can shed light on units favoring folding or destabilization. ,− 2D Cos analysis has been widely used for analyzing the sequence of events during unfolding of proteins. , The dynamics of the unfolding of BSA in a lower concentration of GuHCl is significantly different from that of the higher region. Interestingly, small turns connecting various helices have been seminal in assisting the unfolding of BSA in the higher region.…”

“…21,23−25 2D Cos analysis has been widely used for analyzing the sequence of events during unfolding of proteins. 22,26 The dynamics of the unfolding of BSA in a lower concentration of GuHCl is significantly different from that of the higher region. Interestingly, small turns connecting various helices have been seminal in assisting the unfolding of BSA in the higher region.…”