Two-dimensional gradient platforms for rapid assessment of dental polymers: A chemical, mechanical and biological evaluation☆

Effects of filler type and content on mechanical properties of photopolymerizable composites measured across two-dimensional combinatorial arrays

“…The specimen was then further cured for 1 min per side. A schematic of the setup is provided in an earlier publication [14]. Specimens were stored in the dark for 24 h prior to characterization to ensure that the DC no longer changed with time.…”

“…The specimens were fabricated by adapting procedures previously used for specimens of unfilled polymers [14]. Briefly, a sample mold was prepared using two glass slides (50 mm  75 mm), a polyester release film and a poly(dimethylsiloxane) spacer (thickness %1.5 mm) with five channels (3 mm  60 mm).…”

“…Our previous studies focused on two-dimensional (2-D) composition arrays and degree of conversion (DC) gradients of dental polymers using a monomer system consisting of binary mixtures of bisphenol A-glycidyl dimethacrylate (BisGMA) and triethylene glycol dimethacrylate (TEGDMA) [14]. We have also studied biocompatibilities of dental polymers [13,14] and composites [15] using 2-D platforms. In the current study, we investigated the effects of filler size and concentration on various chemical, physical and mechanical properties, in addition to biological properties.…”

Gradient and Microfluidic Library Approaches to Polymer Interfaces

“…For example, Lin-Gibson and coworkers used this library technique to examine structureproperty relationships in photopolymerized dimethacrylate networks [38] and to screen the mechanical and biocompatibility performance of photopolymerized dental resins [39]. In another set of recent studies, Johnson and coworkers combined graded light exposure with temperature and composition gradients to map and model the photopolymerization kinetics of acrylates, thiolenes and a series of co-monomer systems [40][41][42].…”

Sample Geometry Influences the Outcome of in vitro Cytotoxicity Tests

“…[8,9] In order to determine how the cytotoxicity of extracts of materials and the cytotoxicity of test specimen in direct contact with the cells compare to each other we have utilized the direct contact tests and the tests of extracts of materials with dental composites and compared the cytotoxicity data of both types of tests with each other. From the results obtained with test specimen extracts we recommend to always extract a surface area of 6 cm 2 in one millilitre of cell culture medium.…”