Two‐dimensional graphene oxide‐reinforced porous biodegradable polymeric nanocomposites for bone tissue engineering

Farshid, Behzad; Lalwani, Gaurav; Mohammadi, Meisam Shir; Sankaran, Jeyantt Srinivas; Patel, Sunny C.; Judex, Stefan; Simonsen, John Lionel; Sitharaman, Balaji

doi:10.1002/jbm.a.36606

Cited by 23 publications

(11 citation statements)

References 58 publications

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“…The developed composites showed excellent features in terms of thermal stability, mechanical performance, water absorption, hydrophilicity, hydrolytic degradation, protein absorption capability, cytotoxicity viscoelastic, and antibacterial properties. In addition, cell viability experiments have been performed, demonstrating that PPF/PEG-GO nanocomposites do not lead to toxic effects on normal human dermal fibroblasts (NHDF) and other cell types, suggesting, so far, a considerable potential for medical utilization, principally for bone tissue engineering applications [ 40 , 41 , 42 , 43 ].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

An Update on Graphene-Based Nanomaterials for Neural Growth and Central Nervous System Regeneration

Tupone

Panella

Castelli

et al. 2021

IJMS

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Thanks to their reduced size, great surface area, and capacity to interact with cells and tissues, nanomaterials present some attractive biological and chemical characteristics with potential uses in the field of biomedical applications. In this context, graphene and its chemical derivatives have been extensively used in many biomedical research areas from drug delivery to bioelectronics and tissue engineering. Graphene-based nanomaterials show excellent optical, mechanical, and biological properties. They can be used as a substrate in the field of tissue engineering due to their conductivity, allowing to study, and educate neural connections, and guide neural growth and differentiation; thus, graphene-based nanomaterials represent an emerging aspect in regenerative medicine. Moreover, there is now an urgent need to develop multifunctional and functionalized nanomaterials able to arrive at neuronal cells through the blood-brain barrier, to manage a specific drug delivery system. In this review, we will focus on the recent applications of graphene-based nanomaterials in vitro and in vivo, also combining graphene with other smart materials to achieve the best benefits in the fields of nervous tissue engineering and neural regenerative medicine. We will then highlight the potential use of these graphene-based materials to construct graphene 3D scaffolds able to stimulate neural growth and regeneration in vivo for clinical applications.

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Section: Biomedical Applicationsmentioning

confidence: 99%

An Update on Graphene-Based Nanomaterials for Neural Growth and Central Nervous System Regeneration

Tupone

Panella

Castelli

et al. 2021

IJMS

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“…Some investigators have reported that GO and its compounds are biocompatible and could guide stem cells to promote proliferation and osteoblast differentiation (Xie, Cao, Rodriguez‐Lozano, Luong‐Van, & Rosa, ). In our previous work, we demonstrated that pristine GO nanoparticles could promote osteogenic differentiation in BMSCs and that 0.1 μg/ml was the most suitable concentration (Farshid et al, ; Wei et al, ). However, the osteogenic effect of GO was limited, and toxicity existed.…”

Section: Introductionmentioning

confidence: 99%

Concentration‐dependent cellular behavior and osteogenic differentiation effect induced in bone marrow mesenchymal stem cells treated with magnetic graphene oxide

Chen

et al. 2019

J Biomedical Materials Res

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The scaffold-free cell sheet plays an important role in stem-cell-based regeneration.Graphene oxide (GO) endows nanoparticles (NPs) with special characteristics and therefore has attracted increasing attention in recent years. However, the existence of toxicity in GO and its derivatives limits their ability to promote osteogenic differentiation. Magnetic graphene oxide (MGO), a novel combination of Fe 3 O 4 and GO with diverse unique properties, has not been studied in bone tissue engineering. In this study, MGO was fabricated, and the previously undiscovered relationshipsincluding cellular behavior and the effects of osteogenic differentiation and related mechanisms of MGO in rat bone-marrow-derived mesenchymal stem cells (BMSCs)were investigated for the first time. Here, we found that MGO was not only biocompatible at low concentrations, but also could significantly accelerate osteogenic differentiation in BMSCs. Both the cellular behavior and bone-formation differentiation in BMSCs treated with MGO showed concentration-dependent characteristics. In addition, the regulation of osteogenic differentiation in BMSCs treated with MGO might be involved with the Wnt/β-catenin and BMP signaling pathways. Furthermore, MGO demonstrated a better ability for osteogenic differentiation in BMSCs than did GO. The current work indicated a significant use for MGO nanocomposite scaffolds in biocompatibility and bone regeneration, which could provide new insight into bone regeneration in the future. K E Y W O R D S bone marrow mesenchymal stem cells, bone tissue regeneration, cellular behavior, magnetic graphene oxide, osteogenic differentiation

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“…The development of new scaffold materials with improved mechanical properties and biodegradability is of great importance in the field of tissue engineering. Until now, both inorganic and organic materials were investigated, and biodegradable synthetic polymers emerged as the most promising candidates for orthopedic applications 1,2 . Poly(propylene fumarate) (PPF) is an unsaturated linear polyester that can be easily crosslinked either thermally or with photoinitiators 3–5 .…”

Section: Introductionmentioning

confidence: 99%

Hema-Functionalized Graphene Oxide: a Versatile Nanofiller for Poly(Propylene Fumarate)-Based Hybrid Materials

Vasile

Pandele

Andronescu

et al. 2019

Sci Rep

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Poly(propylene fumarate) (PPF) is a linear unsaturated polyester which has been widely investigated for tissue engineering due to its good biocompatibility and biodegradability. In order to extend the range of possible applications and enhance its mechanical properties, current approaches consist in the incorporation of various fillers or obtaining blends with other polymers. In the current study we designed a reinforcing agent based on carboxylated graphene oxide (GO-COOH) grafted with 2-hydroxyethyl methacrylate (GO@HEMA) for poly(propylene fumarate)/poly(ethylene glycol) dimethacrylate (PPF/PEGDMA), in order to enhance the nanofiller adhesion and compatibility with the polymer matrix, and in the same time to increase the crosslinking density. The covalent modification of GO-COOH was proved by Fourier-transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), thermogravimetric analysis (TGA) and Raman spectroscopy. The mechanical properties, water uptake capacity, morphology, biodegradability, mineralization and in vitro cytotoxicity of PPF/PEGDMA hybrid materials containing GO@HEMA were investigated. A 14-fold increase of the compressive modulus and a 2-fold improvement in compressive strength were observed after introduction of the nanofiller. Moreover, the decrease in sol fraction and solvent swelling in case of the hybrid materials containing GO@HEMA suggests an increase of the crosslinking density. SEM images illustrate an exfoliated structure at lower nanofiller content and a tendency for agglomeration at higher concentrations. Finally, the synthesized hybrid materials proved non-cytotoxic to murine pre-osteoblast cells and induced the formation of hydroxyapatite crystals under mineralization conditions.

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Two‐dimensional graphene oxide‐reinforced porous biodegradable polymeric nanocomposites for bone tissue engineering

Cited by 23 publications

References 58 publications

An Update on Graphene-Based Nanomaterials for Neural Growth and Central Nervous System Regeneration

An Update on Graphene-Based Nanomaterials for Neural Growth and Central Nervous System Regeneration

Concentration‐dependent cellular behavior and osteogenic differentiation effect induced in bone marrow mesenchymal stem cells treated with magnetic graphene oxide

Hema-Functionalized Graphene Oxide: a Versatile Nanofiller for Poly(Propylene Fumarate)-Based Hybrid Materials

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