Two-dimensional hydrodynamic focusing in a simple microfluidic device

Simonnet, Claire; Groisman, Alex

doi:10.1063/1.2046729

Cited by 121 publications

(102 citation statements)

References 10 publications

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“…19,24 Groisman and other groups fabricated multilayered, threedimensional microfluidic devices to achieve confinement in the vertical direction. 17,21,23,25 However, these techniques have not been widely adopted in practice due to increased complication in fabrication process or the need to increase overall fluid flow rates ͑and thus overall particle velocity͒.…”

Section: A Hydrodynamic Focusingmentioning

confidence: 99%

“…Microfluidic systems in this realm offer the benefit of highly predictable behavior that does not depend on sample size desirable qualities for a microfluidic sample positioning system. Numerous structures [17][18][19][20][21][22][23][24][25] have been designed for hydrodynamic flow focusing under this approximation and will be discussed in Sec. II A.…”

Section: Review On Recent Advancement On Microfluidicsmentioning

confidence: 99%

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Review Article: Recent advancements in optofluidic flow cytometer

Cho¹,

Godin²,

Chen³

et al. 2010

Biomicrofluidics

143

105

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There is an increasing need to develop optofluidic flow cytometers. Optofluidics, where optics and microfluidics work together to create novel functionalities on a small chip, holds great promise for lab-on-a-chip flow cytometry. The development of a low-cost, compact, handheld flow cytometer and microfluorescence-activated cell sorter system could have a significant impact on the field of point-of-care diagnostics, improving health care in, for example, underserved areas of Africa and Asia, that struggle with epidemics such as HIV/AIDS. In this paper, we review recent advancements in microfluidics, on-chip optics, novel detection architectures, and integrated sorting mechanisms.

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Section: A Hydrodynamic Focusingmentioning

confidence: 99%

Section: Review On Recent Advancement On Microfluidicsmentioning

confidence: 99%

Review Article: Recent advancements in optofluidic flow cytometer

Cho¹,

Godin²,

Chen³

et al. 2010

Biomicrofluidics

143

105

View full text Add to dashboard Cite

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“…Clearly, the stripe configuration for producing sheath flow has an advantage in that it requires only one inlet for sheath flow, greatly reducing the number of pumps compared to other microfluidic systems that completely ensheath a core fluid. 26,[28][29][30][31][32] Once the number of stripes is established for a given channel aspect ratio, the sheathing will remain essentially in the center of the channel unless the flow rate is significantly changed. Although the chevron design requires one more pump than the stripe design, it does offer a degree of flexibility.…”

Section: Chevron-based Designmentioning

confidence: 99%

“…One interesting feature of this design is that broad, shallow sample streams can be made, which have been demonstrated to have utility in imaging cell analyzers. 29,38 If a broad-flat ribbon is desired, then the formation of the lobes at either end of the sample stream could probably be reduced or eliminated by altering the shape of the grooves.…”

Section: Chevron-based Designmentioning

confidence: 99%

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Two simple and rugged designs for creating microfluidic sheath flow

et al. 2008

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A simple design capable of 2-dimensional hydrodynamic focusing is proposed and successfully demonstrated. In the past, most microfluidic sheath flow systems have often only confined the sample solution on the sides, leaving the top and bottom of the sample stream in contact with the floor and ceiling of the channel. While relatively simple to build, these designs increase the risk of adsorption of sample components to the top and bottom of the channel. A few designs have been successful in completely sheathing the sample stream, but these typically require multiple sheath inputs and several alignment steps. In the designs presented here, full sheathing is accomplished using as few as one sheath input, which eliminates the need to carefully balance the flow of two or more sheath inlets. The design is easily manufactured using current microfabrication techniques. Furthermore, the sample and sheath fluid can be subsequently separated for recapture of the sample fluid or re-use of the sheath fluid. Designs were demonstrated in poly(dimethylsiloxane) (PDMS) using soft lithography and poly(methyl methacrylate) (PMMA) using micromilling and laser ablation.

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Fluidics

Suthanthiraraj

Graves

2013

CP Cytometry

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The use of fluidics is implicit in a technology named “flow cytometry”, which flows a cell or particle through a sensing volume to obtain serial analysis of particles on a one by one basis. This flow of particles enables flow cytometry to collect information on multiple particle populations, giving it a distinct advantage over bulk analysis approaches. Moreover, flow cytometers can analyze thousands of particles per second in a single flowing stream. Additionally, use of volumetric sample delivery makes it possible for flow cytometers to accurately count cells and particles. Furthermore, the analysis results can be coupled with a fluidic diversion mechanism to sort and collect particles based on desired properties. Finally, when high throughput sampling technologies are employed to rapidly change the input of the sample stream, a flow cytometer can become an integral tool for high throughput screening. The above properties have made flow cytometry useful in a wide range of biomedical applications. In this unit we will present an overview of fluidic systems that make flow cytometry possible. This will introduce historical approaches, explanations of the commonly implemented current fluidics, and brief discussions of potential future fluidics where appropriate.

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Two-dimensional hydrodynamic focusing in a simple microfluidic device

Abstract: Articles you may be interested inTwo-and three-dimensional modeling and optimization applied to the design of a fast hydrodynamic focusing microfluidic mixer for protein folding Phys. Fluids 25, 032001 (2013);

Cited by 121 publications

References 10 publications

Review Article: Recent advancements in optofluidic flow cytometer

Review Article: Recent advancements in optofluidic flow cytometer

Two simple and rugged designs for creating microfluidic sheath flow

Fluidics

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